Drugs for skin disease

Question 1

Name drugs that moisturise/ improve skin barrier func with examples

Answer 1

-emollients - soften e.g coconut oil
-moisturiser - increase water content of the stratum corneum e.g aloe vera , glycerine
-improve skin barrier func - essential fatty acids

Question 2

Anti-seborrheic agent - what is it with examples

Answer 2

-control scale

-keratolytic - reduce cohesion between cells of stratum corneum
-keratoplastic - restore normal epithelialisation and keratinisation , reduce epithelial turn over

e.g sulphur , salicylic acid

Question 3

drugs to treat ear infection

Answer 3

topical corticosteroids and antimicrobials

Question 4

TRUE/FALSE ear infections are usually secondary to an underlying primary problem

Answer 4

true

Question 5

name ear cleaners and action

Answer 5

-cerumenolytics ( dissolve and soften cerumen ( ear wax ) ) - propylene glycol
-antimicrobials - chlorhexidine
-surfactants - sodium decusate
-astringents - alcohols

Question 6

Antibiotics for bites and trauma wounds SA

Answer 6

if systemically unwell
-cefuroxime and or cefalexin
-amoxicillin/clavulanate

Question 7

Treatment for surface pyoderma e.g intertrigo SA

Answer 7

-topical - chlorohexidine

if doesn’t respond …
-fusidic acid and or glucocoticoid
-silver sulphadiazine

Question 8

Treatment for superficial pyoderma SA

Answer 8

-topical - chlorohexidine

if not response
-clindamycin
-trimethoprim
-cefalexin
-amoxicillin/clavulanate

Question 9

Treatment for deep pyoderma SA

Answer 9

-sytemic if painful or risk of septicaemia whilst waiting for C and S
-topical - chlorohexidine

Question 10

treatment otitis externa SA

Answer 10

topical

-cocci - antiseptic ear cleaner and topical and or sytemic steroid
( no response ) - fusidic acid/framycetin

-rods - antiseptic ear cleaner whilst waiting reuslt , gentamicin , framycetin

Question 11

Topical antibiotics for a horse with superficial pyoderma

Answer 11

topical -antibacterial - chlorhexidine , silver sulphadiazine

Question 12

Systemic antibiotics for horse deep pyoderma

Answer 12

trimethoprim and sulphadiazine
doxycycline

Question 13

treatment for superficial infection in cattle of large area

Answer 13

-penicillin , cephalosporins —- low risk

Question 14

how treat abscesses in all animals except rabbit

Answer 14

-avoid antibiotics
-when mature - lance drain , flush and give NSAIDs if needed
-if pyrexic antibiotics

Question 15

How to treat abcesses in rabbit ?

Answer 15

-can’t lance
-antibiotics unlikely curative need to use with surgical management

Question 16

Topical antifungals

Answer 16

-miconazole - pyoderma , dermatophytosis
-enilconazole

Question 17

Systemic antifungals

Answer 17

-itraconazole -cats
-ketoconazole -dogs

Question 18

Drugs used in atopic dermatitis to control inflammation and pruritis

Answer 18

-gluccocorticoids - prednisolone
-oclacitinib ( anti-pruritic )
-lokivetmab ( anti - pruritic )
-ciclosporin ( anti-inflammatory )

Question 19

ASIT

Answer 19

Allergen-specific immunotherapy

• small amounts of relevant allergen to induce tolerance

Question 20

What else can you use to treat atopic dermatitis ? other than to control inflammation , pruritis or the allergen

Answer 20

-topical moisturisers
-control factors that might cause flare ups - antimicrobial shampoo

Question 21

Drugs used for autoimmune disease control

Answer 21

• gluccocorticoids at immunosuppressive levels e.g prednisolone and in horses dexamethasone or prednisolone
  -use others to help reach smaller dose with minimal side effects – e.g azathioprine ( NO cats ) , chlorambucil

*need to monitor - lesion control and side effects