Adaptive Immunity: Cell Mediated Immunity (T Cells) Flashcards
Roles of T cell
Able to look inside cell to get rid of infectious material
Prevention and destruction of cancer
2 types of T cells
Helper T cell : activates other cells
Cytotoxic t lymphocytes: destroy tumor cell
T cells develop
In the thymus gland. Born in bone marrow and mature in thymus. Where they are taught what is good.
What would happen if someone doesn’t have a thymus
A lot of auto immune diseases.
Major histocompatibility complex
MHC holds and presents chopped up pieces of antigens
MHC1
MHC2
Apc
Antigen presenting cell
Dendritic cells in skin and urinary tract. Many cell types take on this role. Macrophage both use MHC2 to show epitope to T cells
MHC 1
Presents self antigens from within cell. Cytotoxic T cell that is going to kill they cell that they interact with
MHC2
Presents antigens that were detected outside the cell (pathogens)
• helper T cells that activate the rest of the immune system
Describe the handshake between T cell and cell presenting antigen
The T cell receptor (TCR) shakes hand with the major histocompatibility complex (MHC) So if the T cell recognizes a particular antigen it may activate and do it’s job
CD
Clusters of differentiation: proteins found on surface of cells that correspond to unique cell types in the body
Cd 4
Immature T cell that turns into Helper T cells
By being presented proper antigen found from outside cell by MHC 2
*activates immune system like B cells by releasing protein interleukins and cytokines
CD 8
Immature T cell that turns into Cytotoxic t cells that kill using perforin to open pore in surface, sends granzyme protein, that causes apoptosis.
MHC 1
Internally produced antigens
( cancer)
Labeling
From affected cell presents antigen with MHC1 or 2.
• reads with TCR (t cell receptor) held together by CD8 or 4
