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FARMA 2º CUATRI > Antiagregantes plaquetarios > Flashcards

Antiagregantes plaquetarios Flashcards

1
Q

cuales son los Inhibidores de la ciclooxigenasa I?

A

Aspirina, AINEs, Sulfiniprazona y Trifusal

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2
Q

cuales son los Inhibidores de la fosfodiesterasa?

A

Dipiridamol

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3
Q

cuales son las Tienopiridinas?

A

Ticlopidina, Clopidogrel, Prasugrel y Ticagrelor

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4
Q

Absorción de la aspirina?

A

oral

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5
Q

La aspirina bloquea a la COX1 de forma reversible o irreversible?

A

Irreversible

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6
Q

Atraviesa barreras la aspirina?

A

Si, BHE y BPL

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7
Q

Excreción de la aspirina?

A

renal

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8
Q

Metabolismo de AINEs?

A

Hepático por cit p450 y 1º paso hepático

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9
Q

AINEs bloquea la COX1 de forma reversible o irreversible?

A

Reversible

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10
Q

Efectos adversos de AINEs?

A

Gastrointestinales, renales, síndrome de Reye, hepatotoxicidad…

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11
Q

Sulfinpirazona y trifusal bloquean la COX1 de forma reversible o irreversible?

A

Reversible, son menos eficaces

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12
Q

Qué efecto adverso tienen sulfinpirazona y trifusal?

A

Molestias gástricas

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13
Q

Que funcion tiene dipiridamol?

A

Inhibe fosfodiesterasa y bloquea receptor para adenosina, aumenta AMPc plaquetario inhibiendo la agregación plaquetaria

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14
Q

Absorción de dipiridamol?

A

Oral o intravenosa

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15
Q

De qué depende la absorción de dipiridamol?

A

De pH y tto concomitante con supresores de ácido gástrico como IBPs

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16
Q

Distribución de dipiridamol?

A

amplia

17
Q

Atraviesa barreras el dipiridamol?

A

La placentaria

18
Q

Excreción del dipiridamol?

A

Leche materna, heces y una parte orina

19
Q

Metabolismo del dipiridamol?

A

Glucuronación hepática

20
Q

Efectos adversos del dipiridamol?

A

Cefaleas, enrojecimiento cutáneo, palpitaciones y diarrea

21
Q

Las tienopiridinas que función tienen?

A

Bloquean de forma irreversible al receptor plaquetario del adenosin difosfato

22
Q

De las tienopiridinas, cual bloquea de forma reversible el receptor del adenosin fosfato?

A

Tricagrelol

23
Q

Vía de administración de las tienopiridinas?

A

Oral, 1º paso hepático

24
Q

Metabolismo de las tienopiridinas?

A

Hepático

25
Q

Eliminación de las tienopiridinas?

A

Biliar, leche

26
Q

Efectos adversos de las tienopiridinas?

A

Tolerancia, GI, alergias, hemorragia

27
Q

Tolerancia, GI, alergias, hemorragia

A

Neutropenia reversible

FARMA 2º CUATRI (23 decks)

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