66. Pathologic pigmentation caused by hemoglobin and haemosiderin

Question 1

Haemoglobin

Answer 1

Result of Hb being released from haemolysed RBCs

Question 2

Give the causes of haemolysis

Answer 2

• Autointoxication
• Chemicals
• Drugs
• Physical effects
• Pathogens
• Plant poisons

Question 3

Hemosiderin

Answer 3

Brown, iron containing , granular pigment
developes in macrophage

Question 4

Hemosiderin: Histology

Answer 4

• Prussian blue (Perl’s reaction)
• Turnbulls technique

Question 5

Forms of hemoglobin

Answer 5

• Sulfhaemoglobin: Greenish → Fades
• Methaemoglobin : Dark brown (nitrate posioning)
• Carboxi-haemoglobin: Cherry pink discolouration, clearly visible in the brain

formalin pigment: dark brown