3.3.13.5 Action of Anticancer Drugs Flashcards
1
Q
What is an example of an anticancer drug?
A
Cisplatin
2
Q
How does cisplatin affect the DNA helix?
A
The two chlorine atoms are replaced by guanine bases
This distorts the shape of the cancer DNA
As DNA is responsible for replication, this stops reproduction
3
Q
How does cisplatin bond to guanine?
A
Nitrogen atoms of guanine have lone pairs which form dative covalent bonds with platinum
4
Q
What kind of reaction is the bonding between cisplatin and DNA?
A
A ligand substitution reaction because the chloride ions are replaced by the guanine, due to being better ligands
5
Q
What is the structure of cisplatin?
A
See card
