antimicrobial chemotherapy - anti fungal drugs

Question 1

What can fungus be subdivided into

Answer 1

Yeats and filamentous fungi (moulds)

Question 2

What is the combined form of fungus called

Answer 2

dimorphic fungi

Question 3

What are the different classes of anti fungal drugs

Answer 3

Polyenes
Azoles
Allyamines
Echinocandins

Question 4

How do polyenes increase the permeability of the cell wall

Answer 4

Bind to ergosterol in fungi cell wall

Question 5

What is the reason for polyenes toxicity

Answer 5

also bind to other sterols (cholesterol) in mammalian cells

Question 6

What are two examples of polyenes anti fungal drugs

Answer 6

amphotericin B

Nystatin

Question 7

Is amphotericin toxic?

Answer 7

yes

Question 8

What polyenes anti fungal drug can be available for IV use

Answer 8

amphotericin B

Question 9

How is nystatin available

Answer 9

topic use (creams, oral, pessaries)

Question 10

How do azoles work as an anti fungal

Answer 10

inhibit ergosterol synthesis

Question 11

How are azoles subdivided

Answer 11

Imidazoles

triazoles

Question 12

Name two imidazoles

Answer 12

miconazole

ketoconazole

Question 13

Give three examples of triazoles

Answer 13

flucanozole
itraconazole
voriconazole

Question 14

How is flucaozole given and what is it active against

Answer 14

used for oral and parenteral treatment of yeast infections

Question 15

What is itraconazole active against

Answer 15

Yeast and filamentous fungi

Question 16

What can treat aspergillosis

Answer 16

voriconazole and itraconazole

Question 17

What is building a resistance to fluconazole

Answer 17

resistance among some candida species

Question 18

How do allylamines work as anti fungals

Answer 18

suppress ergosterol synthesis

Question 19

what is an example of an allylamine anti fungal

Answer 19

terbinafine

Question 20

What is terabinafine primarily active against and its clinical use

Answer 20

dermatophytes

dermatophyte infections of the skin and nails e.g. athletes foot

Question 21

How does echinocandins work as an anti fungal

Answer 21

inhibit the synthesis of glucan polysaccharide

Question 22

What are the three echinocandins

Answer 22

caspofungin
mycafungin
andiulafungin

Question 23

What are ecinocandins used for

Answer 23

serious aspergillus and candida infections