2.1 Molecules to Metabolism Flashcards
Define molecular biology
A field of study that investigates biological activity on a molecular level
Define an organic compound
Contains carbon and is in living things
except carbides, carbonate, oxides of carbon and cyanides
What is the common ratio for carbohydrates?
(CH2O)n
Which is the most abundant hydrocarbon?
Carbohydrates
What are the functions of carbohydrates?
Short-term energy storage
Important recognition molecules
As a structural components (DNA/RNA)
What are properties of lipids?
Non-polar
Hydrophobic
Why are lipids good for storage of energy?
They are hydrophobic and thus do not absorb water
What are the functions of lipids?
Part of a cell membrane
Long-term storage molecule
Signalling molecule (steroids)
What are the building blocks for DNA and RNA?
Nucleic acids
What is the function of DNA?
A master code for protein assembly
What is the function of RNA?
Plays an active role in the manufacturing of proteins
What are the functions of proteins?
Involved in catalysis
Structural molecules
Cellular signalling
What is the polymer of lipids?
Triglyceride
What is the monomer of lipids?
Fatty acids
What is the monomer of carbohydrates?
Monosaccharide
What are the 2 main types of sugars?
Pentose and Hexose
What type of sugar is glucose?
Hexose
What type of sugar is ribose?
Pentose
Name 2 types of glucose?
a - D glucose
B - D glucose
Describe the structure of an a - D glucose
The 1 C has an OH facing downwards (all OH face down)
Describe the structure of a B - D glucose
The 1 C has an OH facing upwards
Describe the structure of lipids
There is no set structure as it varies. However, many do contain fatty acid chains as a part of this overall structure.
Describe the structure of a fatty acid
Has a C=O-OH end (carboxyl group) and the rest is a simple alkane hydrocarbon structure
What do we call an amino acid polymer?
Polypeptide
Describe an amino acid
Has an amine group (N-H2) and a carboxyl group (C=O-OH) on ether end coming off a central carbon. This carbon also has a H molecule and a variable R molecule bonded to it.
What is the monomer of nucleic acid?
Nucleotide
Describe a generalised structure of a generalised nucleotide
A phosphate group, bonded to a ribose sugar, bonded to a nitrogenous base
What do we call a polymer made of sugars?
Polysaccharide
Name 3 polymers of glucose
Glycogen
Cellulose
Starch
What are the 3 categories of lipids?
Simple (neutral) lipids
Compound lipids
Derived lipids
What are simple (neutral) lipids?
Esters of fatty acids and alcohol (e.g. triglycerides and waxes)
What are compound lipids?
Esters of fatty acids, alcohol and additional groups (e.g. phospholipids and glycolipids)
What are derived proteins?
Substances derived from simple or compound lipids (e.g. steroids and carotenoids)
Describe the structure of a triglyceride
A glycerol molecule with 3 fatty acids attached
Describe the structure of a phospholipid
A glycerol with 2 fatty acids attached and one phosphate group
Describe the rough structure of a steroid
Made of fused hydrocarbon rings
What type of bond holds amino acids together?
Peptide bonds between amine and carboxyl groups of adjacent amino acids
How do dipeptides form?
Amino acids undergo condensation
What is vitalism
A doctrine that dictated that organic molecules could only be synthesised by living systems
When and how was vitalism disproved?
1828 - Fredrick Woehler heated inorganic salt and produced urea
Define metabolism
Describes the totality of chemical processes that occur within an organism to maintain life
What are the functions of metabolic reactions?
Provide energy for cellular purposes
Enable the synthesis of new materials within the cell
Define an anabolic reaction?
Describes the set of metabolic reactions that build up the complex molecules from simpler ones
Via what mechanism do anabolic reactions usually occur?
Condensation reactions
What joins monosaccharides?
Glyosidic linkages
What joins amino acids?
Peptide bonds
What joins glycerol and fatty acids?
Ester linkages
What does 1 glycerol and 3 fatty acids form?
A triglyceride
What joins nucleotides?
Phosphodiester bond
What is characteristic about a condensation reaction?
Water is released
Define catabolic reactions
Describes the set of metabolic reactions that break complex molecules down into simpler molecules
Via what mechanism do catabolic reactions usually occur?
Hydrolysis reaction