סכיזורפניה 2 Flashcards

1
Q

Question

A

Answer

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2
Q

Who are the two major figures in psychiatry who studied schizophrenia?

A

Emil Kraeplin and Eugene bleuler.

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3
Q

Who used the term demencia praecox for schizophrenia?

A

Benedict Morel in French- demence precoce, and then kraeplin translated it to dementia precox, A term that emphasized the change in cognition and early onset of the disorder.

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4
Q

Who coined the term schizophrenia?

A

Eugene bleuler. He chose the term to express the presence of schisms among thoughts emotion and behavior in schizophrenics. Unlike kraeplin, schizophrenia need not have a deteriorating course according to Eugene.

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5
Q

What are the four A’s of schizophrenia and who coined them?

A

Associations, affect, autism, ambivalence. Secondary symptoms include hallucinations and delusions according to Eugene bleuler.

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6
Q

What was Ernest Kretzschmar’s theory about schizophrenia and body type?

A

Schizophrenia occurred more often among persons with asthenic, athletic or dysplastic body types.

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7
Q

According to Kurt Schneider can schizophrenia be diagnosed in patients without first rink schneiderian symptoms?

A

Even though clinicians frequently ignore his warnings , Schneider emphasize that at patients who showed no first rank symptoms, the disorder could be diagnosed exclusively on the basis of second rank symptoms and otherwise typical clinical appearance.

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8
Q

What are Kurt schneider’s first and second rank symptoms?

A

First rank: delusion of control, thought broadcasting, thought withdrawal, thought insertion, hearing one’s thoughts spoken aloud, auditory hallucinations that comment on one’s behavior, and auditory hallucinations in which two voices carry on a conversation. Some schizophrenic patients never exhibit first-rank symptoms or only experience them in some psychotic episodes. They may also occur in mania. Second-rank symptoms are common symptoms of schizophrenia but also often occur in other forms of mental illness. They include delusions of reference, paranoid and persecutory delusions, and second-person auditory hallucinations.

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9
Q

Who was karl Jaspers?

A

An existential psychoanalyst. He tried to understand the meaning of signs and symptoms in schizophrenia like delusions and hallucinations.

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10
Q

Who is adolf Meyer?

A

The founder of psychobiology. He saw schizophrenia as a reaction to stress. In the 1950s he coined the term “schizophrenic reaction” which was dropped in later DSM editions.

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11
Q

What is the lifetime prevalence of schizophrenia?

A

Between 0.6 to 1.9% According to the epidemiologic catchment area study sponsored by the NIH. About 0.05% are treated for schizophrenia per year. About half of schizophrenics obtain treatment.

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12
Q

What Is the difference between male and female in schizophrenia?

A

The prevalence is the same. They differ in onset and course. Onset is earlier in men. Peak onset for men is 10 to 25. Peak onset for women is 25 to 35. Women have A bimodal age distribution. 3 to 10% of women present after the age of 40( a second peak).Men have more negative symptoms. Women are more likely to have better social functioning before disease onset than men. Outcome for female schizophrenics is better then male.

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13
Q

When is the typical age that 90% of schizophrenics present their illness?

A

15-55

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14
Q

What is late onset schizophrenia?

A

After 45 years old.

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15
Q

What is the risk of a 1st° relative of a patient with schizophrenia to develop the disease?

A

10 times the general population.

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16
Q

What is the fertility rate of persons with schizophrenia?

A

Close to the general population.

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17
Q

What is the mortality rate among schizophrenics compared to the general population?

A

It is higher- from accidents and natural causes. Studies have shown that up to 80% of schizophrenics have concurrent medical illnesses and up to 50% may be undiagnosed.

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18
Q

During which season are schizophrenics usually born? With what infection is schizophrenia associated?

A

1.Winter and early spring. Northern hemisphere January to April and southern hemisphere July to September.2. Particularly influenza.

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19
Q

Which factors did studies show increase risk for schizophrenia?

A

1)Gestational and birth complications. 2)Exposure to influenza epidemics(specially during second trimester). 3)Maternal starvation during pregnancy. 4)Rhesus factor incompatibility. 5)an excess of winter births.

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20
Q

What is the lifetime prevalence of any drug abuse other than tobacco in schizophrenics?

A

50%

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21
Q

True or false : for all drugs of abuse, abuse is associated with poorer function.

A

True. For drugs other than tobacco.

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22
Q

What is the lifetime prevalence of alcohol in schizophrenics?

A

40%

23
Q

How does alcohol abuse affect schizophrenics?

A

It increases hospitalization and may increase psychotic symptoms.

24
Q

What is the risk of schizophrenia high level cannabis users?

A

Sixfold.

25
Q

What is the connection between nicotine and schizophrenia?

A

1) up to 90% of schizophrenics depend on nicotine.2) nicotine decreases blood concentrations of some antipsychotics.3) A specific polymorphism in the nicotinic receptor has been linked to genetic risk for schizophrenia.4) nicotine administration improves some cognitive impairments and parkinsonism in schizophrenia.5)nicotine may decrease positive symptoms such as hallucinations, Through nicotine receptors that reduce perception of outside stimuli- Especially Noise.

26
Q

How is population density connected with schizophrenia?

A

Increased population density especially more than 1 million people increases likelihood of schizophrenia. Correlation lower with smaller . With 10,000 and less- no correlationIncidence of schizophrenia increases in urban compared to rulal communities ( twice)

27
Q

What is the percentage of schizophrenics among the homeless is in the United States?

A

Between 15 to 45%.

28
Q

What is the probability of readmission with in two years after discharge from first hospitalization?

A

40 to 60%.

29
Q

What percentage do schizophrenics occupy of mental hospital beds?

A

50%.

30
Q

What percentage of psychiatric patients who received treatment are schizophrenics?

A

16%.

31
Q

What is the concordance rate for schizophrenia among monozygotic twins?

A

50%.

32
Q

What is the probability of schizophrenia among the following. One parent with schizophrenia one sibling with schizophrenia Dizygotic twin with schizophrenia two parents with schizophrenia monozygotic twin with schizophrenia

A

One parent with schizophrenia 12%one sibling with schizophrenia 8%Dizygotic twin with schizophrenia 12%two parents with schizophrenia 40% monozygotic twin with schizophrenia 47%

33
Q

Is there a connection between parents age and development of schizophrenia?

A

Some data indicate that age of father correlates with development of schizophrenia.

34
Q

Which linkage sites are associated with schizophrenia?

A

1q, 5Q. 6P. 6Q. 8P, 10p, 13q,15 q ,22q

35
Q

What are the candidate genes best correlated with schizophrenia?

A

Alpha7 nicotinic receptor. Disc 1GRM3. COMT. Nrg 1RGS 4G 72. Dystrobrevin (DTNBP1) - negative symptomsNeureglin1- negative symptoms

36
Q

Which tracts are involved in the dopaminergic pathophysiology of schizophrenia?

A

Mesocortical and mesolimbic tracts.Pet studies showed increase D2 receptors in the caudate nucleus in drug-free schizophrenics. And increase of dopamine in the amygdala. Decreased density of dopamine transporter. Increased D4 receptors in entorhinal cortex.

37
Q

Other than dopamine , which other neurotransmitters are associated with schizophrenia?

A

Excess serotonin both positive and negative symptoms. Norepinephrine - anhedonia. GABA- some have loss in hippocampus . regulatory on dopamine activity. Neuropeptides substance P and neurotensin- influence catecholamine and indolamine neurotransmitters.Glutamate -PCP antagonizes glutamate .acute PCP ingestion produces an acute schizophrenia like syndrome.Acetylcholine and nicotine-decreased muscarinic and nicotinic receptors in the caudate-putamen, hippocampus and regions in the prefrontal cortex. involved in cognition.

38
Q

Which theory is related to the fact that schizophrenia usually develops during adolescence?

A

Excessive pruning of synapses during this phase of development.

39
Q

What is found in the CT of schizophrenics?

A

1)Lateral and third ventricular enlargement. 2)Some reduction in cortical volume. 3)Reduced volumes of cortical gray matter during earliest stages of disease. It is not known yet if progressive or static.

40
Q

What theory regarding neurodevelopment is associated schizophrenia?

A

reduced symmetry including temporal, frontal , and occipital lobe. Disruption of brain lateralization during neurodevelopment.

41
Q

How is the limbic system connected to schizophrenia?

A

Studies have shown a decrease in size of amygdala , hippocampus and parahippocampal gyrus. Hippocampus is not only smaller but functionally abnormal in glutamate transmission. Disorganization of neurons in tissue section.

42
Q

What is found in the prefrontal cortex of schizophrenics?

A

Anatomical and functional abnormalities. Several symptoms mimic frontal lobe syndrome.

43
Q

How is the thalamus compared to the general population in schizophrenics?

A

Shrunk. Total number of cells reduced by 30 to 45%. Not due to antipsychotic drugs.In particular subneclei. the medial dorsal nucleus of thalamus which has reciprocal connections with the prefrontal cortex.

44
Q

Where in the basal ganglia do studies show increased D2 receptors? What is the increase related to in part?

A

Caudate. Putamen. Nucleus accumbans. May be related to neuroleptics.

45
Q

which circuit is related to positive symptoms of schizophrenia?

A

Dysfunction of the anterior cingulate basal ganglia thalamocortical circuit.

46
Q

Which circuit is related to the negative symptoms of schizophrenia?

A

Dysfunction of the dorsolateral prefrontal cortex.

47
Q

What is the neural basis for cognitive dysfunctions in patients with schizophrenia?

A

Impaired working memory performance, disrupted prefrontal neuronal integrity, altered prefrontal cingulate and inferior parietal cortex, altered hippocampal blood flow. Especially for auditory hallucinations.

48
Q

Which molecules are found lower/higher in schizophrenics -using magnetic resonance spectroscopy?

A

Lower levels of phosphomonoesters and inorganic phosphate .higher levels of phosphodiester. Lower levels of n- acetyl aspartate in hippocampus and frontal lobe.

49
Q

Which EEG abnormalities were found in schizophrenics?

A

Increased sensitivity to activation procedures. Decreased alpha activity. Increased theta and Delta activity. More epileptiform activity than usual. More left-sided abnormalities. Inability to filter irrelevant sounds- extreme sensitivity to background noise. This makes concentration difficult and may be a factor in production of auditory hallucinations.

50
Q

In which disorder may we see schizophrenia like psychosis?

A

Complex partial seizures with a focus in left-sided medial temporal lesion. early onset of seizures. First rank schneiderian symptoms.

51
Q

Which abnormalities in evoked potential Have been reported in schizophrenics?

A

Smaller p300. Also in children to schizophrenic parents.Abnormal n100 and contingent negative variation.

52
Q

What is the eye movement dysfunction seen in schizophrenics and in what percentage ?

A

Inability to follow moving visual target accurately, disinhibition of saccadic Eye movements. Seen in first-degree relatives.Percentages: 50-85% of schizophrenics, 25% of psychiatric patients w.o. Schizophrenia, 10% in non psychiatrically ill.

53
Q

Which psycho narrow in psychoneuromunological abnormalities have been associated with schizophrenia?

A

Decreased T cell Iinterleukin 2 productionReduced number and responsiveness of peripheral lymphocytes. Abnormal cellular and humeral reactivity to neurons. Presence of brain directed(. Anti brain) antibodies.

54
Q

Which neuroendocrine differences were reported in schizophrenics?

A

1)Abnormal dexamethasone suppression test. Correlation between nonsuppression and poorer outcome.2) decreased LH and FSH.3) Blunted release of prolactin and GH on GnRH or TR H stimulation.4) blunted release of GH on apomorphine stimulation.