Antiretrovirals: Nucleoside/ Nucleotide Reverse Transcriptase inhibitors (NRTI/NtRTI) Flashcards

1
Q

which NRTIs have hepatitis B activity?

A

emtricitabine, lamivudine, tenofovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the side effects of abacavir?

A

risk of hypersensitivity reactions (fever, rash, nausea, vomiting, abdo pain) in HLA-B*5701 positive patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

which NRTIs have minimal toxicity

A

emtricitabine, lamivudine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are the side effects of stavudine?

A
  • lipodystrophy
  • peripheral neuropathy
  • lactic acidosis
  • pancreatitis
  • hyperlipidaemia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are the side effects of tenofovir?

A
  • renal impairment
  • fanconi syndrome
  • osteomalacia
  • decrease in bone mineral density
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what are the side effects of zidovudine?

A
  • macrocytic anaemia
  • lipodystrophy
  • hyperlipidaemia
  • GI disturbances- nausea & vomiting
  • lactic acidosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly