3- Schizophrenia History, Diagnosis and Epidemiology Flashcards

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1
Q

Who was the first person to attempt to define schizophrenia?

A

Kraepelin

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2
Q

How did Kraepelin define schizophrenia?

A

As the ‘dementia paradox’

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3
Q

Who coined the term schizophrenia?

A

Bleuler

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3
Q

What was the Kraepelinian dichotomy?

A

Distinction made between the dementia paradox (schizophrenia) from manic-depressive psychosis (bipolar disorder)

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3
Q

What did Bleuler’s schizophrenia definition describe?

A

The fragmented thinking of people with the disorder

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4
Q

What is a common misconception of schizophrenia?

A

It conveys a split or multiple personality

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5
Q

What 6 negative outcomes is schizophrenia associated with?

A
  1. Very high distress levels
  2. High suicide rate
  3. High unemployment
  4. Reduced average life expectancy
  5. Economical cost of £11.8 billion per year
  6. No uniformly negative outcomes
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6
Q

How is diagnosis made from the DSM-5?

A

Made based on someone’s history and mental state

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7
Q

How is a diagnosis made?

A

At least 2 characteristic symptoms must be present for a significant amount of time during a 1 month period

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8
Q

Is there a single unifying symptom for a diagnosis?

A

No

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9
Q

What are positive symptoms?

A

Symptoms happening in addition to typical experience

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10
Q

What are negative symptoms?

A

Some aspect of human thought/function removed

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11
Q

What are cognitive symptoms?

A

Symptoms related to cognitive functions

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12
Q

When is it most common for schizophrenia onset to begin?

A

Between ages 15-25

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13
Q

When is there another peak in onsets (for women but not for men)?

A

Between ages 45-49

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14
Q

When is the onset of schizophrenia very uncommon?

A

In childhood

15
Q

What term describes the many types of schizophrenia?

A

Umbrella

16
Q

4 factors that differential diagnosis must account for?

A
  1. Length of illness
  2. Pattern and nature of associated substance use
  3. Co-occurrence of mania and depression
  4. Presence of other illnesses
17
Q

3 arguments for the schizophrenia definition being too wide

A
  1. No unifying symptom
  2. Very heterogenous
  3. Many different causal mechanisms
18
Q

2 arguments for schizophrenia definition being too narrow

A
  1. Genetic overlap between schizophrenia and other psychiatric conditions
  2. Often receive multiple diagnoses