Antiretrovirals: Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI) Flashcards
1
Q
What is the dosing of Efavirenz?
A
once daily dose on empty stomach
2
Q
what is the side effects of efavirenz?
A
- cns symptoms: dizziness, insomnia, abnormal dreams, impaired concentration
- rash
- transaminitis
- hyperlipidaemia
- pregnancy category D
3
Q
What is the dosing of nevirapine?
A
twice daily dose
4
Q
What are the side effects of nevirapine?
A
- rash including SJS
- transaminitis
- avoid initiation in ART naive woman with CD4 > 250 cells/ mm3 and ART naive man with CD4 > 400 cells/ mm3