Morphologic abnormalities of Leukocytes Flashcards
decreased nuclear segmentation and distinctive coarse chromatin clumping pattern
Pelger-Huët Anomaly
affects all leukocytes
Pelger-Huët Anomaly
mutation in the lamin beta-
receptor gene.
Pelger-Huët Anomaly
pelger-Huët (PH) nuclei may appear
round, ovoid, or peanut shaped
characteristic spectacle-like
(“pince-nez”) morphology with the nuclei attached by a thin filament
Pelger-Huët Anomaly
associated with severe bacterial infections, HIV, tuberculosis, and mycoplasma pneumonia
Pseudo- or Acquired Pelger-Huët Anomaly
Pseudo- or Acquired Pelger-Huët Anomaly
Number of cells affected
True >68%
Pseudo PHA <35%
Pseudo- or Acquired Pelger-Huët Anomaly
TYPES OF WBC AFFECTED
True: All WBC lineages
Pseudo PHA: Neutrophil only
granulocytes with large, darkly staining metachromatic cytoplasmic granules (large azurophilic granules)
Alder-Reilly Anomaly
What is not affected in the Alder-Riley Anomaly
Leukocyte function
characterized by variable thrombocytopenia, giant platelets, and large Döhle body-like inclusions in neutrophils, eosinophils, basophils, and monocytes
May-Hegglin Anomaly
May-Hegglin Anomaly is a mutation in the
MYH9 gene on chromosome 22q12- 13.3
most patients are asymptomatic, few have a mild bleeding tendencies
May-Hegglin Anomaly
mutations in genes that code for the production of lysosomal enzymes.
Lysosomal Storage Disorders
classified according to the under degraded macromolecule that accumulates in the cell
✓Mucopolysaccharidoses
✓Gaucher Disease
✓Niemann-Pick Disease
