Wow

Question 1

Normal random activity but characterized by abnormal chemotactic activity

Answer 1

Job’s syndrome

Question 2

Abnormal random activity and abnormal chemotactic activity

Answer 2

Lazy Leukocyte syndrome

Question 3

TEST FOR CGD

Answer 3

1. Nitro blue tetrazolium reduction test
   2.Flow cytometry using dihydrorhodamine-123

Question 4

Characterized by deficiency of MPO in the primary granules of neutrophil and lysosomes of monocyte

Answer 4

Myeloperoxidase deficiency /Alius-Grignaschi anomaly

Question 5

Defects originates in the mutation of MPO gene on chromosome 17

Answer 5

Myeloperoxidase deficiency /Alius-Grignaschi anomaly

Question 6

In the hematology laboratory, MPO deficiency can be easily detected by the ______, which uses myeloperoxidase to identify cells in the automated differential

Answer 6

Siemens Advia analyzer

Question 7

can present in association with hematologic neoplasms and lead poisoning

Answer 7

Acquired myeloperoxidase deficiency

Question 8

Neutrophil with homogenous round body

Answer 8

LE cells

Question 9

LE cells is found on

Answer 9

SLE

Question 10

It is demonstrated in buffy coat preparation

Answer 10

LE cells

Question 11

Smooth and evenly stained

Answer 11

LE cells

Question 12

Monocyte with ingested lymphocyte

Answer 12

Tart cells

Question 13

Rough and unevenly distributed

Answer 13

Tart cells

Question 14

Also referred as reactive/variant/stimulated lymphocytes or Downey cells

Answer 14

Atypical lymphocytes

Question 15

a type of reactive lymphocyte that has some of the morphologic features of plasmacytes

Answer 15

plasmacytoid lymphocyte

Question 16

Types of Downey cells:

Turk’s irritation cell which is actually a plasmacytoid lymphocyte with large black chromatin

Answer 16

Type I

Question 17

Types of Downey cells:

found on IM with round mass of chromatin (ballerina skirt appearance)

Answer 17

Type II

Question 18

Types of Downey cells:

Vacuolated lymphocyte resembling a swiss cheese or moth-eaten appearance

Answer 18

Type III

Question 19

Originally B cells with hair like projection which are identified by being TRAP resistance

Answer 19

Hairy cell

Question 20

Destroyed lymphocyte can be found on
A. Pressured smear preparation (artifacts)
B. CLL – Chronic lymphocytic leukemia (thumbprint appearance)

Answer 20

Basket Cell / Smudge cell

Question 21

A T lymphocyte with cerebriform nucleus (Brain-like) usually seen in mycosis fungoides and Sezary syndrome

Answer 21

Sezary cells

Question 22

Cells are similar to normal lymphocytes except that the nucleus is notched, lobulated, and cloverleaf-like

Answer 22

Reider cells

Question 23

Occurs in CLL (pathologic) or artificially through blood smear preparation

Answer 23

Reider cells

Question 24

A plasma cell with red to pink cytoplasm; associated with increased IgA and usually seen in Multiple Myeloma

Answer 24

Flame cells

Question 25

Individual globules of immunoglobulins

Answer 25

Russel bodies

Question 26

Intranuclear protein inclusions

Answer 26

Dutcher’s bodies

Question 27

A plasma cell with vacuoles; with large protein globules called as “Russel bodies”

Answer 27

Grape cell/ Berry/ Morula or MOTT cells

Question 28

Caused by unknown deficiency. Macrophage appears as sea-blue in color

Answer 28

Sea blue histiocytosis

Question 29

Characterized by deficiency in Hexosaminidase A, an enzyme which leads to the accumulation of glycolipids and gangliosides exhibited by vacuolated cytoplasm.

Answer 29

Tay-sachs disease

Question 30

Characterized by deficiency in Hexosaminidase A and B enzyme which leads to the accumulation of glycolipids and gangliosides exhibited by vacuolated cytoplasm.

Answer 30

Sand Hoff’s disease

Question 31

deficiency of a-galactosidase

Answer 31

Fabry disease

Question 32

deficiency of ceramidase

Answer 32

Farber’s disease

Question 33

deficiency of galactocerebrosidase / B-galactosidase

Answer 33

Krabbe’s disease

Question 34

deficiency of arylsulfatase A

Answer 34

Metachromatic leukodystrophy-

Question 35

Primarily a disease of childhood and adolescence, accounting for 25% of childhood cancers and up to 75% of childhood leukemia

Answer 35

Acute lymphoblastic leukemia (ALL)

Question 36

the most common type of leukemia in adults, and the incidence increases with age.

Answer 36

Acute myeloid leukemia (AML)

Question 37

appears to involve B lymphocytes, occurring more in men than in women

Answer 37

Chronic Lymphocytic leukemia (CLL)

Question 38

Clinical signs are lymphadenopathy, fatigue, weight loss, splenomegaly, and hepatomegaly

Answer 38

Chronic Lymphocytic leukemia (CLL)

Question 39

bone marrow and peripheral blood films show small lymphoid cells with a characteristically coarse chromatin (“soccer-ball” pattern), absent or inconspicuous nucleoli, and scant cytoplasm

Answer 39

Chronic Lymphocytic leukemia (CLL)

Question 40

A myeloproliferative disorder characterized by pancytosis

Answer 40

Chronic Myelogenous Leukemia (CML)

Question 41

90% of cases are positive for Philadelphia chromosome

Answer 41

Chronic Myelogenous Leukemia (CML)