24) Lethality, lethal gene mutations in breeding Flashcards

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1
Q

All individuals with lethal gene mutations will…

A

Die before sexual maturity

  • Embryonic fatality
  • Fetal fatality
  • Prenatal fatality
  • Postnatal fatality
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2
Q

Most lethal genes are…

A

Recessive

  • Lethal in homozygotes
  • Heterozygotes are carriers
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3
Q

Dominant mutation alleles…

A
  • Rare
  • Heterozygotes are carriers only
  • Homozygotes will die
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4
Q

Death in homozygotes leads to…

A
  • Segregation ratio in F2 generation of 2:1
  • Instead of 1:2:1
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5
Q

Sublethal condition

A

More than 50% die

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6
Q

Sub-vital condition

A
  • More than 50% will live
  • They will have defects
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7
Q

Dominant lethal genes

A
  • Yellow mutation in field mice
  • Manx factor in cats
  • Merle colour in dogs
  • Silver fox platinum colour mutant
  • Silver fox white face mutant
  • Lethal white overo foals of paint horses
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8
Q

Yellow mutation in field mice

A
  • Embryonic lethality
  • YY lethal
  • Yy yellow coat
  • 2:1 ratio
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9
Q

Manx factor in cats

A

MXmx lethal (taillessness)

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10
Q

Merle colour in dogs

A
  • MM subvital
  • Mm merle colour
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11
Q
  • Silver fox white face mutant
  • Silver fox platinum colour mutant
A

Both embryonic lethality

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