Yonit Obesity Pharmocology Flashcards

(34 cards)

1
Q

What are the definition for metabolic syndrome

A
Three out of five from the following
abdominal obesity
level of triglycerides
low HDL 
high blood pressure 
high glucose
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How we measure BMI

A

Weight/height times2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the DEXA method for measuring obesity

A

Method where the density of the bone is measured

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How do appetite stimulating neurons are called

A

AgRP/NPY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is leptin resistance

A

when brain stops acknowledging the hormone’s signal - you have enough of the hormone available and energy stored,but your brain does not recognize it and thinks you’re still hungry

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Where are genes that are related to deficiency of leptin are located in respect to the presence of leptin on that DNA

A

Downstream

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

In less than how much weight loss we stop the pharmacology treatment

A

Less than 5% over 12 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How does the orlistat medication works

A

Inhibit lipase In the intestines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which side effects Orlistat has

A
mostly as the digestive system
inhibits absorption of fat-soluble vitamins
From google - 
Gas (flatulence) with discharge.
Fatty/oily stools
Increased defecation
Fecal incontinence/inability to control bowel movements
Urgent bowel movements
Loose stools
Clay-colored stools
Diarrhea
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How orlistat medication affect development of diabetes

A

Inhibits development of new diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How phentermine helps to decreaes weight gain

A

Suppresses hunger by release of norepinephrine and activates POMC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How topiramate helps weight less

A

Activates GABA which inhibits AgRP/NPY neurons in the hypothalamus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Does the combination of phentermine and topiramate is dangerous

A

It is, but effective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How we should treat a patient that gets Orlistat

A

Subscribe them vitamins that are soluble in fat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is glp1

A

Hormone that increase secretion of insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Liraglutide is an analog to which hormone

17
Q

What is considered the most effective drug for weight loss

A

Combination of Phanteramine and topiromate

18
Q

Semaglutide is analog of which hormone

19
Q

How glucagon has the potential to be a treatment against obesity

A

Increases level of energy expenditure

20
Q

Which Hormonal combination can be successful in weight lowering

A

GLP 1 and glucagone

21
Q

Which combination of hormones can be beneficial for weight loss beside glucagon with GLP1

22
Q

Where incertines are active

A

Nervous system and digestive system

23
Q

How peptide YY helps to weight loss

A

reduce hunger by inhibition of AgRP/NPY
בבני אדם הפפטיד נמצא ברמות גבוהות ברוק, וכנראה שמדובר בחלק עיקרי
בפעולה של הפפטיד

24
Q

How analog of amylin can help weight loss

A

with secretion of insulin - Increases satiety, decreasing caloric intake

25
What is usually the complexity with leptin
Problem with the leptin receptors and not the lack of the hormone
26
מה תפקידה של SGLT2?
אחראי על הספיגה מחדש של כ-90% מהגלוקוז אשר עובר בלולאה הפרוקסימלית בגלומרולוס (Glomerulus)
27
How inhibition of sglt2 helps lower glucose 
It increases urinary glucose excretion
28
How inhibition of sglt1 helps lowering glucose
Inhibit absorption of intestinal sugar
29
What is the name of the drug that works as an inhibitor of the sodium glucose transporter
Canagliflozin
30
Does FXR and GPR131 helps weight loss
Yes
31
Why CB1R blockers were reduced from market
Caused depression
32
In which way the psychiatric effect of CB1R blockers been tried to avoid
Avoid crossing BBB
33
Does hypothalamus is after bbb
No
34
how SGLT2 reduces glucose?
inhibit the reabsorption of the glucose in the glomerulus