Antiretrovirals: Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI) Flashcards

1
Q

What is the dosing of Efavirenz?

A

once daily dose on empty stomach

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2
Q

what is the side effects of efavirenz?

A
  • cns symptoms: dizziness, insomnia, abnormal dreams, impaired concentration
  • rash
  • transaminitis
  • hyperlipidaemia
  • pregnancy category D
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3
Q

What is the dosing of nevirapine?

A

twice daily dose

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4
Q

What are the side effects of nevirapine?

A
  • rash including SJS
  • transaminitis
  • avoid initiation in ART naive woman with CD4 > 250 cells/ mm3 and ART naive man with CD4 > 400 cells/ mm3
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