Antibiotics: Aminoglycosides Flashcards

1
Q

What are examples of aminoglycosides?

A

Amikacin (IV), gentamicin (IV), tobramycin (IV), streptomycin (IV/ IM)

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2
Q

what do aminoglycosides cover?

A

GNB: Enterobacteriaceae, P. aeruginosa

Mycobacteria

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3
Q

what are the indications for use of aminoglycosides?

A
UTI, intra abdominal infections, bacteraemia
Mycobacterium tuberculosis (streptomycin)
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4
Q

what are the adverse effects of aminoglycosides?

A

Nephrotoxicity (5 - 25%) - reversible

Ototoxicity (3- 14%) - vertigo, ataxia (vestibular) or tinnitus, hearing loss (cochlear)

Neuromuscular blockade

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