Antiretrovirals: Protease Inhibitors (PI) Flashcards
1
Q
What are some examples of Protease Inhibitors?
A
Atazanavir, Darunavir, Lopinavir, Ritonavir
2
Q
What are the side effects of Atazanavir?
A
- hyperlipidaemia, hepatitis, fat maldistribution, hyperglycaemia
- indirect hyperbilirubinaemia
- PR interval prolongation
- Kidney stones
- Reduced absorption with concomitant H2 antagonists and proton pump inhibitors
3
Q
What are the side effects of Darunavir?
A
- hyperlipidaemia, hepatitis, fat maldistribution, hyperglycaemia
- skin rash
4
Q
What are the side effects of Lopinavir?
A
- hyperlipidaemia, hepatitis, fat maldistribution, hyperglycaemia
- GI symptoms- diarrhoea
5
Q
What are the side effects of Ritonavir?
A
- hyperlipidaemia, hepatitis, fat maldistribution, hyperglycaemia
- GI symptoms: diarrhoea, nausea, vomiting