Yonit Obesity Pharmocology Flashcards
What are the definition for metabolic syndrome
Three out of five from the following abdominal obesity level of triglycerides low HDL high blood pressure high glucose
How we measure BMI
Weight/height times2
What is the DEXA method for measuring obesity
Method where the density of the bone is measured
How do appetite stimulating neurons are called
AgRP/NPY
What is leptin resistance
when brain stops acknowledging the hormone’s signal - you have enough of the hormone available and energy stored,but your brain does not recognize it and thinks you’re still hungry
Where are genes that are related to deficiency of leptin are located in respect to the presence of leptin on that DNA
Downstream
In less than how much weight loss we stop the pharmacology treatment
Less than 5% over 12 months
How does the orlistat medication works
Inhibit lipase In the intestines
Which side effects Orlistat has
mostly as the digestive system inhibits absorption of fat-soluble vitamins From google - Gas (flatulence) with discharge. Fatty/oily stools Increased defecation Fecal incontinence/inability to control bowel movements Urgent bowel movements Loose stools Clay-colored stools Diarrhea
How orlistat medication affect development of diabetes
Inhibits development of new diabetes
How phentermine helps to decreaes weight gain
Suppresses hunger by release of norepinephrine and activates POMC
How topiramate helps weight less
Activates GABA which inhibits AgRP/NPY neurons in the hypothalamus
Does the combination of phentermine and topiramate is dangerous
It is, but effective
How we should treat a patient that gets Orlistat
Subscribe them vitamins that are soluble in fat
What is glp1
Hormone that increase secretion of insulin
Liraglutide is an analog to which hormone
GLP-1
What is considered the most effective drug for weight loss
Combination of Phanteramine and topiromate
Semaglutide is analog of which hormone
Glp1
How glucagon has the potential to be a treatment against obesity
Increases level of energy expenditure
Which Hormonal combination can be successful in weight lowering
GLP 1 and glucagone
Which combination of hormones can be beneficial for weight loss beside glucagon with GLP1
Glp1 and gip
Where incertines are active
Nervous system and digestive system
How peptide YY helps to weight loss
reduce hunger by inhibition of AgRP/NPY
בבני אדם הפפטיד נמצא ברמות גבוהות ברוק, וכנראה שמדובר בחלק עיקרי
בפעולה של הפפטיד
How analog of amylin can help weight loss
with secretion of insulin - Increases satiety, decreasing caloric intake
What is usually the complexity with leptin
Problem with the leptin receptors and not the lack of the hormone
מה תפקידה של SGLT2?
אחראי על הספיגה מחדש של כ-90% מהגלוקוז אשר עובר בלולאה הפרוקסימלית בגלומרולוס (Glomerulus)
How inhibition of sglt2 helps lower glucose 
It increases urinary glucose excretion
How inhibition of sglt1 helps lowering glucose
Inhibit absorption of intestinal sugar
What is the name of the drug that works as an inhibitor of the sodium glucose transporter
Canagliflozin
Does FXR and GPR131 helps weight loss
Yes
Why CB1R blockers were reduced from market
Caused depression
In which way the psychiatric effect of CB1R blockers been tried to avoid
Avoid crossing BBB
Does hypothalamus is after bbb
No
how SGLT2 reduces glucose?
inhibit the reabsorption of the glucose in the glomerulus
