Antimicrobial therapy (part 3)

Question 1

Are Amino glycosides bacterial cidial or static?

Answer 1

cidil

Question 2

do Aminoglycosides fight gram + or gram -?

Answer 2

gram -

Question 3

How do Aminoglycosides kill bacteria?

Answer 3

they bind irreversibly to 30s subunit of bacterial ribosomes

Question 4

therapeutic window for Aminoglycosides?

Answer 4

narrow need to monitor

Question 5

which adverse effects are associated with Aminoglycosides?

Answer 5

nephrotoxicity and ototoxicity

Question 6

which infections do we use Aminoglycosides topically?

Answer 6

irrigation of infected wounds

Question 7

which infections do we use Aminoglycosides parenterally?

Answer 7

complicated UTIs, skin bone tissue, peritonitis

Question 8

Neomycin, streptomycin kanamycin are Aminoglycosides that should not be used when?

Answer 8

in pregnancy

Question 9

alert MD for which symptoms when taking Aminoglycosides

Answer 9

visual, hearing or urinary problems develop

Question 10

Are sulfonamides bacterial cidial or static?

Answer 10

static

Question 11

which type of bacteria are not affected by sulfonamides?

Answer 11

bacteria that do not require folic acid or bacteria that can absorb it from GI tract

Question 12

How do sulfonamides kill bacteria?

Answer 12

prevents bacteria from synthesizing folic acid

Question 13

do sulfonamides fight against gram + or gram -?

Answer 13

both

Question 14

what diseases are sulfonamides used for?

Answer 14

UTI, otitis media, sinusitis

Question 15

what category are sulfonamides? and why is it important not to use?

Answer 15

C/D, do not use at term d/t folic acid inhibition

Question 16

early signs of severe reactions to sulfonamides? and what should you do if you see them?

Answer 16

rash, sore throat, fever, arthralgia, cough, SOB, DISCONTINUE