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Pharm > Antimicrobial therapy (part 2) > Flashcards

Antimicrobial therapy (part 2) Flashcards

1
Q

Lyme disease, COPD exacerbations, anthrax, sinitis, Ricketsial infections, chlamydia are all diseases that can be treated with which antibiotics?

A

Tetracyclines

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2
Q

Tetracycline medication administration education (take with/without food, do not take with which other things?)

A

take on an empty stomach 1 hr before or 2 hrs after meals, do NOT take with milk, antacids, iron, mg

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3
Q

Can you give tetracycline to kids?

A

NO, causes permanate damage to teeth and bones

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4
Q

Can you give tetracycline to pregnant people or breast feeders?

A

NO category D

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5
Q

Are tetracyclines bacterial static or bacterial cidil?

A

Static

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6
Q

How do tetracyclines work against bacteria?

A

prohibits protein synthesis by binding to 30s ribosome

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7
Q

Tetracyclines adverse effects

A

photosensitivity, increased BUN levels

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8
Q

first line for otits media?

A

Amoxicillin

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9
Q

how do penicillins work against bacteria?

A

disrupts cell wall growth, activates autolytic enzymes that cause bacterial lysis

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10
Q

Penicillian medication administration education (take with/without food)

A

take on empty stomach with full glass of water

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11
Q

Are Macrolides bacterial static or bacterial cidil?

A

both

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12
Q

first line drug for uncomplicated infections?

A

Macrolides

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13
Q

How do Macrolides work against bacteria?

A

inhibits protein synthesis

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14
Q

Are Cephalosporins bacterial static or bacterial cidil?

A

cidial

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15
Q

How doo cephalosporins work against bacteria?

A

interferes with peptidoglycan in cell wall

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16
Q

Cephalosporins medication administration education (take with/without food)

A

take with food or milk to prevent GI upset

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17
Q

Are cephalosporins gram + or gram -?

A

1st and 2nd generation more gram +, 3rd both, 4th gram-

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18
Q

Are Fluoroquinolones bacterial static or bacterial cidil?

A

Cidial

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19
Q

how do fluoroquinolone work against bacteria?

A

interferes with enzymes needed for bacteria synthesis

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20
Q

Geriatric risk for taking fluoroquinolone

A

tendon rupture

21
Q

Pediatric and pregnancy rules forfluoroquinolone

A

only give if there is nothing else, lactation: NO

22
Q

what should you monitor with fluoroquinolone

A

renal hepatic function, coumadin levels

23
Q

fluoroquinolone medication administration education (take with/without food, do not take with which other things?)

A

can take with or without food, do not take with milk, Mg, Ca, Iron

24
Q

photosensitivity occurs with which drugs?

A

fluoroquinolone, tetracyclines

25
Q 
Which class type are: 
Beta-lactams
Penicillins
Cephalosporins
Carbapenems
Monobactams
Vancomycin 
Cycloserine
A

cell wall synthesis inhibitors

26
Q 
Mechanism of action for:
Beta-lactams
Penicillins
Cephalosporins
Carbapenems
Monobactams
A

-Bind to specific receptors
membrane
-Inhibit peptidoglycan cross-linking
-Activate autolytic enzymes within the bacteria

27
Q 
Bacterialstatic or cidial?
Beta-lactams
Penicillins
Cephalosporins
Carbapenems
Monobactams
A

cidial

28
Q

mechanism of action for:
Vancomycin
Cycloserine

A

Inhibits the second step of cell wall synthesis

29
Q

Bacterialstatic or cidial?

A

cidial

30
Q

What class are
Clavulanic acid
Sulbactam
Tazobactam

A

Beta-lactamase inhibitors

31
Q

mechanism of action for Beta-lactamase inhibitors? (Clavulanic acid, Sulbactam,
Tazobactam)

A

Inhibit beta-lactamases and prevent them from destroying the antibiotics
Have little antibacterial activity if given alone

32
Q 
what class are:
Aminoglycosides 
Tetracyclines
Chloramphenicol 
Macrolides
A

Protein Synthesis Inhibitors

33
Q

which drugs have a mechanism of action that Inhibits protein synthesis by binding irreversibly to the 30S ribosomal subunit

A

Aminoglycosides, Tetracyclines

34
Q

are Aminoglycosides static or cidial?

A

cidial

35
Q

which drug has the mechanism of action that Inhibits the enzyme peptidyl transferase and the formation of peptide bonds by binding the 50S ribosomal subunit?

A

Chloramphenicol

36
Q

Is Chloramphenicol static or cidial?

A

static

37
Q

which drugs have the mechanism of action: Inhibit protein synthesis by stimulating dissociation of RNA from the ribosome

A

Macrolides

38
Q

Are Macrolides static or cidial?

A

both

39
Q

which drug has a mechanism of action: Inhibit replication by binding DNA gyrase

A

Fluoroquinolones

40
Q

are Fluoroquinolones cidial or static?

A

cidial

41
Q

which drug has the mechanism of action:Inhibits transcription by binding DNA-dependent RNA polymerase

A

Rifampin

42
Q

Is Rifampin cidial or static?

A

cidial

43
Q

which drugs are in the Nucleic

Acid Synthesis & Replication Inhibitors class?

A

Fluoroquinolones,Rifampin

44
Q

which drugs are Metabolic Inhibitors

A

Sulfonamides, Trimethoprim

45
Q

which drug has the mechanism of action: Competitively inhibits dihydrofolate reductase

A

Trimethoprim

46
Q

which drug has the mechanism of action:Competitively inhibit PABA (para-amino benzoic acid) and disrupt folate synthesis pathway

A

Sulfonamides

47
Q

Sulfonamides are static or cidial?

A

static

48
Q

Trimethoprim are static or cidial?

A

static

Pharm (33 decks)

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