Anaphylaxsis Flashcards
Define an “allergic reaction”.
When the body’s immune system over reacts to a substance.
What are anti-bodies produced by?
Immunoglobulin E
Define “Anaphylaxis”
A Severe, life threatening, generalised or systemic hypersensitivity reaction.
What % of the population have allergies?
30%
What % of the population suffer from anaphylaxis?
2%
What are the 2 types of cells involved in anaphylaxis?
- Basophillls
- Mast cells
What is a Basophil?
A type of white blood cell which migrates to sites of immflamtion, and travel from capillaries to the tissue.
What is released by basophills?
- Heparin,
- Histamine
- Seratonin
What is a Mast cell?
Connective tissue cells prominent in tissues that are exposed to the outside world.
What does Calcium cause?
Cellular contractions
What hormone binds to mast and basophillls during the initial stages of anaphylaxis?
Immunogloblin E
What enzyme is activated during anaphylaxis?
Tyrosine Kinase
What is caused by Histamine?
- Vasodilation
- Increased vascular permeability
- Tachycardia
- Increased contraction
- Increased glandular secretion
What is caused by Prostaglandin D2?
- Bronchoconstriction
- Pulmonary and vasoconstriction
- Peripheral vascular dilation
What is caused by Leukotrienes?
- Bronchoconstrction
- Increased vascular permeability
- Release of platelet activating factor
- Increased vascular permeability
