Antimicrobial therapy (part 2)

Question 1

Lyme disease, COPD exacerbations, anthrax, sinitis, Ricketsial infections, chlamydia are all diseases that can be treated with which antibiotics?

Answer 1

Tetracyclines

Question 2

Tetracycline medication administration education (take with/without food, do not take with which other things?)

Answer 2

take on an empty stomach 1 hr before or 2 hrs after meals, do NOT take with milk, antacids, iron, mg

Question 3

Can you give tetracycline to kids?

Answer 3

NO, causes permanate damage to teeth and bones

Question 4

Can you give tetracycline to pregnant people or breast feeders?

Answer 4

NO category D

Question 5

Are tetracyclines bacterial static or bacterial cidil?

Answer 5

Static

Question 6

How do tetracyclines work against bacteria?

Answer 6

prohibits protein synthesis by binding to 30s ribosome

Question 7

Tetracyclines adverse effects

Answer 7

photosensitivity, increased BUN levels

Question 8

first line for otits media?

Answer 8

Amoxicillin

Question 9

how do penicillins work against bacteria?

Answer 9

disrupts cell wall growth, activates autolytic enzymes that cause bacterial lysis

Question 10

Penicillian medication administration education (take with/without food)

Answer 10

take on empty stomach with full glass of water

Question 11

Are Macrolides bacterial static or bacterial cidil?

Answer 11

both

Question 12

first line drug for uncomplicated infections?

Answer 12

Macrolides

Question 13

How do Macrolides work against bacteria?

Answer 13

inhibits protein synthesis

Question 14

Are Cephalosporins bacterial static or bacterial cidil?

Answer 14

cidial

Question 15

How doo cephalosporins work against bacteria?

Answer 15

interferes with peptidoglycan in cell wall

Question 16

Cephalosporins medication administration education (take with/without food)

Answer 16

take with food or milk to prevent GI upset

Question 17

Are cephalosporins gram + or gram -?

Answer 17

1st and 2nd generation more gram +, 3rd both, 4th gram-

Question 18

Are Fluoroquinolones bacterial static or bacterial cidil?

Answer 18

Cidial

Question 19

how do fluoroquinolone work against bacteria?

Answer 19

interferes with enzymes needed for bacteria synthesis

Question 20

Geriatric risk for taking fluoroquinolone

Answer 20

tendon rupture

Question 21

Pediatric and pregnancy rules forfluoroquinolone

Answer 21

only give if there is nothing else, lactation: NO

Question 22

what should you monitor with fluoroquinolone

Answer 22

renal hepatic function, coumadin levels

Question 23

fluoroquinolone medication administration education (take with/without food, do not take with which other things?)

Answer 23

can take with or without food, do not take with milk, Mg, Ca, Iron

Question 24

photosensitivity occurs with which drugs?

Answer 24

fluoroquinolone, tetracyclines

Question 25

``` Which class type are: Beta-lactams Penicillins Cephalosporins Carbapenems Monobactams Vancomycin Cycloserine ```

Answer 25

cell wall synthesis inhibitors

Question 26

``` Mechanism of action for: Beta-lactams Penicillins Cephalosporins Carbapenems Monobactams ```

Answer 26

-Bind to specific receptors membrane -Inhibit peptidoglycan cross-linking -Activate autolytic enzymes within the bacteria

Question 27

``` Bacterialstatic or cidial? Beta-lactams Penicillins Cephalosporins Carbapenems Monobactams ```

Answer 27

cidial

Question 28

mechanism of action for: Vancomycin Cycloserine

Answer 28

Inhibits the second step of cell wall synthesis

Question 29

Bacterialstatic or cidial?

Answer 29

cidial

Question 30

What class are Clavulanic acid Sulbactam Tazobactam

Answer 30

Beta-lactamase inhibitors

Question 31

mechanism of action for Beta-lactamase inhibitors? (Clavulanic acid, Sulbactam, Tazobactam)

Answer 31

Inhibit beta-lactamases and prevent them from destroying the antibiotics Have little antibacterial activity if given alone

Question 32

``` what class are: Aminoglycosides Tetracyclines Chloramphenicol Macrolides ```

Answer 32

Protein Synthesis Inhibitors

Question 33

which drugs have a mechanism of action that Inhibits protein synthesis by binding irreversibly to the 30S ribosomal subunit

Answer 33

Aminoglycosides, Tetracyclines

Question 34

are Aminoglycosides static or cidial?

Answer 34

cidial

Question 35

which drug has the mechanism of action that Inhibits the enzyme peptidyl transferase and the formation of peptide bonds by binding the 50S ribosomal subunit?

Answer 35

Chloramphenicol

Question 36

Is Chloramphenicol static or cidial?

Answer 36

static

Question 37

which drugs have the mechanism of action: Inhibit protein synthesis by stimulating dissociation of RNA from the ribosome

Answer 37

Macrolides

Question 38

Are Macrolides static or cidial?

Answer 38

both

Question 39

which drug has a mechanism of action: Inhibit replication by binding DNA gyrase

Answer 39

Fluoroquinolones

Question 40

are Fluoroquinolones cidial or static?

Answer 40

cidial

Question 41

which drug has the mechanism of action:Inhibits transcription by binding DNA-dependent RNA polymerase

Answer 41

Rifampin

Question 42

Is Rifampin cidial or static?

Answer 42

cidial

Question 43

which drugs are in the Nucleic | Acid Synthesis & Replication Inhibitors class?

Answer 43

Fluoroquinolones,Rifampin

Question 44

which drugs are Metabolic Inhibitors

Answer 44

Sulfonamides, Trimethoprim

Question 45

which drug has the mechanism of action: Competitively inhibits dihydrofolate reductase

Answer 45

Trimethoprim

Question 46

which drug has the mechanism of action:Competitively inhibit PABA (para-amino benzoic acid) and disrupt folate synthesis pathway

Answer 46

Sulfonamides

Question 47

Sulfonamides are static or cidial?

Answer 47

static

Question 48

Trimethoprim are static or cidial?

Answer 48

static