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Hematology > Review > Flashcards

Review Flashcards

1
Q

Variation in shapes of RBC

A

Poikilocytosis

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2
Q

Variation in sizes of RBC

A

Anisocytosis

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3
Q

Leukoerythroblastosis is not associated with

A

Erythroblastosis fetalis (HDN)

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4
Q

Procedure employs blood w/ EDTA diluted with 0.105 M NaCitrate or NSS

A

Modified Westergren

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5
Q

What is the T-cell growth factor and mast cell activating factor effect in stimulating erythroid and myeloid proliferation

A

Interleukin-9 or IL-9

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6
Q

Largest of all hematopoietic stem cells

A

Polyploid megakaryocyte

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7
Q

Which among RBC has figure of 8, loop shaped

A

Cabot rings

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8
Q

Which among cells is the earliest erythroid recognizable precursor

A

pronormoblast

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9
Q

Which of the ff mononuclear cells are w/o specific cytoplasmic granules

A

Lymphocytes

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10
Q

Which ff cell is larger than monocyte w/ irregular cell membrane with blunts and pseudopods

A

Megakaryoblasts

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11
Q

Common precursor for granulocytes, monocytes, erythrocytes and megakaryocytes

A

Myeloid stem cells

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12
Q

Rbc thinner than normal, peripheral rim of hemoglobin w/ dark Hgb containing area

A

Leptocytes

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13
Q

Disintegrating RBC

A

Schistocytes

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14
Q

Cell that has deep purple and paler nucleus
which often nearly hidden by granules

A

Basophils

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15
Q

Last nucleated cell

A

Orthochromic Normoblast

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16
Q

Hematopoietic stem cells also known as CFU- GEM expresses

A

CD34/CD33

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17
Q

Promotes differentiation and maturation of megakaryocytes

A

Thrombopoietin

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18
Q

Large cell w/ single eccentric nucleus has reticular chromatin and prominent nucleolus

A

Osteoblast

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19
Q

Nutritional deficiency of Cobalamine, due to failure of gastric mucosa produce intrinsic factors

A

Pernicious Anemia

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20
Q

During fetal life, all Rbc produce HbF, in adults, 0.2-7% are HbF

A

TRUE

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21
Q

Reticulocytopenia and ABN RBC are primary findings, ABN granulocyte are rare and less than 1% blast cell

A

Refractory Anemia

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22
Q

Acute Myelocytic Leukemia seen in

A

M4

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23
Q

Earliest Thrombopoiesis w/ overlapping lobe and small amount of basophilic cytoplasm

A

Megakaryoblast

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24
Q

Degrades fibrin clot and retract fibrinogen forms FDP

A

Plasmin

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25
Content of eosinophilic specific granules toxic to parasite that neutralize heparin and release histamine
Major Basic Protein
26
Pathway using 2,3-BPG
Rapaport- Luebering Shunt
27
Cooper Cruick Shank method is for
Absolute Basophil Count
28
Result of PT & PTT mixing studies: mixed plasma is normal, after 1-2 hrs it is prolonged, suggestive of
Presence of FVIII inhibitor
29
Lab findings of DIC
increase D-dimer, increase PT/PTT, decrease platelet count
30
Conjugated protein serves as a vehicle of oxygen and carbon dioxide
Hemoglobin
31
Absorbance of spectrophotometer for determining Hgb using HCN
540nm
32
Quantitative measure of Carboxy Hgb
Either (Differential spectrophotometer, gas chromatography)
33
Young cells w/ residual RNA polychromatophilic RBC in air dried film stained with __?
Brilliant Cresyl Blue and New Methylene Blue
34
Bilobed structure which recognized by size and bright red granules:
Eosinophil
35
Abundant blue cytoplasm, eccentric round nucleus w/ light vacuoles w/ well defined golgi zone adjacent to nucleus
Plasma Cell
36
1 g of Hgb carries ___ mg of Iron
3.47
37
Reveals pancytopenia, decrease hematopoietic cell lines resulting to low all blood levels
Aplastic Anemia
38
Genetically impairment of globin synthesis
Thallasemia
39
Which of the ff also called CSF-1
Monocyte macrophage CSF
40
Fastest Hgb at pH 8.4 in alkaline medium
HbH
41
Hgb not denatured by alkaline solution
HbF
42
Variety of Acute leukemia predominant blasts cannot classify using morphologic, cytochemical, ultrastructural and immunologic or DNA analysis
Acute undifferentiated Leukemia
43
Normal value of reticulated platelet count
3- 20%
44
Term used if RBC is hypochromic and normochromic
Anisochromia
45
This are the Pro-Tcell markers except?
CD3, CD 7, CD2, CD17
46
Which of the ff refers to total red cell mass
absolute polycythemia vera
47
Normal Retic count at birth?
3-7%
48
Not required for RBC production
Folic Acid, Iron, Protein or Vitamin E
49
Rare autosomal dominant shows pale blue inclusion resembling Dohle bodies
May Hegglin Anomaly
50
Autosomal dominant that failure normal segmentation of neutrophils
Pelger Huet Anomaly
51
AML w/ minimal differentiation
M0
52
A molecule of Hgb is consist of ___ polypeptide chain
2
53
A mixture of oxidized denatured Hgb during oxidative hemolysis
SulfHgb
54
Principle involved in automated counting
Electric Impedance
55
Measures fibrin clot from activation of F7 to fibrin stabilizing clot
PT
56
Lymphoreticular neoplasm involved in skin
mycosis fungoides
57
Global test adequacy of primary hemostasis
template BT
58
Activator that initiates the fibrinolysis and convert plasminogen to plasmin
t-PA
59
Primary test in diagnosis of hairy cell leukemia
ACP
60
Decrease function of F2, 7, 10 (Protein C, Protein S)
warfarin
61
Prolonged pt and normal ptt seen in patients with deficiencies in which factor in intrinsic factor
F8,9, 11, 12
62
Prolonged pt and normal ptt seen in patients with deficiencies in which factor in extrinsic factor
F7
63
Cofactor of required in activation of F2 by activated F8
F5
64
Diluting fluid in platelet count in phase contrast
1%NH4Oxalate
65
In phase contrast microscope, how many squares in platelets in improved neubauer
25 small squares
66
Light angle scatter in laser-based cell counting chamber is used to measure
cytoplasmic granularity
67
Patients with infectious mononucleosis, this blood cell is infected
B-lymphocyte
68
Inhibits factor 2,9,7,11,10, enhances the activity of anti-thrombin as natural anticoagulant
Heparin
69
Which of the ff not function of spleen as hematopoietic origin
secretion of mitogen
70
Immature non-nucleated RBC with RNA granules
Reticulocytes
71
Not associated with sickle cell
promotes spleen destruction
72
Tissue extract with phospholipid and tissue factor that activates F7 in extrinsic pathway
thromboplastin
73
Use to connote the appearance of neoplastic cell w/ non-hodgkins lymphoma
lymphosarcoma cell leukemia
74
This altered of immune response against host own immune system that produce Antibody against itself
AutoImmune Hemolytic Anemia
75
Useful in identifying w/ Beta-Thalassemia trait that elevated upto 7%
HbA2
76
Chronic progressive panmyelosis characterized by triad findings vary in fibrosis in the marrow, splenomegaly and leukoerythroblastic anemia
Myelofibrosis w/ myeloid metaplasia
77
Sensitive test in folate or cobalamine deficiency. Measures ability of marrow cells in vitro to utilize deoxyuridine in DNA synthesis
deoxyuridine suppression test
78
Life span of basophil in bone marrow:
7 days
79
Hematopoiesis begins at the 6th week of fetal life
Liver
80
Majority of iron bound to _____ which has capacity to bind 331 mg of iron/dl
Transferrin
81
Abnormal RBC due to abnormal radium potassium ratio in the RBC
Stomatocytes
82
F8 deficiency
Hemophilia A
83
Average concentration HgB in a given RBC
MCHC
84
Not considered myeloproliferative disorder
AML
85
Cytokines produced by macrophages and kupffer cell
IL-18
86
HgB constituent that may degraded and return to amino acid pool
Globin
87
Last stage of granulocytic that capable of mitosis
Myelocyte
88
Production of azurophilic granules
Promyelocyte
89
Water soluble complex of ferric salt and protein
Ferritin
90
Platelet survival
8-11 days (in vivo) 3-5 days (in vitro)
91
Provides initial hemostasis due to injury
platelet plug
92
Condition of panmyelosis with increase megakaryocytes, granulocytes, erythrocytes
Polycythemia vera
93
General measure in intrinsic and common pathway
PTT
94
General measure in extrinsic and common pathway
PT
95
An 18- Kda produce by activated T-cell and mast cell
IL-4

Hematology (28 decks)

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