Anatomy - Week 14 PP Flashcards

1
Q

Glossitis

A
  • General term used to describe inflammation and
    changes in the topography of the tongue
  • There is atrophy of the papilla to creating a
    smooth erythematous tongue
  • Causes: * Allergic reactions
  • Irritations from foods
  • Nutritional deficiencies
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2
Q

Black Hairy Tongue

A
  • The filiform papillae are so greatly elongated that
    they resemble hairs
  • These elongated papillae become stained by food
    tobacco and chromogenic bacteria, hence the
    name
  • May be caused by an imbalance of oral flora after the administration of antibiotics or the use of
    mouthrinses
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3
Q

Fissured Tongue

A
  • Fissured tongue is a variant of normal; its cause is unknown
  • Theories about its cause include vitamin deficiency and chronic trauma over a long period
  • The dorsal surface (top) of the tongue is marked
    by having deep fissures or grooves, which become
    irritated if food debris collects in them
  • Patient with a fissured tongue is advised to brush
    the tongue gently with a soft toothbrush to keep
    the fissures clean of debris and irritants
  • variation of normal, not to be worried about HOWEVER extra care is required..
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4
Q

Bifid Tongue

A
  • Rare
    -Partial fusion of the tounge during development
  • no treatment required
  • split of tongue into 2
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5
Q

Ankyloglossia

A
  • Tongue tie
  • The lingual frenum is attached near the tip of the tongue
  • The short lingual frenum can also attached the tip
    of the tongue to the floor of the mouth
  • Limits movement of the tongue
    ◦ Speech disruption
  • Treatment ◦ Frenectomy (surgical removal of part of the lingual frenum)
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6
Q

Clinical Considerations

A

The Oral Mucosa is a good indicator of health or
disease
* Many diseases or conditions manifest in some way on oral tissue
* The dental team plays an important role in early
detection of these diseases

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7
Q

Pernicious Anemia

A
  • A condition in which the body does not absorb vitamin B12
  • People with this condition show signs of anemia, weakness, pallor, and fatigue on exertion
  • Other signs include nausea, diarrhea, abdominal pain, and loss of appetite
  • Oral manifestations of pernicious anemia include angular cheilitis (ulceration and redness at the corners of the lips), mucosal ulceration, loss of papillae on the tongue, and a painful burning sensation of the tongue
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8
Q

HIV and AIDS

A

Oral lesions are prominent features of acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection
* Oral lesions develop because of the breakdown of the immune system that occurs when the T-helper cells become depleted as a result of the disease

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9
Q

Acquired Immunodeficiency Syndrome

A
  • Because the patient’s immune system is severely damaged, death is usually caused by an
    opportunistic infection
  • Opportunistic infection: One that normally would be controlled by the immune system but cannot be controlled because the immune system is not
    functioning properly
  • Some of the lesions that look like HIV- and AIDS related infection may also be caused by other
    disorders
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10
Q

HIV Gingivitis

A
  • There is often a bright red line along the border of the free gingival margin
  • Also known as atypical gingivitis(ATYP) * In some cases, there may be progression of the
    bright red line from the free gingival margin over the attached gingival and alveolar mucosa
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11
Q

HIV Periodontitis

A
  • Resembles acute necrotizing ulcerative gingivitis superimposed on rapidly progressive periodontitis
  • Other symptoms include:
    ◦ Interproximal necrosis and cratering
    ◦ Marked swelling
    ◦ Intense erythema over the free and attached gingiva
    ◦ Intense pain
    ◦ Spontaneous bleeding and bad breath
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12
Q

Candidiasis

A

Candidiasis is often the initial oral sign of progression from HIV-positive status to AIDS
* In a patient with a compromised immune system, candidiasis can be a very debilitating and serious disorder

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13
Q

Cervical Lymphadenopathy

A

Enlargement of the cervical (neck) nodes
-Lymphadenopathy is frequently seen in association with AIDS

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14
Q

Lymphoma

A
  • Lymphoma is the general term used to describe malignant disorders of the lymphoid tissue
  • In the immunocompromised individual, it may occur as a solitary lump or nodule, a swelling, or a nonhealing ulcer that occurs anywhere in the oral cavity
  • The swelling may be ulcerated or may be covered with intact, normal-appearing mucosa
  • Usually painful, the lesion grows rapidly and may be the first evidence of lymphoma
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15
Q

Hairy Leukoplakia

A
  • Can be an imporant early manifestation of AIDS
    -* A filamentous white plaque usually found
    unilaterally or bilaterally on the lateral borders
    (sides) on the anterior portion of the tongue
  • May spread to cover the entire dorsal surface of
    the tongue
  • Can also appear on the buccal mucosa, where it
    generally has a flat appearance
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16
Q

Kaposi Sarcoma = HIV POSITIVE

A
  • One of the opportunistic infections that occurs in patients with HIV infection
  • Lesions may appear as multiple bluish, blackish, or reddish blotches that are usually flat in the early stages
  • Kaposi sarcoma is one of the intraoral lesions that is used to diagnose AIDS
  • can be intra or extra oral
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17
Q

Herpes Simplex

A
  • Herpes simplex lesions usually occur on the lip
  • In immunocompromised patients, the lesions may occur throughout the mouth
  • An ulcer caused by the herpes virus that persists for longer than 1 month may be an indicator of AIDS
  • Patients who do not have HIV or AIDs may also suffer from herpes
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18
Q

Human Papillomavirus

A

Human papillomavirus appears most commonly in immunocompromised individuals * Diagnosis is made on the basis of history, clinical
appearance, and biopsy findings
* Lesions are a common finding in patients with early HIV infection
* These warts appear spiky, and some have a raised, cauliflower-like appearance

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19
Q

Oral Cancer

A

One of the 10 most frequent cancers in the world
* The incidence, as well as the site, of the cancer varies greatly from country to country
* Most oral cancers do not cause pain in the early stages, and the thorough dentist is most likely to be the first to detect them
* These cancers are fatal if not detected early enough or if left untreated

  • cell proliferating abnormally, when multiple cells are mutated
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20
Q

Oral Cancer - Canada Stats

A
  • According to the Canadian Cancer Society (2024a): ◦ It is estimated that in 2024:  8,100 Canadians will be diagnosed with head and neck cancer.
     2,100 Canadians will die from head and neck cancer.  5,800 men will be diagnosed with head and neck cancer and 1,550 will die from it.
     2,300 women will be diagnosed with head and neck cancer and 590 will die from it.
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21
Q

What is Cancer?

A

-Cells in the mouth sometimes change and no longer grow or behave normally

  • these changes may lead to non-cancerous (benign) tumours such as warts and fibromas
  • Changes to cells of the mouth can also cause precancerous conditions.
  • This means that the abnormal cells are not yet cancer, but there is a chance that they may become cancer if they aren’t treated.
  • The most common precancerous conditions of the mouth are leukoplakia (white) and erythroplakia (red)
22
Q

Erythroplakia

A
  • Erythroplakia is a flat or slightly raised, red area
    that often bleeds easily if it is scraped.
  • Erythroleukoplakia is a patch with both red and
    white areas
23
Q

Squamous Cell Carcinoma

A
  • In some cases, changes to the cells of the mouth
    can cause oral cancer. * The oral mucosa is made up of squamous cells
    called the squamous epithelium. * Most often, oral cancer starts in these flat, thin
    squamous cells. * This type of cancer is called squamous cell
    carcinoma of the mouth
24
Q

Carcinoma means..

A

Malignant neoplasm (growth) of the epithelium (tissue lining the mouth)

25
Q

Adenocarcinoma

A

Malignant tumor that arises from the submucous glands underlying the oral mucoasa

26
Q

Sarcoma means..

A

Malignant neoplasm arising from supportive and connective tissue

27
Q

Osteosarcoma means..

A

Malignant tumor involving the bone
- the mouth, the affected bones are the bones of the jaws

28
Q

Leukemia

A
  • A cancer of the blood-forming organs
  • Characterized by rapid growth of immature white blood cells
  • Oral symptoms of leukemia may be some of the first indications of the disease
  • Symptoms in the gingival tissues include hemorrhage, ulceration, enlargement, spongy
    texture, and magenta coloration of the gingiva
  • Enlargement of lymph nodes, symptoms of anemia, and general bleeding tendencies are typical
29
Q

Rare Types of Oral Cancer

A
  • Salivary gland cancer
  • Melanoma
  • Bone and soft tissue carcinoma
  • Lymphoma
30
Q

Metastasize

A
  • Cancer spreads to other regions of the body
    -Oral Cancer - usually spreads to the neck and cervical lymph nodes
31
Q

Appearance of Early Cancer

A

*White areas
* Red areas
* Ulcers
* Masses - lumps or bumps
* Pigmentation

32
Q

Warning Signs for Oral cancer..

A
  • Early stages – not painful
  • Sore that does not heal
  • Any lump or swelling on the neck, lips, or oral cavity
  • White or rough textured lesions on the lips or oral cavity
  • Numbness in or around the oral cavity
  • Dryness in the mouth for no reason
  • Burning sensation or soreness for no reason
  • Repeated bleeding in a specific area for no reason
  • Difficulty speaking, chewing or swallowing
33
Q

Etiology of Cancer

A
  • Exact etiology unknown
  • Changes (mutations) to the DNA within cells - can cause the cell to stop its normal function and may allow a cell to become cancerous.
34
Q

Risk Factors of Oral Cancer

A
  • Tobacco and alcohol use.
    ◦ Most cases of oral cancer are linked to cigarette smoking,
    heavy alcohol use, or the use of both tobacco and alcohol together.
    ◦ Using tobacco plus alcohol poses a much greater risk than using either substance alone * Betel nut chewing and areca nut
  • HPV ◦ Infection with the sexually transmitted human papillomavirus (specifically HPV 16 and 18) has been linked to a subset of oral cancers.
  • Previous cancer
  • Family history of squamous cell carcinoma
  • Sun exposure. ◦ Cancer of the lip can be caused by sun exposure.
  • Diet and nutrition ◦ A diet low in fruits and vegetables may play a role in oral cancer development
  • Weakened immune system
  • Graft-versus- host disease
  • Lichen Planus - white web like structure
  • Poor oral health
  • Inherited conditions
    ◦ Fanconi amenia
    ◦ Dyskeratosis congenital
35
Q

Smokeless Tobacco

A
  • Chewing tobacco or snuff presents a serious health hazard
  • It is a major concern because of the high rates of precancerous leukoplakia and oral cancer among users of smokeless tobacco
  • Cancers of the pharynx, larynx, and esophagus occur 400 to 500 times more frequently in users of smokeless tobacco
  • Also linked to an increased incidence of tooth loss
    from periodontal disease
36
Q

Possible Risk Factors of Oral Cancer

A
  • Poor fitting dentures
  • Drinking very hot beverages
37
Q

Unknown Risk Factors of Oral Cancer

A
  • using alcohol-based mouthwash
  • smoking cannabis (marijuana)
  • infection with human immunodeficiency virus (HIV) or having acquired immunodeficiency syndrome (AIDS)
38
Q

Vaping and Oral Cancer

A
  • The long-term effects of vaping on general and oral health are not yet known.
  • Current evidence suggests that vaping is a gateway to conventional cigarette smoking and may increase the risk of heart damage and stroke in similar ways to cigarette smoking
  • Vaping has also been linked to cases of acute lung disease, some of which have been fatal
  • The specific risks of vaping liquids containing nicotine or cannabis on oral health are unknown but may be similar to that of tobacco products
39
Q

Cannabis & Oral Cancer

A
  • Cannabis smoking can result in periodontal complications, xerostomia (dry mouth),
    leukoplakias as well as increased risk of oral cancers.
  • Cannabis contains many of the same carcinogens as tobacco.
  • Cannabis is often smoked in combination with tobacco, which complicates attributing causality of resulting disease
40
Q

Detection of Cancer

A
  • Complete head and neck exam
  • Imaging
    ◦ X-rays (panorex) ◦ Chest x-ray
    ◦ Computed tomography (CT or CAT Scan) ◦ Magnetic resonance imaging (MRI) ◦ PET Scan
    ◦ Ultrasound
  • Panendoscopy
41
Q

Detection of Oral Cancer

A
  • Biopsy
    ◦ Incisional biopsy - slice of lesion
    ◦ Excisional biopsy
    ◦ Punch biopsy - punch a piece of skin out
    ◦ Fine needle aspiration - test fluid inside of lump, extract the solution
    ◦ Exfoliative cytology - scrape the lesion
  • Lab tests of biopsy samples
  • HPV 16 testing
  • Toluidine blue staining ◦ uses a dye to check for abnormal areas in the oral cavity
  • Tissue Fluorescence Visualization ◦ uses a special light to find abnormal cells in the oral cavity
    ◦ Velscope
42
Q

Treatment

A
  • Surgery
  • Radiation therapy
    ◦ Affects salivary glands, blood vessels and bones of the jaw
    ◦ Patients who receive this type of treatment may develop dental problems
     Xerostomia
     Radiation mucositis
  • Chemotherapy
  • Combination of all three
43
Q

Dental Implications of Radiation Therapy

A
  • Xerostomia
    ◦ Lack of adequate saliva and the reduced blood supply can cause oral infections, delay healing, and make it very difficult to wear dentures
  • Radiation caries
    ◦ Caused by the lack of saliva, radiation caries usually appears first in the cervical areas of the teeth
    ◦ The teeth also may become extremely sensitive to hot and cold stimuli
  • Osteoradionecrosis
    ◦ Bone may be subject to necrosis (death) after radiation
    treatment
44
Q

Dental Implications of Chemotherapy

A

Chemotherapeutic agents are powerful drugs that destroy or deactivate rapidly dividing cancer cells
* Significant adverse effects of these drugs frequently involve the oral tissues
◦ Mucositis
◦ Aphthous ulcers
◦ Transient reactions
◦ Xerostomia
◦ Delayed healing
◦ Dental malformation

45
Q

Oropharyngeal Cancer

A

-Emerging Threat..
*Rates of head and neck cancers are increasing and are set to continue growing
-An increased number are caused by the human papillomavirus (HPV)

46
Q

HPV

A

-human papillomavirus (HPV) is a DNA virus that belongs to the papilomaviridae family
-frequently sextually transmitted, causing infections which hace an incubation period varying from three weeks to an inderminate length of time
-HPV is spread through initmate skin to skin contact
* Oral HPV is transmitted to the mouth by oral sex
* Most people clear the HPV virus in one to two year
* Can persist in some people, causing cancer in the oropharynx area
* HPV is thought to cause 60-70% or oropharyngeal cancers in the US

47
Q

Type of HPV..

A
  • More than 100 types of HPV
  • Only a few are high risk for oral cancer ◦ Primarily HPV-16 and HPV- 18 (over 90% of HPV positive oral cancers are HPV 16 positive) ◦ HPV-6 and, 11 are related to veneral warts and present ithe oral cavity as condyloma acuminatum
48
Q

Condyloma Acuminatum

A
  • Clusters of multiple, pink, slightly papillary nodules attached with a broad base
  • Painless, persistent
  • Common in young adults
49
Q

Symptoms of HPV-Related Head and
Neck Cancers

A
  • A sore, or soreness or irritation that doesn’t go away
  • Red or white patches, or pain, tenderness, or numbness in mouth or lips
  • Lumps, thickening tissues, rough spots, crusty or eroded areas
  • Difficulty chewing, swallowing, speaking or moving your jaw or tongue
  • A change in the way your teeth fit together when you close your mouth
50
Q

Preventing HPV infection

A
  • Limited sexual partners
  • Using condoms/dental dams
  • Pap tests
  • Vaccinations
51
Q

Lowering risk of Oropharyngeal Cancer

A
  • Alcohol and tobacco products may contribute to
    oropharyngeal cancers
52
Q
A