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Hematology > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

1
Q

Capable of self-renewal and directed differentiation into all required cell lineages

A

HSC

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2
Q

Mesoblastic phase begins at

A

19th day of gestation

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3
Q

Chief site of Mesoblastic phase

A

Yolk sac

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4
Q

Central cavity of yolk sac

A

Primitive erythroblasts

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5
Q

Important in early embryogenesis to produce hemoglobin (delivery of oxygen)

A

Primitive erythroblasts

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5
Q

Surrounds cavity of yolk sac from blood vessels

A

Angioblasts

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6
Q

Cells of mesodermal origin migrates to the ____ and give rise to HSC for definitive or permanent adult hematopoiesis

A

AGM region

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7
Q

Previously considered only site of definitive hematopoiesis during embryonic development

A

AGM region

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8
Q

Major site of adult blood formation in the embryo

A

Yolk sac

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9
Q

Separated from human umbilical cord blood and could generate hematopoietic as well as endothelial cells in vitro

A

Flk1-HSCs

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10
Q

Present only in mesoblastic phase

A

Embryonic Hemoglobin

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11
Q

Enumerate the embryonic hemoglobin

A
  1. Gower I - 2 epsilon, 2 zeta
  2. Gower II - 2 alpha, 2 epsilon
  3. Portland - 2 zeta, 2 gamma
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12
Q

Hepatic phase begins at

A

5 to 7 gestational weeks

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13
Q

Chief site of hepatic phase

A

Liver

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14
Q

Predominant hemoglobin in the hepatic phase

A

Fetal hemoglobin

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15
Q

Characterized by recognizable clusters of developing erythroblasts, granulocytes, and monocytes

A

Hepatic phase

16
Q

It signals the beginning of definitive hematopoiesis with a decline in primitive hematopoiesis of the yolk sac

A

Developing erythroblasts

17
Q

What begins to appear during the hepatic phase

A

Lymphoid cells

18
Q

Production of megakaryocytes

A

Hepatic phase

19
Q

First fully developed organ in fetus

A

Thymus

20
Q

Major site of T cell production

A

Thymus

21
Q

Organs that produce B cells

A

Liver and Spleen

22
Q

Adults Predominant Hemoglobin

A
  1. Hb A1: 95% (2 alpha, 2 beta)
  2. Hb A2: 2-3% (2 alpha, 2 delta)
  3. HbF: 1-2% (2 alpha, 2 gamma)
23
Q

Myeloid phase begins at

A

5th month of gestation

24
Q

Chief site of myeloid phase

A

Bone marrow

25
Q

Myeloid phase ends at

A

24th weeks of gestation

26
Q

During myeloid phase, what migrates into the core of the bone

A

HSCs and mesenchymal cells

27
Q

What are the adult hematopoietic tissue

A

Bone marrow
Lymph nodes
Speen
Liver
Thymus

28
Q

The bone marrow contains

A

Erythroid
Myeloid
Megakaryocytic
Lymphoid cells

29
Q

What are the primary lymphoid tissue

A

bone marrow and thymus

30
Q

What are the secondary lymphoid tissue

A

Spleen
Lymph
Mucosa-associated lymphoid tissue

31
Q
A

Hematology (28 decks)

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