Antiretrovirals: Nucleoside/ Nucleotide Reverse Transcriptase inhibitors (NRTI/NtRTI) Flashcards
1
Q
which NRTIs have hepatitis B activity?
A
emtricitabine, lamivudine, tenofovir
2
Q
what are the side effects of abacavir?
A
risk of hypersensitivity reactions (fever, rash, nausea, vomiting, abdo pain) in HLA-B*5701 positive patients
3
Q
which NRTIs have minimal toxicity
A
emtricitabine, lamivudine
4
Q
what are the side effects of stavudine?
A
- lipodystrophy
- peripheral neuropathy
- lactic acidosis
- pancreatitis
- hyperlipidaemia
5
Q
what are the side effects of tenofovir?
A
- renal impairment
- fanconi syndrome
- osteomalacia
- decrease in bone mineral density
6
Q
what are the side effects of zidovudine?
A
- macrocytic anaemia
- lipodystrophy
- hyperlipidaemia
- GI disturbances- nausea & vomiting
- lactic acidosis