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Infectious Disease > Antifungals: Polyenes > Flashcards

Antifungals: Polyenes Flashcards

1
Q

what is the mechanism of polyenes?

A

Bind to ergosterols in fungal cell membrane causing formation of pores, leakage of cellular components and cell death

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2
Q

what are examples of polyenes?

A

Amphotericin (IV)

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3
Q

what is the activity of polyenes?

A

Candida spp, Aspergillus Spp, Endemic mycoses

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4
Q

what are the activities of polyenes?

A
  • Infusion related reactions –chills, fever, headache, nausea, vomiting
  • Nephrotoxicity
  • Electrolyte disturbance -↓K+, ↓Mg2+
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Infectious Disease (55 decks)

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