Antifungals: Azoles Flashcards
1
Q
What is the mechanism of action of azoles?
A
Inhibition of P450 dependent enzyme lanosterol 14-alpha- demethylase which converts lanosterol to ergosterol?
2
Q
what are the side effects of fluconazoles?
A
- hepatotoxicity
- hypokalaemia
3
Q
what are the side effects of itraconazoles?
A
- hepatotoxicity
- hypokalaemia
- hypertension
- peripheral oedema
- caution in heart failure
4
Q
what are the side effects of voriconazoles?
A
- hepatoxicity
- transient visual disturbance
- neurologic toxicity
- photosensitivity
5
Q
Out of the 3 azoles (fluconazole, itraconazole, voriconazole), which of them needs renal adjustment?
A
voriconazole
6
Q
Which of the azoles have activity against candida albicans?
A
fluconazole, itraconazole, voriconazole
7
Q
Which of the azoles have activity against cryptococcus?
A
fluconazole, voriconazole
8
Q
Which of the azoles have activity against histoplasma?
A
itraconazole, voriconazole
9
Q
Which of the azoles have activity against aspergillus?
A
itraconazole, voriconazole
