5.4 Thiazide and Thiazide-like Diuretics

Question 1

Thiazide and Thiazide-like Diuretics act mainly in the…

Answer 1

Ascending loop of Henle and early distal tubule

Question 2

The mechanism of action of Thiazide and Thiazide-like Diuretics is…

Answer 2

-Inhibits tubular reabsorption of sodium and chloride ions
-Potassium is also excreted to a lesser extent
- Result: water, sodium, and chloride are excreted

• Dilate the arterioles by direct relaxation

Question 3

Thiazide and Thiazide-like Diuretics drug effects include…

Answer 3

Lowered peripheral vascular resistance
Depletion of sodium and water

Question 4

Effects of Thiazide and Thiazide-like Diuretics on the CNS include…

Answer 4

• Dizziness
• Headache
• Blurred vision
• Paresthesias
• Decrease libido

Question 5

Effects of Thiazide and Thiazide-like Diuretics on the GI tract include…

Answer 5

• Anorexia
• N+V
• Diarrhea

Question 6

Effects of Thiazide and Thiazide-like Diuretics on metabolism include…

Answer 6

Hypokalemia

Question 7

Excessive consumption of what food can lead to an additive hypokalemia in clients taking thiazides?

Answer 7

Licorice