Dani Brain 3 Flashcards
What is the major risk factor of Alzheimer
Aging
When is it possible to declare in full certainty that person is sick with Alzheimer’s
Only post death surgery
Which areas of the brain are the first to be damaged in Alzheimer disease
Hypocampus
Aggregation of which protein can cause Alzheimer’s disease
Amyloid precursor protein
Creating which part the amyloid protein is supposedly to take part in
Synapses
Which enzyme cuts the emulloid precourser protein in the N terminal which turns out as amyloid Beta
BACE protein
What is the name of that short amyloid peptide that aggregate and sinks in the brain
Amyloid beta
Which pathologies can cause aggregation and sendimentation of that amyloid beta protein
Cell death
Porous membrane
Damaging process releasing of glutamate that cause it’s accumulation and activation of glial cell and increased entrance of calcium ions to the cell that will eventually cause Cell death
Where does amyloid protein sink in the brain
In the cells
between cells
in the blood vessels
Which protein that serves as a scaffold of that microtubule is damaged in the Alzheimer’s disease
TAU protein
What happened to that tau protein that causes in its aggregation and eventually Alzheimer
Hyper phosphorylation
Mutation in which Gene is the most common reason for developing Alzheimer’s in an early age
PS1
Mutation in which apolipoprotein can result in developing Alzheimer’s disease in Older ages
ApoE
Aggregation of which Apple E protein can result into developing Alzheimer in older ages
ApoE4
What is the role of the ApoE protein
Carry cholesterol
Which pathology occurs in higher rate at mice that was fed with high fat diet
Sink of amyloid protein
Did the mice that was fed with high fat diet developed hyper phosphorylation in the tau protein
No
Occurrence of which disease that Statin drug can delay or inhibit
Dementia
Does Alzheimer suffers also has the vascular pathology
The vast majority do
Can statin cross BBB
Yes
How prostaglandins can affect inflammation in the brain
Increase it
From which compound does the prostaglandin derived
Arachidonic acid
Which enzyme catalyzes formation of prostaglandins from Archidona acid
Cox2
Which Cox enzyme considered the good Cox
Cox1
In which cells cocks too is mainly present
Inflammatory and immune cells
Which brsin cells are part of the immune system
Microglia
How can the microglia cells be targeted into dealing with Alzheimer
Decrease the stress that cause activation of glio cells and secretion of inflammatory compound
Which type of drugs can reduce stress and decrease inflammation in the brain and that’s Health Alzheimer sufferers
NSAID
Is insulin significant for the reception of glucose in the brain
No
Which glucose receptors are present in the brain
1 and 3
Which role does the insulin have in the development of the brain
Development of glial cells
How neuronal insulin resistance affect the tau protein
Causes autophosphorylation
What is type three diabetes
Situation where the neurons does not respond to insulin
