Hematopoiesis

Question 1

Capable of self-renewal and directed differentiation into all required cell lineages

Answer 1

HSC

Question 2

Mesoblastic phase begins at

Answer 2

19th day of gestation

Question 3

Chief site of Mesoblastic phase

Answer 3

Yolk sac

Question 4

Central cavity of yolk sac

Answer 4

Primitive erythroblasts

Question 5

Important in early embryogenesis to produce hemoglobin (delivery of oxygen)

Answer 5

Primitive erythroblasts

Question 5

Surrounds cavity of yolk sac from blood vessels

Answer 5

Angioblasts

Question 6

Cells of mesodermal origin migrates to the ____ and give rise to HSC for definitive or permanent adult hematopoiesis

Answer 6

AGM region

Question 7

Previously considered only site of definitive hematopoiesis during embryonic development

Answer 7

AGM region

Question 8

Major site of adult blood formation in the embryo

Answer 8

Yolk sac

Question 9

Separated from human umbilical cord blood and could generate hematopoietic as well as endothelial cells in vitro

Answer 9

Flk1-HSCs

Question 10

Present only in mesoblastic phase

Answer 10

Embryonic Hemoglobin

Question 11

Enumerate the embryonic hemoglobin

Answer 11

1. Gower I - 2 epsilon, 2 zeta
2. Gower II - 2 alpha, 2 epsilon
3. Portland - 2 zeta, 2 gamma

Question 12

Hepatic phase begins at

Answer 12

5 to 7 gestational weeks

Question 13

Chief site of hepatic phase

Answer 13

Liver

Question 14

Predominant hemoglobin in the hepatic phase

Answer 14

Fetal hemoglobin

Question 15

Characterized by recognizable clusters of developing erythroblasts, granulocytes, and monocytes

Answer 15

Hepatic phase

Question 16

It signals the beginning of definitive hematopoiesis with a decline in primitive hematopoiesis of the yolk sac

Answer 16

Developing erythroblasts

Question 17

What begins to appear during the hepatic phase

Answer 17

Lymphoid cells

Question 18

Production of megakaryocytes

Answer 18

Hepatic phase

Question 19

First fully developed organ in fetus

Answer 19

Thymus

Question 20

Major site of T cell production

Answer 20

Thymus

Question 21

Organs that produce B cells

Answer 21

Liver and Spleen

Question 22

Adults Predominant Hemoglobin

Answer 22

1. Hb A1: 95% (2 alpha, 2 beta)
2. Hb A2: 2-3% (2 alpha, 2 delta)
3. HbF: 1-2% (2 alpha, 2 gamma)

Question 23

Myeloid phase begins at

Answer 23

5th month of gestation

Question 24

Chief site of myeloid phase

Answer 24

Bone marrow

Question 25

Myeloid phase ends at

Answer 25

24th weeks of gestation

Question 26

During myeloid phase, what migrates into the core of the bone

Answer 26

HSCs and mesenchymal cells

Question 27

What are the adult hematopoietic tissue

Answer 27

Bone marrow Lymph nodes Speen Liver Thymus

Question 28

The bone marrow contains

Answer 28

Erythroid Myeloid Megakaryocytic Lymphoid cells

Question 29

What are the primary lymphoid tissue

Answer 29

bone marrow and thymus

Question 30

What are the secondary lymphoid tissue

Answer 30

Spleen Lymph Mucosa-associated lymphoid tissue