Organs In The Stages Of Hematopoiesis

Question 1

One of the largest organs ni the body

Answer 1

Bone marrow

Question 2

Location: Cavities of the calicotr bones

Answer 2

Bone marrow

Question 3

The bone marrow contains

Answer 3

Hematopoietic stem cells
Stromal cells
Blood cessels

Question 4

Main Function: proliferation and production of blood cell

Answer 4

Bone marrow

Question 5

Projections of calcified bone, radiate out from the bonecortex into the central space. Provide structural support for the developing blood slcel that mature within as e a o finterposed mature adipocytes

Answer 5

Trabeculae

Question 6

hematopoietically active marrow that is composed of developing blood cells and progenitors

Answer 6

Red marrow

Question 7

hematopoietically inactive marrowcomposed primarilyof adipocytes, with undifferentiated mesenchymal cells and macrophages

Answer 7

Yellow marrow

Question 8

capable of reverting back to active marrow ni cases of increased demand on the bone marrow, such as in excessive blood lossor hemolysis

Answer 8

Yellow marrow

Question 9

process of replacing active marrow by adipocytes (yellow marrow) during development. Results restriction of the active marrow in the adult to the sternum, vertebrae, scapulae, pelvis, ribs, skull and proximal portion of the long bones

Answer 9

Retrogression

Question 10

ratio of the red marrowtotheyellow marrowtypically decreases with age

Answer 10

Marrow cellularity

Question 11

Originate from mesenchymal cells that migrateinto the central cavity of bone

Answer 11

Stromal cells

Question 12

Broad, flat cells that form a single continuous layer along the inner surface of the arenes, veins, and vascular sinuses

Answer 12

Endothelial cells

Question 13

Regulate the flow of particles entering and leaving hematopoietic spaces ni thevascular sinuses

Answer 13

Endothelial cells

Question 14

Are large cells with a single fat vacuole and They play a role ni regulating the volume of the marrow in which active hematopolesis occurs

Answer 14

Adipocytes

Question 15

Secrete cytokines or growth factors that positively stimulate HSC members and bonehomeostasis

Answer 15

Adupocytes

Question 16

Main functions of red marrow

Answer 16

Production of Blood cells
Iron storage
B-cell development

Question 17

develop ni small clusters, a n d the more mature forms are located adjacent to the outer surfaces fo the vascular sinuses

Answer 17

Erythroid precursors/ Erythroblasts

Question 18

are located adjacent ot the walls of the vascular sinuses, which facilitates the release of platelets into the lumen of the sinus

Answer 18

Megakaryocytes

Question 19

provide nutrients for t h eosseus bone and the marrow

Answer 19

Periosteal arteries

Question 20

The arteriole branches that enter the inner lining of the cortical bone (endosteum) form ____ which connect ot periosteal capillaries that extend from the periosteal artery

Answer 20

sinusoids (endosteal beds)

Question 21

Cells that is located ni the end-osteal bed receive their nutrients from the nutrient artery

Answer 21

Hematopoietic cells

Question 22

Major site of cell production in the second trimester of fetal development

Answer 22

Liver

Question 23

Function of this organ includes protein synthesis and degradation, CHO and lipid metabolism, drug and toxin clearance, iron recycling and storage, hemoglobin degradation, in which bilirubin is conjugated and transported to the small intestine for eventual excretion

Answer 23

Liver

Question 24

maintain contact with the endothelial cell lining. It removes senescent cells and foreign debris from the blood that circulates through the liver

Answer 24

Kupffer cells

Question 25

liver increases the conjugation of bilirubin and the storage of iron

Answer 25

Severe HemolyticAnemias

Question 26

hereditary or acquired defects ni the enzymes involved ni heme biosynthesis result ni the accumulation of the various intermediary porphyrins that damage hepatocytes, erythrocyte precursors and other tissues

Answer 26

Porphyrias

Question 27

Largest lymphoid organ ni the body lies beneath the diaphragm behehitnd fundusof the stomach ni upper left quadrant of abdomen

Answer 27

Spleen

Question 28

Function of this organ are; sequesters platelets, removal of unwanted/abnormal cells in blood

Answer 28

Spleen