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Hematology > Review > Flashcards

Review Flashcards

1
Q

Variation in shapes of RBC

A

Poikilocytosis

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2
Q

Variation in sizes of RBC

A

Anisocytosis

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3
Q

Leukoerythroblastosis is not associated with

A

Erythroblastosis fetalis (HDN)

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4
Q

Procedure employs blood w/ EDTA diluted with 0.105 M NaCitrate or NSS

A

Modified Westergren

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5
Q

What is the T-cell growth factor and mast cell activating factor effect in stimulating erythroid and myeloid proliferation

A

Interleukin-9 or IL-9

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6
Q

Largest of all hematopoietic stem cells

A

Polyploid megakaryocyte

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7
Q

Which among RBC has figure of 8, loop shaped

A

Cabot rings

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8
Q

Which among cells is the earliest erythroid recognizable precursor

A

pronormoblast

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9
Q

Which of the ff mononuclear cells are w/o specific cytoplasmic granules

A

Lymphocytes

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10
Q

Which ff cell is larger than monocyte w/ irregular cell membrane with blunts and pseudopods

A

Megakaryoblasts

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11
Q

Common precursor for granulocytes, monocytes, erythrocytes and megakaryocytes

A

Myeloid stem cells

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12
Q

Rbc thinner than normal, peripheral rim of hemoglobin w/ dark Hgb containing area

A

Leptocytes

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13
Q

Disintegrating RBC

A

Schistocytes

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14
Q

Cell that has deep purple and paler nucleus
which often nearly hidden by granules

A

Basophils

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15
Q

Last nucleated cell

A

Orthochromic Normoblast

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16
Q

Hematopoietic stem cells also known as CFU- GEM expresses

A

CD34/CD33

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17
Q

Promotes differentiation and maturation of megakaryocytes

A

Thrombopoietin

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18
Q

Large cell w/ single eccentric nucleus has reticular chromatin and prominent nucleolus

A

Osteoblast

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19
Q

Nutritional deficiency of Cobalamine, due to failure of gastric mucosa produce intrinsic factors

A

Pernicious Anemia

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20
Q

During fetal life, all Rbc produce HbF, in adults, 0.2-7% are HbF

A

TRUE

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21
Q

Reticulocytopenia and ABN RBC are primary findings, ABN granulocyte are rare and less than 1% blast cell

A

Refractory Anemia

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22
Q

Acute Myelocytic Leukemia seen in

A

M4

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23
Q

Earliest Thrombopoiesis w/ overlapping lobe and small amount of basophilic cytoplasm

A

Megakaryoblast

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24
Q

Degrades fibrin clot and retract fibrinogen forms FDP

A

Plasmin

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25
Q

Content of eosinophilic specific granules toxic to parasite that neutralize heparin and release histamine

A

Major Basic Protein

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26
Q

Pathway using 2,3-BPG

A

Rapaport- Luebering Shunt

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27
Q

Cooper Cruick Shank method is for

A

Absolute Basophil Count

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28
Q

Result of PT & PTT mixing studies: mixed plasma is normal, after 1-2 hrs it is prolonged, suggestive of

A

Presence of FVIII inhibitor

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29
Q

Lab findings of DIC

A

increase D-dimer, increase PT/PTT, decrease platelet count

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30
Q

Conjugated protein serves as a vehicle of oxygen and carbon dioxide

A

Hemoglobin

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31
Q

Absorbance of spectrophotometer for determining Hgb using HCN

A

540nm

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32
Q

Quantitative measure of Carboxy Hgb

A

Either (Differential spectrophotometer, gas chromatography)

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33
Q

Young cells w/ residual RNA polychromatophilic RBC in air dried film stained with __?

A

Brilliant Cresyl Blue and New Methylene Blue

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34
Q

Bilobed structure which recognized by size and bright red granules:

A

Eosinophil

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35
Q

Abundant blue cytoplasm, eccentric round nucleus w/ light vacuoles w/ well defined golgi zone adjacent to nucleus

A

Plasma Cell

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36
Q

1 g of Hgb carries ___ mg of Iron

A

3.47

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37
Q

Reveals pancytopenia, decrease hematopoietic cell lines resulting to low all blood levels

A

Aplastic Anemia

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38
Q

Genetically impairment of globin synthesis

A

Thallasemia

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39
Q

Which of the ff also called CSF-1

A

Monocyte macrophage CSF

40
Q

Fastest Hgb at pH 8.4 in alkaline medium

A

HbH

41
Q

Hgb not denatured by alkaline solution

A

HbF

42
Q

Variety of Acute leukemia predominant blasts cannot classify using morphologic, cytochemical, ultrastructural and immunologic or DNA analysis

A

Acute undifferentiated Leukemia

43
Q

Normal value of reticulated platelet count

A

3- 20%

44
Q

Term used if RBC is hypochromic and normochromic

A

Anisochromia

45
Q

This are the Pro-Tcell markers except?

A

CD3, CD 7, CD2, CD17

46
Q

Which of the ff refers to total red cell mass

A

absolute polycythemia vera

47
Q

Normal Retic count at birth?

A

3-7%

48
Q

Not required for RBC production

A

Folic Acid, Iron, Protein or Vitamin E

49
Q

Rare autosomal dominant shows pale blue inclusion resembling Dohle bodies

A

May Hegglin Anomaly

50
Q

Autosomal dominant that failure normal segmentation of neutrophils

A

Pelger Huet Anomaly

51
Q

AML w/ minimal differentiation

A

M0

52
Q

A molecule of Hgb is consist of ___
polypeptide chain

A

2

53
Q

A mixture of oxidized denatured Hgb during
oxidative hemolysis

A

SulfHgb

54
Q

Principle involved in automated counting

A

Electric Impedance

55
Q

Measures fibrin clot from activation of F7 to fibrin stabilizing clot

A

PT

56
Q

Lymphoreticular neoplasm involved in skin

A

mycosis fungoides

57
Q

Global test adequacy of primary hemostasis

A

template BT

58
Q

Activator that initiates the fibrinolysis and convert plasminogen to plasmin

A

t-PA

59
Q

Primary test in diagnosis of hairy cell leukemia

A

ACP

60
Q

Decrease function of F2, 7, 10 (Protein C, Protein S)

A

warfarin

61
Q

Prolonged pt and normal ptt seen in patients with deficiencies in which factor in intrinsic factor

A

F8,9, 11, 12

62
Q

Prolonged pt and normal ptt seen in patients with deficiencies in which factor in extrinsic factor

A

F7

63
Q

Cofactor of required in activation of F2 by activated F8

A

F5

64
Q

Diluting fluid in platelet count in phase contrast

A

1%NH4Oxalate

65
Q

In phase contrast microscope, how many squares in platelets in improved neubauer

A

25 small squares

66
Q

Light angle scatter in laser-based cell counting chamber is used to measure

A

cytoplasmic granularity

67
Q

Patients with infectious mononucleosis, this blood cell is infected

A

B-lymphocyte

68
Q

Inhibits factor 2,9,7,11,10, enhances the activity of anti-thrombin as natural anticoagulant

A

Heparin

69
Q

Which of the ff not function of spleen as hematopoietic origin

A

secretion of mitogen

70
Q

Immature non-nucleated RBC with RNA granules

A

Reticulocytes

71
Q

Not associated with sickle cell

A

promotes spleen destruction

72
Q

Tissue extract with phospholipid and tissue factor that activates F7 in extrinsic pathway

A

thromboplastin

73
Q

Use to connote the appearance of neoplastic cell w/ non-hodgkins lymphoma

A

lymphosarcoma cell leukemia

74
Q

This altered of immune response against host own immune system that produce Antibody against itself

A

AutoImmune Hemolytic Anemia

75
Q

Useful in identifying w/ Beta-Thalassemia trait that elevated upto 7%

A

HbA2

76
Q

Chronic progressive panmyelosis characterized by triad findings vary in fibrosis in the marrow, splenomegaly and leukoerythroblastic anemia

A

Myelofibrosis w/ myeloid metaplasia

77
Q

Sensitive test in folate or cobalamine deficiency. Measures ability of marrow cells in vitro to utilize deoxyuridine in DNA synthesis

A

deoxyuridine suppression test

78
Q

Life span of basophil in bone marrow:

A

7 days

79
Q

Hematopoiesis begins at the 6th week of fetal life

A

Liver

80
Q

Majority of iron bound to _____ which has capacity to bind 331 mg of iron/dl

A

Transferrin

81
Q

Abnormal RBC due to abnormal radium potassium ratio in the RBC

A

Stomatocytes

82
Q

F8 deficiency

A

Hemophilia A

83
Q

Average concentration HgB in a given RBC

A

MCHC

84
Q

Not considered myeloproliferative disorder

A

AML

85
Q

Cytokines produced by macrophages and kupffer cell

A

IL-18

86
Q

HgB constituent that may degraded and return to amino acid pool

A

Globin

87
Q

Last stage of granulocytic that capable of mitosis

A

Myelocyte

88
Q

Production of azurophilic granules

A

Promyelocyte

89
Q

Water soluble complex of ferric salt and protein

A

Ferritin

90
Q

Platelet survival

A

8-11 days (in vivo) 3-5 days (in vitro)

91
Q

Provides initial hemostasis due to injury

A

platelet plug

92
Q

Condition of panmyelosis with increase megakaryocytes, granulocytes, erythrocytes

A

Polycythemia vera

93
Q

General measure in intrinsic and common pathway

A

PTT

94
Q

General measure in extrinsic and common pathway

A

PT

95
Q

An 18- Kda produce by activated T-cell and mast cell

A

IL-4

Hematology (28 decks)

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