3.5 - One Gene to One Protein Hypothesis

Question 1

Who came up the the One Gene to One Protein Hypothesis, in what year, and who was it influenced by?

Answer 1

• Beadle & Tatum
• 1941
• Garrod (1909)

Question 2

What is the overview of the One Gene to One Protein Hypothesis

Answer 2

As genes are expressed, proteins/enzymes are made. From these proteins, it is what determinds our phenotype

Question 3

What disease did Garrod study, and what was his hypothesis?

Answer 3

• he studies a disease that turns the urin black due to a chemical called alkapton
• Hypothesis : there is a gene that carries instructions for making the enzyme. Those with the diease carry a faulty version of the gene which they pass down to their children

Question 4

Breifly describe/ summerize Beadle and Tatum’s experiment (activity we did inclass).

Answer 4

• for breadmold, it’s synthesized from precursor molecules using a sequence of three chemical reactions
• without a certain enzyme, it can’t move on to produce the desired end product
• conclusion: There is one gene to one protein transition