(8) Pain SLO Flashcards
1
Q
Acetaminophen is associated with \_\_?\_\_. A. Bronchoconstriction B. Liver failure C. Urticaria D. Reye’s Syndrome E. Hyperkalemia
A
Liver Failure
2
Q
Aspirin is associated with \_\_?\_\_ in kids with viral infections. A. Reye’s Syndrome B. GIT ulcers C. Respiratory distress Syndrome D. Urticaria E. Constipation
A
Reye’s Syndrome
3
Q
Aspirin is associated with \_\_?\_\_ A. Gastric ulcers B. Respiratory distress Syndrome (bronchoconstriction) C. Urticaria D. Tinnitus E. All the above
A
Gastric ulcers Respiratory distress Syndrome (bronchoconstriction) Urticaria Tinnitus **ALL**
4
Q
Aspirin is contraindicated in young patients with chicken pox or influenza due to the risk of \_\_?\_\_ A. Reye’s Syndrome B. Heart Attack C. Gastric ulcer D. Nose bleed E. Asthma attack
A
Reye’s Syndrome
5
Q
Etanercept, and other biologic response modifier or disease-modifying antirheumatic drugs (DMARDs) and other immune modulators, are associated with __?__.
A. Fewer infections
B. Antibiotic effects
C. Increased risk of malignancy
D. No change in immune response
E. An increased risk of serious infection and pancytopenia
A
An increased risk of serious infection and pancytopenia
6
Q
Fentanyl and morphine have short t ½ so are used to treat acute or break through pain, whereas \_\_?\_\_ has a very long t ½ so is used for chronic pain. A. Pentazocine B. Hydrocodone C. Meperidine D. Naltrexone E. Methadone
A
Methadone
7
Q
Hydrocodone is metabolized by CYP2D6 to morphine, genetic expression varies. Having multiple copies of the gene would predispose the patient to \_\_?\_\_ related side effects? A. Cocaine B. Morphine C. Aspirin D. Acetaminophen E. Fentanyl
A
Morphine
8
Q
NSAIDs are associated with \_\_?\_\_. A. GIT ulcers B. GIT pain, nausea and aggravation of pre-existing GIT diseases C. Urticaria D. Worsening congestive heart failure E. All the above
A
GIT ulcers GIT pain, nausea and aggravation of pre-existing GIT diseases Urticaria Worsening congestive heart failure **ALL**
9
Q
Opioids are associated with __?__
A. Progressively decreased responsiveness so more drug is needed to get same effect.
B. Causing an overwhelming desire to take the drug
C. Tolerance
D. Dependence
E. All the above
A
Progressively decreased responsiveness so more drug is needed to get same effect.
Causing an overwhelming desire to take the drug
Tollerence
Dependence
ALL
10
Q
Probenecid (Benuryl) increases the \_\_?\_\_ of penicillin antibiotics, sulfonamides and sulfonylureas. A. Renal secretion B. Plasma concentration C. Kidney excretion D. Plasma protein binding E. Liver metabolism
A
Plasma consentration
11
Q
Which is a synthetic opioid analgesic available PO, SC, IV, IM, PR, sublingual, and buccal for moderate to severe pain? T ½ is 5-7 hours. It is NOT CONTROLLED. A. Methadone B. Tramadol C. Pentazocine D. Meperidine E. Buprenorphine
A
Tramadol (Ultram)
12
Q
Which blocks renal tubular reabsorption of urate? It is used to increase uric acid excretion, to treat gout, and to decrease the renal secretion of penicillin antibiotics. A. Rasburicase B. Etanercept C. Colchicine D. Probenecid E. Allopurinol
A
Probenecid (Benuryl)
13
Q
Which is a C-II opioid analgesic used PO, IM, IV, PR, epidural, and intrathecal with a t ½ of 1.5-7 hours to relieve moderate to severe pain? It is derived from the poppy and is commonly used in patient controlled analgesia devices (PCA). A. Hydrocodone B. Fentanyl C. Morphine D. Diphenoxylate E. Naltrexone
A
Morphine (MS Contin)
14
Q
Which is a C-II synthetic opioid analgesic available PO, IV, and IM for acute pain and obstetric or post-op analgesia? T ½ is about 3-4 hours. It has a boxed warning limiting use to less than 12 weeks. A. Meperidine B. Fentanyl C. Methadone D. Morphine E. Buprenorphine
A
Meperidine (Demerol)
15
Q
Which is a C-II synthetic opioid analgesic available PO, IV, IM, SC (IM and SC not preferred) to treat chronic pain, opioid addiction and as an antitussive? T ½ highly variable 24-60 hours. A. Morphine B. Fentanyl C. Buprenorphine D. Methadone E. Meperidine
A
Methadone (Dolophine, Methadose)
16
Q
Which is a C-II synthetic opioid analgesic indicated for chronic pain, MI and cancer, including breakthrough pain associated with injuries and cancer. IV, IM, PO, TD, sublingual & buccal formulations are available & the t ½ is about 7 hours. A. Buprenorphine B. Hydrocodone C. Fentanyl D. Methadone E. Morphine
A
Fentanyl (Duragesic)
17
Q
Which is a C-III synthetic opioid analgesic available sublingual (film and pills), TD, IM, and IV to treat moderate to severe chronic pain, opioid dependence and as a peri-op analgesic? T ½ is around 37 hours, but can be up to 70 hours. A. Fentanyl B. Methadone C. Meperidine D. Buprenorphine E. Morphine
A
Buprenorphine (Buprenex, Suboxone)
18
Q
Which is a C-IV synthetic opioid analgesic available IV, SC, IM and PO (formulated with naloxone to prevent abuse)? It is indicated for mild to moderate pain and as a pre-anesthetic or supplement to general anesthetic. T ½ is 2-3 hours. A. Meperidine B. Buprenorphine C. Methadone D. Fentanyl E. Pentazocine
A
Pentazocine (Talwin)
19
Q
Which is a C-V if compounded with atropine (C-II without). It is a congener of meperidine used PO as an antidiarrheal. The t ½ is 12-14 hours. A. MS-Contin B. Lomotil C. Revia D. Vicodin E. Duragesic
A
Lomotil (Diphenoxylate + atropine)
20
Q
Which is a CIII semi-synthetic opioid analgesic and antitussive? In the US, it is always compounded with something else like APAP or Atropine. It is given PO and the T ½ is about 4 hours. A. Fentanyl B. Morphine C. Diphenoxylate D. Hydrocodone E. Naltrexone
A
Hydrocodone
21
Q
Which is a COX2 inhibitor NSAID indicted for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute pain, dysmenorrhea and colorectal polyps in Familial Adenomatous Polyposis (FAP). PO Only A. Aspirin B. Celecoxib C. Acetaminophen D. Ibuprofen E. Paracetamol
A
Celecoxib (Celebrix)
22
Q
Which is a glucosaminoglycan indicated to replace naturally occurring glucosaminoglycans in wounds (as wound dressing), and in osteoarthritis and eye surgery as well as to smooth out facial wrinkles and to treat dry, scaly skin? A. Aspirin B. Rasburicase C. Ibuprofen D. Hyaluronic acid E. Acetaminophen
A
Hyaluronic Acid (Hyalgan)
23
Q
Which of the following is a mitotic spindle poison used to treat gout? A. Allopurinol B. Colchicine C. Rasburicase D. Probenecid E. Aspirin
A
Colchicine (Colcyrus)
24
Q
Which is a salicylate NSAID? A. Aspirin B. Acetaminophen C. Paracetamol D. Celecoxib E. Ibuprofen
A
Aspirin
25
Q
Which is a Tissue necrosis factor alpha (TNF-alpha) inhibitor indicated to treat rheumatoid conditions? Only available SC. A. Etanercept B. Enbrel C. Hyaluronic acid D. A & B E. A & C
A
Etanercept (Enbrel)
BOTH
26
Q
Which is a Xanthine oxidase inhibitor that blocks urate synthesis to treat gout? It is also used to treat the hyperurecemia associated with certain cancer chemotherapeutic agents. A. Probenecid B. Colchicine C. Caffeine D. Allopurinol E. Rasburicase
A
Allpurinol (Zyloprim)
27
Q
Which is an antipyretic analgesic AKA APAP? A. Paracetamol B. Acetaminophen C. N-acetyl-para-aminophenol D. Tylenol E. All the above
A
Tylenol Acetaminophen Paracetamol N-acetyl-para-aminophenol ***ALL***
28
Q
NSAIDs are associated with __?__.
A. Water loss (diuresis)
B. Salt loss
C. Salt loss and water retention
D. Salt and water retention leading to edema and hyperkalemia
E. Salt retention leading to hyperkalemia and water loss
A
Salt and water retention leading to edema and hyperkalemia
29
Q
NSAIDs are associated with \_\_?\_\_. A. Urticaria B. Bronchoconstriction C. Tinnitus D. Gastric ulcers E. All the above
A
All the above
30
Q
Opioids are associated with \_\_?\_\_. A. CNS depression B. Sedation C. Constipation D. Respiratory depression E. All the above
A
All the above
