63. Degeneration changes of cells and tissue

Question 1

Intracellular Changes:

Answer 1

1. Organelle Damage→ Enzyme leakage, vacuole formation, necrosis

2. Metabolite Accumulation → Mitochondrial damage, fat/glycogen depletion

3. Nuclear Damage:
* Karyopyknosis (nuclear shrinks).
* Karyorrhexis (nuclear fragmentation).
* Karyolysis (nuclear dissolution).

4. Cell Death.

Question 2

Tissue change

Answer 2

ECM Degeneration → Loss of essential components
.
Fibrovascular Degeneration→ Poor blood supply, connective tissue breakdown.

Atrophy →Reduced cell mass & tissue volume.