(10) Sedative to Antipsychotics SLO Flashcards
1
Q
ALL sedative hypnotics cause \_\_?\_\_, some more so than others. Think alcohol intoxication. A. Renal failure B. Steven Johnson‘s Syndrome C. Bad breath D. Blindness E. Drug-induced amnestic state
A
Drug-induced amnestic state
2
Q
Antidepressants and anti epileptic drugs (AEDs) are associated with an increased risk of \_\_?\_\_. A. Suicide B. Early onset Parkinson’s disease C. EPS D. Antimuscarinic symptoms E. Stroke
A
Suicide
3
Q
Antipsychotics are associated with an increased risk of \_\_?\_\_. A. Alopecia B. A withdrawal syndrome in neonates C. Weight loss D. Enhanced alertness E. Bone cancer
A
Withdrawal syndrome in neonates
4
Q
Benzodiazepines, non-benzodiazepine sedative hypnotics and barbiturates all cause \_\_?\_\_. A. Tolerance B. Dependence C. Withdrawal Syndrome D. Some degree of amnesia E. All the above
A
All of the above
5
Q
Benzodiazepines, non-benzodiazepine sedative hypnotics and barbiturates all have \_\_?\_\_. A. Antimuscarinic symptoms B. A risk of EPS C. Control schedule I listing D. A Withdrawal syndrome. E. A Narrow therapeutic margin
A
A withdrawal syndrome
6
Q
Beta blockers have \_\_?\_\_. A. A Narrow therapeutic margin B. A Withdrawal syndrome C. A risk of EPS D. Antimuscarinic symptoms E. Control schedule I listing
A
A withdrawal syndrome
7
Q
Don’t take zolpidem __?__
A. With water
B. At bedtime
C. With food or immediately after a meal
D. None of the answers listed is correct.
E. After bathing
A
With food or immediately after a meal
8
Q
Elderly patients with dementia-related psychosis are more likely to \_\_?\_\_ when given antipsychotics - hence the boxed warning on all antipsychotics. A. Have kidney problems B. Have liver problems C. Have cardiovascular problems D. Die E. Improve
A
Die
9
Q
Having the HLA-B 1502 allele (a variant of the HLA-B gene) predisposes patients on carbamazepine to \_\_?\_\_ A. Blood dyscrasias B. Steven Johnson’s Syndrome C. Epilepsy D. Heart disease E. Psychosis
A
Steven Johnson’s Syndrome
10
Q
Lithium causes goiter because it \_\_?\_\_. A. Has antimuscarinic symptoms B. Has a Narrow therapeutic margin C. Causes weight gain D. Has a Withdrawal syndrome. E. Inhibits the release of thyroid hormone
A
Inhibits the release of thyroid hormone
11
Q
Lithium causes \_\_?\_\_. A. Tremor B. Hair loss C. Weight gain D. Memory loss E. All the above
A
All the above
12
Q
Lithium has \_\_?\_\_. A. None of the listed answers is correct. B. Anticholinergic effects C. A lifetime maximum dose D. A Narrow therapeutic margin E. A Control Schedule 1 listing
A
A Narrow therapeutic margin
13
Q
MAOIs are associated with \_\_?\_\_. A. Neuroleptic malignant syndrome B. Tolerance C. Malignant hyperthermia D. Serotonin syndrome E. Dependence
A
Serotonin Syndrome
14
Q
Phenobarbital has a long t ½ and is often associated with \_\_?\_\_. A. Insomnia B. Angina C. Seizures D. Hang-over E. Arrhythmias
A
Hang-over
15
Q
Phenobarbital is a potent \_\_?\_\_ A. P450 inducer B. Benzodiazepine C. TCA D. SNRI E. SSRI
A
P450 inducer
16
Q
SSRIs have \_\_?\_\_. A. A Withdrawal syndrome. B. A risk of EPS C. A Narrow therapeutic margin D. Control schedule I listing E. Analgesic effects
A
A withdrawal syndrome
17
Q
TCAs are contraindicated with \_\_?\_\_ because the combination may cause hyperpyretic crises, convulsions and fatalities. A. MAOIs B. Non-BZD hypnotics C. BZDs D. Antihistamines E. Barbiturates
A
MAOIs
18
Q
The most commonly prescribed antidepressants, including SNRIs and SSRIs, are associated with \_\_?\_\_ A. Weight gain B. Delayed onset (oftentimes weeks) C. All the above D. Sexual dysfunction E. Potential effects on clotting
A
All the above
19
Q
The onset of action for Eszopiclone is so rapid, it must be taken immediately before \_\_?\_\_. A. Bathing B. Drinking water C. Going to bed D. Eating E. Getting up in the morning
A
Going to bed
20
Q
Typical antipsychotics are associated with a greater risk of \_\_?\_\_ than atypicals. A. Sedation B. Anticholinergic effects C. EPS D. Sympathetic effects E. All the above
A
All the above
21
Q
When neonates have been exposed to antipsychotics during the 3rd trimerster of pregnancy, they are at increased risk of \_\_?\_\_. A. Goiter B. Hair loss C. Weight gain D. A Withdrawal syndrome. E. Cataracts
A
A withdrawal syndrome
22
Q
Which of the following is a 1st generation antihistamine used as a sedative, hypnotic, and to treat all allergic reactions and motion sickness as well as Parkinson’s movement disorders and EPS. A. Divalproex B. Diphenhydramine C. Lamotrigine D. Lithium E. Carbamazepine
A
Diphenhydramine
23
Q
Which of the following is a 1st generation antihistamine with anti cholinergic effects indicated to treat all allergic reactions, as a sedative/hypnotic and to treat PD/EPS? A. Buspirone B. Artane C. Benztropine D. Bupropion E. Benadryl
A
Benadryl
24
Q
Which of the following is Desyrel, a 5HT antagonist and Reuptake Inhibitor (SARI) used PO to treat MDD? A. Benztropine B. Bupropion C. Trazodone D. Buspirone E. Selegiline
A
Trazadone
25
Q
Which of the following is a 5HT1a agonist and a D2 antagonist, non-sedating anxiolytic? A. Buspirone B. Zolpidem C. Eszopiclone D. Phenobarbital E. Propranolol
A
Buspirone
26
Q
Which of the following is a Beta blocker and non-sedating anxiolytic indicated for HT, angina, performance anxiety, migraine, etc. A. Propranolol B. Carbamazepine C. Lamotrigine D. Lithium E. Doxepin
A
Propranolol
27
Q
Which of the following is a Butyrophenone (typical) antipsychotic given PO and IM to treat schizophrenia and Tourette’s disorder. It may be used off label as an antiemetic. A. Clozapine B. Olanzapine C. Quetiapine D. Chlorpromazine E. Haloperidol
A
Haloperidol
28
Q
Which of the following is a C-III barbiturate sedative hypnotic? A. Thiopental (Pentothal) B. Phenobarbital C. Eszopiclone D. Diphenhydramine E. Buspirone
A
Thiopental (Pentothal)
29
Q
Which of the following is a C-IV barbiturate sedative, hypnotic, AED? A. Phenobarbital B. Diphenhydramine C. Zolpidem D. Buspirone E. Propranolol
A
Phenobarbital
30
Q
Which of the following is a C-IV benzodiazepine (BZD) anxiolytic that is short-acting with active metabolites? Available PO only. T ½ varies from 6-24 hours, averaging about 12 hours. A. Alprazolam B. Midazolam C. Carbamazepine D. Diazepam E. Lorazepam
A
Alprazolam
31
Q
Which of the following is a C-IV BZD long-acting with active metabolites with many indications including acute alcohol withdrawal, epilepsy, tremors, athetosis, sedative/hypnotic, and it is used as an anxiolytic. Available PO, PR, IV, IM and the t ½ ranges from 24-60 hours and up to 10 days! A. Alprazolam B. Lorazepam C. Carbamazepine D. Diazepam E. Midazolam
A
Diazepam
32
Q
Which of the following is a C-IV BZD, it is short-acting with sedative, anxiolytic, amnesiac preanesthetic and status epilepticus control indications. A. Phenobarbital B. Carbamazepine C. Lorazepam D. Diazepam E. Alprazolam
A
Lorazepam
33
Q
Which of the following is a C-IV BZD? It is very short-acting without important active metabolites. Indications include sedation, anxiolysis and amnesia preanesthesia and induction of anesthesia. Available PO, IM, and IV with a t ½ of about 2.5 hours. A. Alprazolam B. Carbamazepine C. Lorazepam D. Diazepam E. Midazolam
A
Midazolam
34
Q
Which of the following is a C-IV non-BZD sedative hypnotic indicated for short-term use to treat insomnia. Available PO only with a t ½ of 2-2.5 hours. A. Propranolol B. Diazepam C. Phenobarbital D. Buspirone E. Zolpidem
A
Zolpidem
35
Q
Which of the following is a C-IV non-BZD sedative hypnotic indicated for short-term use to treat insomnia. It has such a rapid onset of action, it must be taken immediately before bed, preferably on an empty stomach. A. Phenobarbital B. Eszopiclone C. Propranolol D. Diphenhydramine E. Buspirone
A
Eszopiclone
36
Q
Which of the following is a Mood stabilizer for bipolar disorder (antimanic). VERY NARROW THERAPEUTIC MARGIN – therapeutic doses may be toxic. A. Lamotrigine B. Propranolol C. Carbamazepine D. Lithium E. Doxepin
A
Lithium
37
Q
Which of the following is a Phenothiazine (typical) antipsychotic given PO, IV or IM. Indications and uses include schizophrenia, nausea and vomiting control, anxiety, acute intermittent porphyria, adjunct to tetanus therapy, control of the manic phase of bipolar disorder, hiccups, severe behavior problems in kids marked by explosive and/or hyperactive behaviors and for the short-term treatment of ADHD kids with aggression, mood lability, etc. A. Doxepin B. Chlorpromazine C. Risperidone D. Carbamazepine E. Clozapine
A
Chlorpromazine
38
Q
Which of the following is a PO antiviral indicated to treat PD and Influenza A? A. Ambien B. Amantadine C. Ativan D. Artane E. Alprazolam
A
Amantadine
39
Q
Which of the following is a synthetic antispasmodic indicated to treat PD and EPS. Given PO only. A. Ativan B. Artane C. Alprazolam D. Amantadine E. Ambien
A
Artane
40
Q
Which of the following is a TCA given PO for MDD? A. Remeron B. Paxil C. Zoloft D. Pamelor E. Cymbalta
A
Pamelor
41
Q
Which of the following is a TeCA given PO for MDD? It is used off label as an antiemetic much like Ondansetron. A. Trazodone B. Mirtazapine C. Bupropion D. Duloxetine E. Selegiline
A
Mirtazapine
42
Q
Which of the following is a trade name for Bupropion? A. Alplenzin B. Wellbutrin C. Zyban D. Chantix E. A, B and C, not D
A
A, B and C, not D
43
Q
Which of the following is an AED indicated for epilepsy and bipolar disorder? PO only. A. Amitriptyline B. Diazepam C. Lamotrigine D. Duloxetine E. Phenobarbital
A
Lamotrigine
44
Q
Which of the following is an AED indicated for epilepsy, migraine and mania? PO only. Other salts include valproic acid and valproate. A. Diazepam B. Duloxetine C. Divalproex D. Diphenhydramine E. Doxepin
A
Divalproex
45
Q
Which of the following is an AED indicated for epilepsy, trigeminal neuralgia, acute manic & mixed episodes of bipolar disorder. Available PO only. A. Lorazepam B. Carbamazepine C. Midazolam D. Diazepam E. Alprazolam
A
Carbamazepine
46
Q
Which of the following is an Anti-cholinergic (combination of atropine and diphenhydramine) indicated to treat PD and EPS? Available PO, IV and IM. A. Bupropion B. Benztropine C. Benadryl D. Artane E. Buspirone
A
Benztropine
47
Q
Which of the following is an Atypical antipsychotic given IM or PO to treat schizophrenia and bipolar disorder? It is used off label as an antiemetic much as Ondansetron would be used. A. Olanzapine B. Clozapine C. Haloperidol D. Risperidone E. Quetiapine
A
Olanzapine
48
Q
Which of the following is an Atypical antipsychotic given PO (only) for treatment resistant schizophrenia and to decrease the risk of suicide? A. Chlorpromazine B. Quetiapine C. Clozapine D. Haloperidol E. Carbamazepine
A
Clozapine
49
Q
Which of the following is an Atypical antipsychotic given PO to treat schizophrenia and bipolar disorder as well as irritability associated with autism? This atypical has a high risk of EPS compared to other atypicals and is associated with a withdrawal syndrome in neonates. A. Quetiapine B. Risperidone C. Clozapine D. Haloperidol E. Olanzapine
A
Risperidone
50
Q
Which of the following is an MAOI available in PO and TD formulations to treat PD and MDD? A. Emsam B. Eldepryl C. Selegiline D. All the above E. None of the above
A
All the above
51
Q
Which of the following is an SNRI given PO and indicated to treat MDD, anxiety, fibromyalgia, and diabetic neuropathic pain? A. Sertraline B. Trazodone C. Mirtazapine D. Duloxetine E. Selegiline
A
Duloxetine
52
Q
Which of the following is an SNRI given PO and indicated to treat MDD. A. Paroxetine B. Trihexyphenidyl C. Haloperidol D. Chlorpromazine E. Venlafaxine
A
Venlafaxine
53
Q
Which of the following is the L isomer of citalopram (the biologically active form), an SSRI given PO for anxiety and MDD? A. Valium B. Lexapro C. Buspar D. Ambien E. Celexa
A
Lexapro
54
Q
Which of the following is the SSRI “Celexa” given PO for MDD? A. Fluoxetine B. Sertraline C. Escitalopram D. Citalopram E. Paroxetine
A
Catalopram
55
Q
Which of the following is the SSRI “Paxil” given PO for MDD and anxiety? A. Citalopram B. Fluoxetine C. Sertraline D. Paroxetine E. Escitalopram
A
Paroxetine
56
Q
Which of the following is the SSRI “Prozac” given PO for MDD, anxiety, and premenstrual dysphoric disorder? A. Paroxetine B. Escitalopram C. Fluoxetine D. Sertraline E. Citalopram
A
Fluoxetine
57
Q
Which of the following is the SSRI ”Zoloft” given PO for MDD, panic disorder, OCD? A. Sertraline B. Escitalopram C. Fluoxetine D. Paroxetine E. Citalopram
A
Sertraline
58
Q
Which of the following is the TCA “Sinequan” given PO for MDD, anxiety, alcoholism or bipolar disorder? A. Duloxetine B. Divalproex C. Diazepam D. Doxepin E. Diphenhydramine
A
Doxepin
59
Q
Which of the following is the TCA “Tofranil” given PO for MDD and childhood enuresis? A. Fluoxetine B. Mirtazapine C. Nortriptyline D. Imipramine E. Citalopram
A
Imipramine
60
Q
Which of the following is the Typical antipsychotic Navane given PO or IM to control schizophrenic behavior? It sometimes turns the urine pink. A. Thiopental B. Topamax C. Tegretol D. Thiothixene E. Thorazine
A
Thiothixene
61
Q
Which of the following is “Seroquel,” an Atypical antipsychotic given PO to treat schizophrenia, MDD and bipolar disorder? Patients must be monitored for cataract development, a risk with this drug. A. Risperidone B. Clozapine C. Quetiapine D. Olanzapine E. Haloperidol
A
Queiapine
62
Q
Which of the following was originally added to patent medicines in the 1800's to treat gout? Even 7-UP originally contained some of this "happy" making mineral. A. Carbamazepine B. Doxepin C. Propranolol D. Lamotrigine E. Lithium
A
Lithium
63
Q
Which of these is an “Other” antidepressant used PO to treat MDD and SAD. The trade names have different indications and one is only used for smoking cessation. A. Selegiline B. Alprazolam C. Trazodone D. Bupropion E. Buspirone
A
Bupropion
64
Q
While all of the benzodiazepines are on the Beer's List, \_\_?\_\_ is a BZD that is replacing diazepam to sedate elderly people due to the fact that it has no active metabolites and it is short acting. A. Lorazepam B. Haloperidol C. Zolpidem D. Olanzapine E. Citalopram
A
Lorazepam
65
Q
Women and the Elderly/debilitated patients/hepatic impaired, should be given \_\_?\_\_ the normal zolpidem or eszopiclone dose. A. Twice B. ¼ C. Triple D. More than E. Half
A
Half
66
Q
Which of the following is the TCA “Elavil” given PO for MDD? A. Duloxetine B. Clozapine C. Selegiline D. Alprazolam E. Amitriptyline
A
Amitriptyline
