ACS PHARMACOLOGY

Question 1

action of aspirin

Answer 1

inhibits thromboxane 2

Question 2

action of clopidogrel

Answer 2

inhibits ADP receptor

Question 3

when should thrombolysis be done

Answer 3

if invasive procedure cannot be done within 120 minutes

Question 4

what is the action of thrombolytic drugs ?

Answer 4

converts plasminogen into plasmin
which converts insoluble fibrin to soluble fbrinogen

Question 5

fibrin specific drugs

Answer 5

Alteplase ​

Tenecteplase – Tenecteplase is a mutated form of alteplase with higher fibrin specificity and a longer half-life of elimination and is usually administered as a bolus infusion, whereas alteplase is usually administered as a 2-hour continuous infusion.​

Question 6

non specific fibrin drugs

Answer 6

Streptokinase – Lower efficacy but lower bleeding risk​

Recently utilised due to worldwide shortage of Alteplase/Tenecteplase.

Question 7

contraindications of thrombolysis

Answer 7

recent surgery
stroke
high blood pressure
prior intracranial haemorrhage
suspected aortic dissection