5.3 Potassium-Sparing Diuretics

Question 1

Where do potassium-sparing diuretics work?

Answer 1

In the collecting duct and distal convoluted tubules

Question 2

How do potassium-sparing diuretics work?

Answer 2

Interfere with sodium-potassium exchange by:
- Competitively bind to aldosterone receptors
- Block the resorption of sodium and water usually induced by aldosterone

Question 3

amiloride, spironolactone, and aldactone are examples of…

Answer 3

potassium-sparing diuretics

Question 4

The drug effects of potassium-sparing diuretics include…

Answer 4

Prevent potassium from being pumped into the tubule, thus preventing its secretion

Competitively block the aldosterone receptors and inhibit its action

The excretion of sodium and water
is promoted

Question 5

Spironolactone can be used for…

Answer 5

• Hyperaldosteronism
• Hypertension
• Reversing the potassium loss caused by potassium-losing drugs

Question 6

Amiloride can be used for…

Answer 6

Treatment of congestive heart failure

Question 7

Side effects of potassium-sparing diuretics on the CNS include…

Answer 7

Dizziness, headache

Question 8

Side effects of potassium-sparing diuretics on the GI tract include…

Answer 8

Cramps
N+V
Diarrhea

Question 9

Side effects of potassium-sparing diuretics on the GU system include…

Answer 9

Urinary frequency, weakness

Question 10

Hyperkalemia may occur when potassium-sparing diuretics are used in conjunction with…

Answer 10

Each other
Other potassium-sparing drugs such as ACE inhibitors