2 - Repro - Origin of the Sexes 2 Flashcards

1
Q

At approx. which month of development do the testes reach the scrotum?

A

~ 9th month

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2
Q

What structure passes through the inguinal canal in females?

A

Round ligament of the uterus

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3
Q

Name the ligament which connects the ovary to the uterus:

A

Ovarian ligament

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4
Q

Name the ligament which connects the uterus to the labia majora:

A

Round ligament of the uterus

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5
Q

Name the syndrome caused by a (47, XXY) chromosome defect:

A

Klinefelter syndrome

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6
Q

If an embryo has no gonads due to a defect, would it develop male or female internal genitalia?

A

Female internal genitalia

- Mullerian ducts form, and Wolffian ducts regress due to lack of androgens

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7
Q

Is someone with Klinefelter syndrome a male or female?

A

Male, with small/undescended testes

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8
Q

Why may someone with Klinefelter syndrome have delayed/incomplete puberty?

A

Less than usual amount of testosterone produced

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9
Q

Name the syndrome caused by a (45, XO) chromosome defect:

A

Turner’s syndrome

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10
Q

Is someone with Turner’s syndrome a male or female?

A

Female, with no ovaries

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11
Q

When is Turner’s syndrome usually diagnosed? Why?

A
  • At age when puberty usually occurs

- Girls with Turner’s syndrome do not go through puberty, due to lack of ovaries

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12
Q

If someone has a (46, XY) karyotype but the fetal genitalia is insensitive to testosterone and DHT, will they be born phenotypically female or male?

A

Female

- Have undescended testes

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13
Q

If someone has a (46, XX) karyotype but have excessive androgen secretion from adrenal glands, will they be born phenotypically female or male?

A

Male

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14
Q

List the reproductive hormones secreted by the hypothalamus:

A
  • Peptide releasing factors
  • GnRH
  • PRH
  • PIH (Dopamine)
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15
Q

List the reproductive hormone released by the posterior pituitary:

A

Oxytocin

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16
Q

List the reproductive hormones released by the anterior pituitary:

A
  • FSH
  • LH
  • Prolactin
17
Q

List the reproductive hormones released by gonads:

A
  • Testosterone
  • Oestrogens: Oestradiol, Oestrone, Oestriol
  • Progesterone
  • Inhibin
18
Q

List the main reproductive hormones released by the placenta:

A
  • hCG
  • hPL
  • Oestrogens: Oestradiol, Oestrone, Oestriol
  • Progesterone
19
Q

Which part of the pituitary gland is formed from the forebrain, and so called the ‘neurohypophysis’?

A

Posterior pituitary

20
Q

Which part of the pituitary gland is formed from an evagination of the developing mouth ‘Rathke’s pouch’, and called the adenohypophysis?

A

Anterior pituitary

21
Q

Approx how many seminiferous tubules are present in each testes?

A

~ 250 - 750 per testes

22
Q

Name the cells found in the seminiferous tubules:

A
  • Spermatocytes
  • Spermatids
  • Sertoli cells
  • Myofibroblasts
  • Leydig cells
23
Q

What is the importance of the blood-testes barrier (tight junctions between sertoli cells in seminiferous tubules)?

A

The sperm are genetically different to the father’s cells, so must be kept apart otherwise high risk of autoimmune attack

24
Q

Name the cells lining the rete testis and efferent ductules:

A

1) Columnar ciliated cells

2) Cuboidal cells (remove fluid and concentrate sperm)

25
Q

What is the function of the cuboidal cells lining the rete testis and efferent ductules?

A

Absorb fluid, concentrating sperm

26
Q

In what stage of meiosis does crossing over occur?

A

Prophase I

27
Q

In what stage of meiosis does independent assortment take place?

A

Metaphase I

28
Q

What is the main difference between meiosis in males and females?

A
Males = 1 germ cell forms 4 spermatogonia
Females = 1 germ cell forms 1 oocyte
29
Q

How many chromosomes is present in a gamete?

A

23 chromosomes

30
Q

Approx. how many sperm are formed per day?

A

~ 200 million per day