Antiretrovirals: Protease Inhibitors (PI) Flashcards

1
Q

What are some examples of Protease Inhibitors?

A

Atazanavir, Darunavir, Lopinavir, Ritonavir

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2
Q

What are the side effects of Atazanavir?

A
  • hyperlipidaemia, hepatitis, fat maldistribution, hyperglycaemia
  • indirect hyperbilirubinaemia
  • PR interval prolongation
  • Kidney stones
  • Reduced absorption with concomitant H2 antagonists and proton pump inhibitors
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3
Q

What are the side effects of Darunavir?

A
  • hyperlipidaemia, hepatitis, fat maldistribution, hyperglycaemia
  • skin rash
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4
Q

What are the side effects of Lopinavir?

A
  • hyperlipidaemia, hepatitis, fat maldistribution, hyperglycaemia
  • GI symptoms- diarrhoea
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5
Q

What are the side effects of Ritonavir?

A
  • hyperlipidaemia, hepatitis, fat maldistribution, hyperglycaemia
  • GI symptoms: diarrhoea, nausea, vomiting
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