Yonit Obesity Pharmocology

Question 1

What are the definition for metabolic syndrome

Answer 1

Three out of five from the following
abdominal obesity
level of triglycerides
low HDL 
high blood pressure 
high glucose

Question 2

How we measure BMI

Answer 2

Weight/height times2

Question 3

What is the DEXA method for measuring obesity

Answer 3

Method where the density of the bone is measured

Question 4

How do appetite stimulating neurons are called

Answer 4

AgRP/NPY

Question 5

What is leptin resistance

Answer 5

when brain stops acknowledging the hormone’s signal - you have enough of the hormone available and energy stored,but your brain does not recognize it and thinks you’re still hungry

Question 6

Where are genes that are related to deficiency of leptin are located in respect to the presence of leptin on that DNA

Answer 6

Downstream

Question 7

In less than how much weight loss we stop the pharmacology treatment

Answer 7

Less than 5% over 12 months

Question 8

How does the orlistat medication works

Answer 8

Inhibit lipase In the intestines

Question 9

Which side effects Orlistat has

Answer 9

mostly as the digestive system
inhibits absorption of fat-soluble vitamins
From google - 
Gas (flatulence) with discharge.
Fatty/oily stools
Increased defecation
Fecal incontinence/inability to control bowel movements
Urgent bowel movements
Loose stools
Clay-colored stools
Diarrhea

Question 10

How orlistat medication affect development of diabetes

Answer 10

Inhibits development of new diabetes

Question 11

How phentermine helps to decreaes weight gain

Answer 11

Suppresses hunger by release of norepinephrine and activates POMC

Question 12

How topiramate helps weight less

Answer 12

Activates GABA which inhibits AgRP/NPY neurons in the hypothalamus

Question 13

Does the combination of phentermine and topiramate is dangerous

Answer 13

It is, but effective

Question 14

How we should treat a patient that gets Orlistat

Answer 14

Subscribe them vitamins that are soluble in fat

Question 15

What is glp1

Answer 15

Hormone that increase secretion of insulin

Question 16

Liraglutide is an analog to which hormone

Answer 16

GLP-1

Question 17

What is considered the most effective drug for weight loss

Answer 17

Combination of Phanteramine and topiromate

Question 18

Semaglutide is analog of which hormone

Answer 18

Glp1

Question 19

How glucagon has the potential to be a treatment against obesity

Answer 19

Increases level of energy expenditure

Question 20

Which Hormonal combination can be successful in weight lowering

Answer 20

GLP 1 and glucagone

Question 21

Which combination of hormones can be beneficial for weight loss beside glucagon with GLP1

Answer 21

Glp1 and gip

Question 22

Where incertines are active

Answer 22

Nervous system and digestive system

Question 23

How peptide YY helps to weight loss

Answer 23

reduce hunger by inhibition of AgRP/NPY
בבני אדם הפפטיד נמצא ברמות גבוהות ברוק, וכנראה שמדובר בחלק עיקרי
בפעולה של הפפטיד

Question 24

How analog of amylin can help weight loss

Answer 24

with secretion of insulin - Increases satiety, decreasing caloric intake

Question 25

What is usually the complexity with leptin

Answer 25

Problem with the leptin receptors and not the lack of the hormone

Question 26

מה תפקידה של SGLT2?

Answer 26

אחראי על הספיגה מחדש של כ-90% מהגלוקוז אשר עובר בלולאה הפרוקסימלית בגלומרולוס (Glomerulus)

Question 27

How inhibition of sglt2 helps lower glucose 

Answer 27

It increases urinary glucose excretion

Question 28

How inhibition of sglt1 helps lowering glucose

Answer 28

Inhibit absorption of intestinal sugar

Question 29

What is the name of the drug that works as an inhibitor of the sodium glucose transporter

Answer 29

Canagliflozin

Question 30

Does FXR and GPR131 helps weight loss

Answer 30

Yes

Question 31

Why CB1R blockers were reduced from market

Answer 31

Caused depression

Question 32

In which way the psychiatric effect of CB1R blockers been tried to avoid

Answer 32

Avoid crossing BBB

Question 33

Does hypothalamus is after bbb

Answer 33

No

Question 34

how SGLT2 reduces glucose?

Answer 34

inhibit the reabsorption of the glucose in the glomerulus