Antibiotics: Macrolides

Question 1

What are the examples of macrolides?

Answer 1

Erythromycin (PO), clarithromycin (PO), azithromycin (IV/ PO)

Question 2

what do macrolides cover?

Answer 2

• GPC: Streptococcus spp.

- GNR: Haemophilus spp.spp., Moraxella catarrhalis, Legionella spp.spp., Chlamydophila spp.spp., Mycoplasma spp.

Question 3

What are the indications of macrolides?

Answer 3

• Upper respiratory tract infection, pharyngitis
• Atypical pneumonia
• Combination treatment for H. pylori eradication
• STI - chlamydia; non gonococcal urethritis (NGU)

Question 4

What are the adverse effects of macrolides?

Answer 4

QT prolongation, GI side effects used to stimulate GI motility