23. Individual proteins – proteins of the acute phase

Question 1

What are Acute Phase Proteins, APP?

Answer 1

Class of Proteins

INCREASED / DECREASED Plasma Concentrations

Due to Inflammation = Acute Phase Reaction

Question 2

What are Proteins with INCREASED Plasma Concentrations Called?

Answer 2

POSITIVE Acute Phase Proteins

Question 3

What are Proteins with DECREASED Plasma Concentrations Called?

Answer 3

NEGATIVE Acute Phase Proteins

Question 4

What are Examples of POSITIVE Acute Phase Proteins?

Answer 4

C-Reactive Protein

Antitrypsin

Fibrinogen

Celluloplasmin

Serum Amyloid A

Haptoglobin

Question 5

What are Examples of NEGATIVE Acute Phase Proteins?

Answer 5

Pre-Albumin

Albumin

Transferrin

Question 6

What is C-Reactive Protein, CRP?

Answer 6

Protein in Blood

Where Levels RISE

IN RESPONSE to Inflammation

Question 7

What Causes INCREASED CRP?

Answer 7

INCREASED Plasma Conc of IL-6

Produced by Macrophages + Adipocytes

Question 8

What does CRP Bind to, in Microbes?

Answer 8

Phosphocholine

Question 9

What is the C-Reactive Protein Test?

Answer 9

Measure CRP Levels

TO ASSESS Acute Inflammation

Question 10

What is the Role of C-Reactive Protein?

Answer 10

Innate Immunity

Early Defence System Against Infections

Question 11

What is CRP a Marker for?

Answer 11

Inflammation + Infection

Rough Proxy for Heart Disease Risk

Question 12

What Specimen if Required for CRP Test?

Answer 12

Serum

Question 13

What are the Analytical Methods of CRP Investigation?

Answer 13

ELISA

Immunoturbidimetry

Rapid Immunodiffusion

Visual Agglutination

High-Sensitivity CRP Test

Question 14

What is a High-Sensitivity CRP Test?

Answer 14

Measures LOW Levels of CRP

Using Laser Nephelometry

Question 15

What are the Reference Ranges of C-Reactive Protein?

Answer 15

UP-TO 3 mg / L

Question 16

What are the Indications of CRP Levels?

Answer 16

Normally = NO CRP in Blood

HIGH Levels = Acute Inflammation; Rheumatic Diseases