2.2 Non-Opioid Analgesics

Question 1

Non-opioid analgesic definition. What drugs are considered non-opioid analgesics?

Answer 1

Analgesics that are structurally and functionally different from opioids

All drugs in the NSAID class (aspirin, ibuprofen, naproxen) are non-opioid analgesics

Question 2

Acetaminophen. Where is it sold?

Answer 2

A non-opioid analgesic, antipyretic, and mild anti-inflammatory

Solt OTC and in combination with opioids

Question 3

Mechanism of Action

Answer 3

Blocks pain impulses periphally by inhibiting prostaglandin synthesis

Lowers febrile body temperature by acting on the hypothalamus (regulates body temperature)
- heat dissipates through resulting vasodilation and increased peripheral blood flow

Question 4

Indications

Answer 4

Treats mild to moderate pain
Treats fever

Question 5

Contraindications

Answer 5

Known drug allergy
Liver disease
Genetic G6PD enzyme deficiency

Question 6

Adverse effects

Answer 6

Rash
Nausea and vomiting

Blood disorders or dyscrasias
Kidney function when taken with alcohol
Hepatotoxicity

Question 7

Dose

Answer 7

Max 4000 mg/24hr divided into q4-6h doses

Be aware of acetaminophen content of other drugs

Question 8

Toxicity (Antidote?)

Answer 8

Lethal when od (intentional or long-term use)
Long-term large dose leads to nephropathy
(deterioration of kidney function)

Antidote: acetycysteine (mucomyst)