Antenatal Screening Flashcards

1
Q

how do you calculate sensitivity?

A

true positive/(all positive + false negative)

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2
Q

how do you calculate specificity?

A

true negative/(all negative + false positive)

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3
Q

when is the booking visit completed?

A

between 8-12 weeks gestation

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4
Q

what four things are done at the booking visit?

A

history
examination
blood tests
urinalysis

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5
Q

what three examinations are done during the booking visit?

A

height
weight
blood pressure

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6
Q

what bloods are done at the booking visit?

A
haemoglobin 
rhesus status 
syphilis 
HIV
Hep B+C
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7
Q

when is the first ultrasound done?

A

8-12 weeks gestation

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8
Q

what does the first ultrasound scan look for?

A

viability
how many
estimate gestational age
structural anomalies

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9
Q

when is the most accurate time to establish the EDD?

A

8-12 weeks

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10
Q

what is EDD?

A

estimated date of delivery

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11
Q

what rule can be used to calculate EDD?

A

naegele’s rule

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12
Q

what is naegele’s rule?

A

add on nine months and seven days/280 days to the date of onset of a woman’s LMP = EDD

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13
Q

when is the foetal anomaly scan done?

A

20 weeks

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14
Q

what should be investigated in a history at the foetal anomaly scan?

A

physical/mental health of mother

foetal movements

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15
Q

what examinations should be done at the foetal anomaly scan?

A
BP
urinalysis 
SFH
lie + presentation 
foetal heart auscultation
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16
Q

what is SFH?

A

symphysis fundal height

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17
Q

what is placenta praevia?

A

when the placenta is low lying in the uterus and covers the cervix

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18
Q

if placenta praevia is seen at 20 weeks, when is another scan done?

A

32 weeks

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19
Q

what trisomy’s can be screened for?

A

21
18
13

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20
Q

what is trisomy 21?

A

downs syndrome

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21
Q

what is trisomy 18?

A

Edwards syndrome

22
Q

what is trisomy 13?

A

patau’s syndrome

23
Q

what secondary screening test is offered if there is a high risk result for a trisomy?

24
Q

how is trisomy screening performed in the first trimester?

A

measure nuchal thickness (NT)

combine this with HCG and PAPP-A for a full assessment

25
when is trisomy screening done in the first trimester?
11-13+6 weeks
26
what is a normal result for NT in the first trimester?
<3.5mm if the CRL is 45-85mm
27
what is CRL?
crown rump length
28
what trisomy can be screened for in the second trimester?
trisomy 21
29
why would second trimester screening for T21 be done?
first missed | first unsuccessful
30
when is second trimester screening for T21 done?
15-20 weeks
31
what is involved in second trimester screening for T21?
blood sample for biochemical markers | look at maternal age
32
what biochemical markers are checked as part of trisomy screening in trimester two?
AFP hCG unconjugated oestradiol inhibin A
33
when is further investigation for trisomy 21 done?
>1:150 risk of the condition
34
how can further investigation of trisomy's be completed?
NIPT | CVS/amniocentesis
35
what does NIPT stand for?
non invasive prenatal testing
36
what is another name for NIPT?
cell free foetal DNA testing (cffDNA)
37
what does NIPT detect?
foetal DNA fragments in the maternal blood
38
when is cffDNA detectable?
from around 10 weeks increases as pregnancy continues
39
what is done if NIPT is positive for trisomy?
diagnostic testing NIPT IS JUST ANOTHER SCREENING TEST
40
what are the two diagnostic tests for trisomy's?
amniocentesis | chorionic villus sampling (CVS)
41
what risk is associated with amniocentesis and CVS?
miscarriage
42
when is amniocentesis performed?
after 15 weeks
43
when is CVS performed?
after 12 weeks
44
when is maternal anaemia screened for?
booking | 28 weeks
45
name five risk factors for gestational diabetes
``` BMI >30 previous macrosomia - >4.5kg previous gestational diabetes family history of diabetes minority ethnic origin with high prevalence of diabetes ```
46
when should SFH be measured and why?
all antenatal appointments from 24 weeks improves prediction of an SGA neonate
47
who should be referred for ultrasound measurement of foetal height?
one SFH < 10th gentile serial measurements showing slow/static growthh
48
when can measuring SFH be difficult and what is done for these patients?
BMI>30, large fibroids, hydramnios etc. ultrasound assessment of foetal size
49
what should women at high risk for pre-eclampsia take?
150mg aspirin daily from 12-36 weeks
50
what makes you high risk for pre-eclampsia?
``` hypertensive disease during a previous pregnancy CKD autoimmune disease diabetes chronic hypertension ```
51
what should women at moderate risk for pre-eclampsia take?
more than one moderate risk factor = 150mg aspirin daily from 12 weeks til birth
52
what makes you moderate risk for pre-eclampsia?
``` first pregnancy >40 pregnancy interval >10 years BMI >35 family history of pre-eclampsia multiple pregnancy ```