Wow Flashcards
Normal random activity but characterized by abnormal chemotactic activity
Job’s syndrome
Abnormal random activity and abnormal chemotactic activity
Lazy Leukocyte syndrome
TEST FOR CGD
- Nitro blue tetrazolium reduction test
2.Flow cytometry using dihydrorhodamine-123
Characterized by deficiency of MPO in the primary granules of neutrophil and lysosomes of monocyte
Myeloperoxidase deficiency /Alius-Grignaschi anomaly
Defects originates in the mutation of MPO gene on chromosome 17
Myeloperoxidase deficiency /Alius-Grignaschi anomaly
In the hematology laboratory, MPO deficiency can be easily detected by the ______, which uses myeloperoxidase to identify cells in the automated differential
Siemens Advia analyzer
can present in association with hematologic neoplasms and lead poisoning
Acquired myeloperoxidase deficiency
Neutrophil with homogenous round body
LE cells
LE cells is found on
SLE
It is demonstrated in buffy coat preparation
LE cells
Smooth and evenly stained
LE cells
Monocyte with ingested lymphocyte
Tart cells
Rough and unevenly distributed
Tart cells
Also referred as reactive/variant/stimulated lymphocytes or Downey cells
Atypical lymphocytes
a type of reactive lymphocyte that has some of the morphologic features of plasmacytes
plasmacytoid lymphocyte
Types of Downey cells:
Turk’s irritation cell which is actually a plasmacytoid lymphocyte with large black chromatin
Type I
Types of Downey cells:
found on IM with round mass of chromatin (ballerina skirt appearance)
Type II
Types of Downey cells:
Vacuolated lymphocyte resembling a swiss cheese or moth-eaten appearance
Type III
Originally B cells with hair like projection which are identified by being TRAP resistance
Hairy cell
Destroyed lymphocyte can be found on
A. Pressured smear preparation (artifacts)
B. CLL – Chronic lymphocytic leukemia (thumbprint appearance)
Basket Cell / Smudge cell
A T lymphocyte with cerebriform nucleus (Brain-like) usually seen in mycosis fungoides and Sezary syndrome
Sezary cells
Cells are similar to normal lymphocytes except that the nucleus is notched, lobulated, and cloverleaf-like
Reider cells
Occurs in CLL (pathologic) or artificially through blood smear preparation
Reider cells
A plasma cell with red to pink cytoplasm; associated with increased IgA and usually seen in Multiple Myeloma
Flame cells
Individual globules of immunoglobulins
Russel bodies
Intranuclear protein inclusions
Dutcher’s bodies
A plasma cell with vacuoles; with large protein globules called as “Russel bodies”
Grape cell/ Berry/ Morula or MOTT cells
Caused by unknown deficiency. Macrophage appears as sea-blue in color
Sea blue histiocytosis
Characterized by deficiency in Hexosaminidase A, an enzyme which leads to the accumulation of glycolipids and gangliosides exhibited by vacuolated cytoplasm.
Tay-sachs disease
Characterized by deficiency in Hexosaminidase A and B enzyme which leads to the accumulation of glycolipids and gangliosides exhibited by vacuolated cytoplasm.
Sand Hoff’s disease
deficiency of a-galactosidase
Fabry disease
deficiency of ceramidase
Farber’s disease
deficiency of galactocerebrosidase / B-galactosidase
Krabbe’s disease
deficiency of arylsulfatase A
Metachromatic leukodystrophy-
Primarily a disease of childhood and adolescence, accounting for 25% of childhood cancers and up to 75% of childhood leukemia
Acute lymphoblastic leukemia (ALL)
the most common type of leukemia in adults, and the incidence increases with age.
Acute myeloid leukemia (AML)
appears to involve B lymphocytes, occurring more in men than in
women
Chronic Lymphocytic leukemia (CLL)
Clinical signs are lymphadenopathy, fatigue, weight loss, splenomegaly, and hepatomegaly
Chronic Lymphocytic leukemia (CLL)
bone marrow and peripheral blood films show small lymphoid cells with a characteristically coarse chromatin (“soccer-ball” pattern), absent or inconspicuous nucleoli, and scant cytoplasm
Chronic Lymphocytic leukemia (CLL)
A myeloproliferative disorder characterized by pancytosis
Chronic Myelogenous Leukemia (CML)
90% of cases are positive for Philadelphia chromosome
Chronic Myelogenous Leukemia (CML)
