Dani Brain 3

Question 1

What is the major risk factor of Alzheimer

Answer 1

Aging

Question 2

When is it possible to declare in full certainty that person is sick with Alzheimer’s

Answer 2

Only post death surgery

Question 3

Which areas of the brain are the first to be damaged in Alzheimer disease

Answer 3

Hypocampus

Question 4

Aggregation of which protein can cause Alzheimer’s disease

Answer 4

Amyloid precursor protein

Question 5

Creating which part the amyloid protein is supposedly to take part in

Answer 5

Synapses

Question 6

Which enzyme cuts the emulloid precourser protein in the N terminal which turns out as amyloid Beta

Answer 6

BACE protein

Question 7

What is the name of that short amyloid peptide that aggregate and sinks in the brain

Answer 7

Amyloid beta

Question 8

Which pathologies can cause aggregation and sendimentation of that amyloid beta protein

Answer 8

Cell death
Porous membrane
Damaging process releasing of glutamate that cause it’s accumulation and activation of glial cell and increased entrance of calcium ions to the cell that will eventually cause Cell death

Question 9

Where does amyloid protein sink in the brain

Answer 9

In the cells
between cells
in the blood vessels

Question 10

Which protein that serves as a scaffold of that microtubule is damaged in the Alzheimer’s disease

Answer 10

TAU protein

Question 11

What happened to that tau protein that causes in its aggregation and eventually Alzheimer

Answer 11

Hyper phosphorylation

Question 12

Mutation in which Gene is the most common reason for developing Alzheimer’s in an early age

Answer 12

PS1

Question 13

Mutation in which apolipoprotein can result in developing Alzheimer’s disease in Older ages

Answer 13

ApoE

Question 14

Aggregation of which Apple E protein can result into developing Alzheimer in older ages

Answer 14

ApoE4

Question 15

What is the role of the ApoE protein

Answer 15

Carry cholesterol

Question 16

Which pathology occurs in higher rate at mice that was fed with high fat diet

Answer 16

Sink of amyloid protein

Question 17

Did the mice that was fed with high fat diet developed hyper phosphorylation in the tau protein

Answer 17

No

Question 18

Occurrence of which disease that Statin drug can delay or inhibit

Answer 18

Dementia

Question 19

Does Alzheimer suffers also has the vascular pathology

Answer 19

The vast majority do

Question 20

Can statin cross BBB

Answer 20

Yes

Question 21

How prostaglandins can affect inflammation in the brain

Answer 21

Increase it

Question 22

From which compound does the prostaglandin derived

Answer 22

Arachidonic acid

Question 23

Which enzyme catalyzes formation of prostaglandins from Archidona acid

Answer 23

Cox2

Question 24

Which Cox enzyme considered the good Cox

Answer 24

Cox1

Question 25

In which cells cocks too is mainly present

Answer 25

Inflammatory and immune cells

Question 26

Which brsin cells are part of the immune system

Answer 26

Microglia

Question 27

How can the microglia cells be targeted into dealing with Alzheimer

Answer 27

Decrease the stress that cause activation of glio cells and secretion of inflammatory compound

Question 28

Which type of drugs can reduce stress and decrease inflammation in the brain and that’s Health Alzheimer sufferers

Answer 28

NSAID

Question 29

Is insulin significant for the reception of glucose in the brain

Answer 29

No

Question 30

Which glucose receptors are present in the brain

Answer 30

1 and 3

Question 31

Which role does the insulin have in the development of the brain

Answer 31

Development of glial cells

Question 32

How neuronal insulin resistance affect the tau protein

Answer 32

Causes autophosphorylation

Question 33

What is type three diabetes

Answer 33

Situation where the neurons does not respond to insulin