Antimalarials Flashcards
1
Q
What is the treatment for plasmodium falciparum (complicated)?
A
- IV artesunate + doxycycline/ clindamycin
- IV quinine + doxycycline/ clindamycin
2
Q
What is the treatment for plasmodium falciparum (uncomplicated)?
A
- PO atovaquone- proguanil (Malarone)
- PO artesunate + PO mefloquine
- PO quinine sulfate + doxycycline/ clindamycine
3
Q
What is the treatment for plasmodium vivax/ ovale?
A
PO chloriquine + PO primaquine
4
Q
What is the treatment for plasmodium malariae/ knowlesi?
A
PO chloroquine
5
Q
What are the side effects of quinine?
A
- cinchonism (tinnitus, vomiting, diarrhoea, headache)
- hypoglycaemia
- hypotension
- QT prolongation (cardiac moitoring)
6
Q
What are the side effects of mefloquine?
A
- vomiting and dizziness
- c/i in patients for preexisting neurologic and psychiatric illness
- QT prolongation
7
Q
What are the side effects of chloroquine?
A
- resistance now common for p. falciparum
- dizziness, headache, gi side effects
8
Q
what are the side effects of primaquine?
A
- active against hypnozoite stage of p. vivax
- haemolysis in G6pD defeciency
9
Q
what are the side effects of atovaquone- proguanil?
A
GI side effects, hepatitis
