Noga Methabolism Clock Flashcards
What is rq
Co2 eliminated/o2 consumed
Where are located our biological central clock
In the suprachiasmatic nucleus
What keeps the day cycle constant?
Exposure to light
What will happen to our daily cycle without exposure to light
Will delay every day a little bit but keep the a bit more than 24 hour routine
What’s the name of the main clock
SCN clock
Who regulates the metabolism
Main and peripheral clock, enzymes, hormones
Does the glucose levels are rythmic?
Yes
Before activity hours what happened to glucose level
Increases
Before hours of activity what happens to levels of glucose absorption
High as well as the levels of glucose formation
Does the SCN control glucose concentration and glucose usage in separate mechanisms
Yes
What can cause daily rythmus
Daily rytmus in insulin sensitivity
Glucose production
Rhythms as a response to beta cells to glucose
Which method of disease can be developed due to disturbances in the circadian clock
Type two diabetes
Does glucose rhythms has Changed due to alternation of the sleep and waking hours
No
How destruction between the biological clock and glucose metabolism can happend
Distruption between environment and the clock
disruption between the SCN to the peripheral clocks
disruption between organs
Disruption between cells
disruption between gene expression
What was the response to glucose in a system that were knocked out for the Bmal gene
Low glucose
When does the melatonin is secreted
At night, in response to darkness
How does melatonin affect on mice
More aggressive and hungry because they are most activated at night
How bright light treatment affect gene expression
Increases it
How bright light treatment effect glucose insulin and type 2 diabetis
Lowers them
In which time was the common ancestor of mammals active
At night
When in the evolution mammels became morning animals
Pretty late
