11.3 Kidney (HL) Flashcards

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1
Q

What is the excretory system in insects?

A

Malpighian tubules

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2
Q

How do Malpighian tubules work?

A

Directly branches of the intestinal tract and uptakes nitrogenous waste which is combined later with digested food and excreted via the anus

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3
Q

Describe the structure of the kidney

A

Oxygenated blood brought by the renal artery and deoxygenated removed via the renal vein
The ureter leads into the renal pelvis which branches into medulla surrounded by a cortex

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4
Q

What molecule in the kidney filter blood?

A

Nephrons

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5
Q

What do nephrons produce?

A

Urine

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6
Q

How will blood in the renal vein differ from that in the renal artery?

A

Less urea
Less water and solutes
Less glucose and O2
More CO2

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7
Q

Describe the components of a nephron

A

Bowman’s capsule
Proximal convoluted tubule
Loop of Henle
Distal convoluted tubule

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8
Q

What is the function of the Bowman’s capsule (kidney)?

A

First part of the nephron where blood is initially filtered to form filtrate

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9
Q

What is the function of the proximal convoluted tubule (kidney)?

A

Folded structure connected to the Bowman’s capsule where selective reabsorption occurs

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10
Q

What is the function of the loop of Henle (kidney)?

A

Selectively permeable loop that descends into the medulla and establishes a salt gradient

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11
Q

What is the function of the Distal convoluted tubule (kidney)?

A

Folded structure connected to the loop of Henle where further selective reabsorption occurs

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12
Q

What are the functions of nephrons?

A

Ultrafiltration
Selective reabsorption
Osmoregularion

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13
Q

Where in the nephron does ultrafiltration occur?

A

The glomerulus at the Bowman’s capsule

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14
Q

Where in the nephron does selective reabsorption happen?

A

In the convuluted tubules (proximal and distal)

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15
Q

Where in the nephron does osmoregulation happen?

A

In the loop of Henle a salt gradient draws water out of the collective duct

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16
Q

Describe the glomerulus

A

A knot-like capillary tuft encapsulated by the Bowman’s capsule and comprised of surface cells called podocytes
Between the podocytes and glomerulus is a basement membrane which filters blood

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17
Q

Describe the structure of podocytes

A

Cells with cellular extensions (pedicles) that wrap around the blood vessel of the glomerulus

18
Q

Describe the process of blood filtration in nephrons

A

Blood is filtered by a mesh called the basement membrane
The glomerular blood vessels are fenestrated to allow blood to flow freely

19
Q

How is the basement membrane selective?

A

It is size-selective

20
Q

What cannot be found in the filtrate of the nephron?

A

Blood cells, platelets and plasma proteins

21
Q

How does hydrostatic pressure aid in ultrafiltration?

A

Blood is forced at high pressure against the basement membrane

22
Q

How is high hydrostatic pressure achieved in the glomerulus?

A

Wider afferent arteriole that leads into a narrow efferent arteriole

23
Q

Describe selective reabsorption (kidney)

A

Reuptake of useful substances mostly in the proximal convoluted tubule

24
Q

What feature of the proximal convoluted tubules makes it good for reabsorption?

A

Microvilli with tight junctions and many mitochondria

25
Q

What is reabsorbed into the blood stream?

A

Glucose, amino acids, vitamins, hormones, (~80%) mineral ions and water

26
Q

How are mineral ions reabsorbed by the proximal convoluted tubule?

A

Actively via protein pumps

27
Q

How are vitamins reabsorbed by the proximal convoluted tubule?

A

Actively via carrier proteins

28
Q

How are glucose and amino acids reabsorbed by the proximal convoluted tubule?

A

Co-transported across the apical membrane with sodium

29
Q

How is water reabsorbed by the proximal convoluted tubule?

A

Follows the movement of mineral ions passively via osmosis

30
Q

Which two key features in the kidney are involved in osmoregulation?

A

Loop of Henle
ADH

31
Q

Where is the salt gradient in the kidney?

A

In the medulla in the loop of Henle (nephrons)

32
Q

What is the descending limb of the loop of Henle permeable to?

A

Water but not salt

33
Q

What is the ascending limb of the loop of Henle permeable to?

A

Salt but not water

34
Q

How does the salt gradient change throughout the loop of Henle?

A

As the loop descends to the medulla it becomes more salty and hypertonic

35
Q

In which way does the vasa recta blood network flow and what does this cause?

A

In the opposite direction to the loop of Henle which means salts released from the ascending limb are drawn down into the medulla further establishing the gradient

36
Q

What effect does ADH have?

A

Increases water reabsorption by the kidney

37
Q

How does ADH increase water absorption?

A

It increases the permeability of the collecting duct to water and so less water remains in the filtrate

38
Q

What effect does dehydration have on blood pressure?

A

Decreases

39
Q

What effect does overhydration have on blood pressure?

A

Increases

40
Q

What urinary analysis could signal of disease?

A

Glucose (diabetes)
Proteins (may indicate disease or hormonal conditions)
Blood cells (variety of diseases including cancer)
Drugs/ toxins (PEDs)

41
Q

Describe haemodialysis

A

Blood is removed and pumped through a dialyser which restricts the passage of certain molecules and produces fresh dialysis fluids and removes waste

42
Q

What is the best treatment for long-term kidney faliure?

A

Kidney transplant