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Hematology > Wow > Flashcards

Wow Flashcards

1
Q

Normal random activity but characterized by abnormal chemotactic activity

A

Job’s syndrome

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2
Q

Abnormal random activity and abnormal chemotactic activity

A

Lazy Leukocyte syndrome

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3
Q

TEST FOR CGD

A
  1. Nitro blue tetrazolium reduction test
    2.Flow cytometry using dihydrorhodamine-123
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4
Q

Characterized by deficiency of MPO in the primary granules of neutrophil and lysosomes of monocyte

A

Myeloperoxidase deficiency /Alius-Grignaschi anomaly

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5
Q

Defects originates in the mutation of MPO gene on chromosome 17

A

Myeloperoxidase deficiency /Alius-Grignaschi anomaly

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6
Q

In the hematology laboratory, MPO deficiency can be easily detected by the ______, which uses myeloperoxidase to identify cells in the automated differential

A

Siemens Advia analyzer

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7
Q

can present in association with hematologic neoplasms and lead poisoning

A

Acquired myeloperoxidase deficiency

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8
Q

Neutrophil with homogenous round body

A

LE cells

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9
Q

LE cells is found on

A

SLE

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10
Q

It is demonstrated in buffy coat preparation

A

LE cells

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11
Q

Smooth and evenly stained

A

LE cells

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12
Q

Monocyte with ingested lymphocyte

A

Tart cells

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13
Q

Rough and unevenly distributed

A

Tart cells

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14
Q

Also referred as reactive/variant/stimulated lymphocytes or Downey cells

A

Atypical lymphocytes

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15
Q

a type of reactive lymphocyte that has some of the morphologic features of plasmacytes

A

plasmacytoid lymphocyte

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16
Q

Types of Downey cells:

Turk’s irritation cell which is actually a plasmacytoid lymphocyte with large black chromatin

A

Type I

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17
Q

Types of Downey cells:

found on IM with round mass of chromatin (ballerina skirt appearance)

A

Type II

18
Q

Types of Downey cells:

Vacuolated lymphocyte resembling a swiss cheese or moth-eaten appearance

A

Type III

19
Q

Originally B cells with hair like projection which are identified by being TRAP resistance

A

Hairy cell

20
Q

Destroyed lymphocyte can be found on
A. Pressured smear preparation (artifacts)
B. CLL – Chronic lymphocytic leukemia (thumbprint appearance)

A

Basket Cell / Smudge cell

21
Q

A T lymphocyte with cerebriform nucleus (Brain-like) usually seen in mycosis fungoides and Sezary syndrome

A

Sezary cells

22
Q

Cells are similar to normal lymphocytes except that the nucleus is notched, lobulated, and cloverleaf-like

A

Reider cells

23
Q

Occurs in CLL (pathologic) or artificially through blood smear preparation

A

Reider cells

24
Q

A plasma cell with red to pink cytoplasm; associated with increased IgA and usually seen in Multiple Myeloma

A

Flame cells

25
Q

Individual globules of immunoglobulins

A

Russel bodies

26
Q

Intranuclear protein inclusions

A

Dutcher’s bodies

27
Q

A plasma cell with vacuoles; with large protein globules called as “Russel bodies”

A

Grape cell/ Berry/ Morula or MOTT cells

28
Q

Caused by unknown deficiency. Macrophage appears as sea-blue in color

A

Sea blue histiocytosis

29
Q

Characterized by deficiency in Hexosaminidase A, an enzyme which leads to the accumulation of glycolipids and gangliosides exhibited by vacuolated cytoplasm.

A

Tay-sachs disease

30
Q

Characterized by deficiency in Hexosaminidase A and B enzyme which leads to the accumulation of glycolipids and gangliosides exhibited by vacuolated cytoplasm.

A

Sand Hoff’s disease

31
Q

deficiency of a-galactosidase

A

Fabry disease

32
Q

deficiency of ceramidase

A

Farber’s disease

33
Q

deficiency of galactocerebrosidase / B-galactosidase

A

Krabbe’s disease

34
Q

deficiency of arylsulfatase A

A

Metachromatic leukodystrophy-

35
Q

Primarily a disease of childhood and adolescence, accounting for 25% of childhood cancers and up to 75% of childhood leukemia

A

Acute lymphoblastic leukemia (ALL)

36
Q

the most common type of leukemia in adults, and the incidence increases with age.

A

Acute myeloid leukemia (AML)

37
Q

appears to involve B lymphocytes, occurring more in men than in
women

A

Chronic Lymphocytic leukemia (CLL)

38
Q

Clinical signs are lymphadenopathy, fatigue, weight loss, splenomegaly, and hepatomegaly

A

Chronic Lymphocytic leukemia (CLL)

39
Q

bone marrow and peripheral blood films show small lymphoid cells with a characteristically coarse chromatin (“soccer-ball” pattern), absent or inconspicuous nucleoli, and scant cytoplasm

A

Chronic Lymphocytic leukemia (CLL)

40
Q

A myeloproliferative disorder characterized by pancytosis

A

Chronic Myelogenous Leukemia (CML)

41
Q

90% of cases are positive for Philadelphia chromosome

A

Chronic Myelogenous Leukemia (CML)

Hematology (28 decks)

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