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Transplantatie > 18/12 maligniteiten > Flashcards

18/12 maligniteiten Flashcards

1
Q

factoren van invloed ontwikkelen kanker na transplantatie

A
  1. oorzaak nierfalen
  2. tijd na transplantatie
  3. leeftijd van ontvanger
    4.intensiteit en duur van immunsuppressiva
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2
Q

Virussen met oncogene eigenschappen

A
  • Hepatits B & C
  • Humaan T-lymphotropic virus (HTLV)
    -humaan papillomaviruses (HPV) type 16 en 18
  • Humaan herpesvirus
  • Merkel cell polyomavirus
    -Eppstein Barr virus
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3
Q

Hoe werkt het epstein barr virus

A

proliferatie van B-lymfocyten
bestrijding door cytotoxische T-lymfocyten

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4
Q

Wat is PTLD

A

posttransplantation lymfoproliferatieve disease
lymfoom doordat prolifererende B-lymfocyten niet meer in toom worden gehouden door T-lymfocyten
1-10% kans

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5
Q

Behandeling PTLD

A
  • reductie/ staken van immunosuppressiva
  • anti-b cel (rituximab)
  • chemotherapie
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6
Q

Meest voorkomende kanker na transplantatie

A

PCC
- zonlicht expositie grootste risicofactor

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7
Q

preventie kanker na transplantatie

A

-zonnebrand
-screening

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Transplantatie (25 decks)

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