Bone marrow

Question 1

Location of the bone marrow

Answer 1

cavities of the cortical bones

Question 2

The bone marrow contains

Answer 2

HSCs
Stromal cells
Blood vessels

Question 3

Main function of the bone marrow

Answer 3

Proliferation and production of blood vessel

Question 4

Projections of calcified bone, radiate out from the bone cortex into the central space

Answer 4

Trabeculae

Question 5

Provides structural support for the developing cells that mature within a sea of interposed mature adipocytes

Answer 5

Trabeculae

Question 6

Haematopoietically active marrow that is composed of developing blood cells and progenitors

Answer 6

Red marrow

Question 7

During infancy, all bones in the body contain primarily ____

Answer 7

red marrow

Question 8

hematopoietically inactive marrow composed primarily of adipocytes, with undifferentiated mesenchymal cells and macrophages

Answer 8

Yellow marrow

Question 9

Capable of reverting back to active marrow in cases of increased demand on the bone marrow, such as in excessive blood loss or hemolysis

Answer 9

Yellow marroe

Question 10

Between what age does the adipocytes become more abundant and begins to occupy the spaces in the long bones previously dominates by active marrow

Answer 10

5-7 years of age

Question 11

process of replacing active marrow by adipocytes during development

Answer 11

RetrogressionR

Question 12

Retrogression results restriction of the active marrow of what bones:

Answer 12

Sternum
Vertebrae
Scapulae
Pelvis
Ribs
Skulls
Proximal portion of the long bones

Question 13

Ratio of the red marrow to the yellow marrow typically decreases with age

Answer 13

Marrow cellularity

Question 14

Originate from mesenchymal cells that migrate into the central cavity of bone

Answer 14

Stromal cells

Question 15

Broad, flat cells that form a single continuous layer along the inner surface of the arteries, veins, and vascular sinuses

Answer 15

Epithelial cells

Question 16

Regulate the flow of particles entering and leaving hematopoietic spaces in the vascular sinuses

Answer 16

Endothelial cells

Question 17

Are large cells with a single fat vacuole

Answer 17

Adipocytes

Question 18

They play a role in regulating the volume of the marrow in which active hematopoiesis occurs

Answer 18

Adipocytes

Question 19

Secrete cytokines or growth factors that positively stimulate HSC members and bone hematopoiesis

Answer 19

Adipocytes

Question 20

Develop in small clusters and the more mature forms are located adjacent to the outer surfaces of the vascular sinuses

Answer 20

Erythroid precursors/Erythroblasts

Question 21

Are located adjacent to the walls of the vascular sinuses, which facilitates the release of platelets into the lumen of the sinus

Answer 21

Megakaryocytes

Question 22

Are located deep within the cords

Answer 22

Immature myeloid (granulocytic) cells