65. Hyalinosis, fibrinoid necrosis

Question 1

Hyalinosis

Answer 1

Abnormal accumulation of hyaline

Question 2

Hyalinosis

Physiological

Answer 2

Occurs in small blood vessels (e.g., aging).

Question 3

Hyalinosis

Pathological

Answer 3

CT Origin: Swollen matrix, common in tissue necrosis (e.g., sepsis).

Cellular Origin:
* Epithelial → Hyaline droplet degeneration in renal tubules.
* Hyperactive Plasma Cells→ Russell bodies.

Haematogenic Origin:
* Hyaline in blood vessels, pulmonary alveoli, thrombi, renal tubules, and corpus amylaceum (udder).

Question 4

Fibrinoid Necrosis

Definition:

Answer 4

Protein accumulation causing tissue damage.

Question 5

Fibrinoid Necrosis

cause

Answer 5

Vasculitis → Increased permeability → deposition of proteins in the tissues → Tissue damage

Question 6

Fibrinoid Necrosis

Forms

Answer 6

Blood Vessels→ Fibrin accumulation → Necrosis. irregular, uneven nodules

Connective Tissue→ Swollen collagen fibers, necrosis, inflammation.

Question 7

Fibrinoid Necrosis

Immune-Related

Answer 7

Autoimmune (e.g., rheumatoid arthritis).

Unknown antigen triggers in some cases.