Wounds Flashcards
What is bacterial infection ?
more than 10^5 bacteria per gram of tissue
list the subtypes of surgical site infections
-incisional
-superficial - skin and sub cut
- deep
-organ/space
List the 4 classifications of degree of contamination , describe
-Clean - non-traumatic , non-inflamed , operative wound resp, gastrointestinal, genitourinary and oro-pharyngeal tracts not entered
-Clean-contaminated - operative wound resp, gastrointestinal, genitourinary tract are entered , under controlled conditions without unusual contamination
-Contaminated -open fresh accidental wound , in which gastrointestinal contents or infected urine is spilled or a major break in aseptic technique.
-Dirty -old traumatic wound with purulent discharge , dead tissue ,foreign bodies ,perforated or faecal contamination.
How to reduce infections as well as factors effecting infections ?
-aseptic technique - patient prep, surgeon prep and theatre , sterilisation , disinfect
-age - young animals struggle to have decent immune response , older cell division occurs slower wound take longer to heal
-physical condition - if unwell immune system might not be as responsive
-concurrent metabolic issues - corticosteroids make wound healing harder so longer exposure
-current medication - chemotherapy or corticosteroids make wound healing harder so more prone to infection
In what circumstances would it be appropriate to use antibiotics .
-surgery <90 min
-prosthetic implantation
-pre-existing prosthesis patient undergoing surgical procedure
-severely infected or traumatised wound
prophylactic antibiotics
basically = prevention antibiotics
Prophylactic antibiotic examples and advantages .
-cephalosporin - known as Zinacef - good against gram positive
-Amoxicilin - known as Augmentin good against gram positive and anaerobic
-metronidazole - for anaerobic
What are the 3 phases of wound healing ?
-haemostasis and inflammation
-proliferation
-maturation
Describe the phase of haemostasis.
-injury occurs causing tissue damage
-bv leak
-activates clotting cascade intrinsic and extrinsic
-platelet aggregation and release cytokines
-stabilisation of platelet plug by fibrin formation - stops blood loss
Describe the inflammatory phase of wound healing .
-overlaps with haemostasis
-occurs for the first 72 hours after injury
-vasodilation - need good blood supply for wbc
-cytokines in fibrin clot attract wbc - firstly neutrophills then macrophages
-carry out phagocytosis
Describe the proliferation phase of wound healing .
-can overlap with inflammatory phase
-formation of granulation tissue formed from macrophages, fibroblasts and new bv
-fibroblasts proliferate and produce new extracellular matrix, elastin and collagen ( starts give wound strength )
-then get formation of new epithelial tissue
-myofibroblasts contract cause wound to contract and shrink
-contact inhibition occurs
Define contact inhibition.
when epithelial cells come into contact it inhibits further cell division so end up with smooth layer of epithelial tissue
Describe the maturation phase of wound healing .
-remodelling occurs
-type III (immature ) collagen replaced by type I (mature) collagen
-cross linking of collagen
-change in components of extracellular matrix
-increase tensile strength
- takes weeks to months
State and describe factors effecting wound healing . ( patient , wound , concurrent treatment )
-age - takes longer older rate of cell division and tissue remodelling is slower
-co-morbities e.g cushings , diabetes slow down wound healing
-nutritional status - healing high energy demand
-infection
-location -tension , movement , blood supply
-corticosteroids - delay all stages of wound healing
-radiation cause tissue fibrosis and vascular scarring
Define abrasion
loss of epidermis and some dermis
blunt trauma / shearing
Define evulsion .
-like degloving
-tearing of tissues from attachments
Define incision
created by sharp object
minimal trauma
Define laceration
tearing of wound creating irregular defect
jagged and tears underlying tissue
Define puncture
penetrating wound
iceberg situation
What is the sub dermal plexus?
terminal branches of cutaneous arteries found in hypodermis and subcutis ( sit below dermis
How to assess a wound ? for SA
-type of wound
degree tissue damage
depth
vital struc - bones , joints , tendons ,nerves
tip of the iceberg
-wound age
golden period = 6-8 hrs
contaminated or infected
-level of contamination
foreign material
dead tissue
bacterial innoculum ( bite vs clean glass)
take into account age and nature of wound
-lavage/debridement
gross contamination - tap water
flush hartmanns (35ml/60ml syringe ,18G needle = 7-8 psi )
no added antiseptics
debridement - dressings , surgical
-managment
primary intention
second intention healing
third intention
Define primary intention healing .
close straight away surgically
Define secondary healing
heal on its own via epithelialisation and contraction
Define third intention healing
delayed surgical closure
close over healthy granulation bed once debride