antivirals and antifungals

Question 1

How do antivirals work ?

Answer 1

-stop replication of the virus in the cell
-block the ability for the virus to attach or enter host cells
-immune enhancement

Question 2

What antivirals could be used to treat Feline herpes virus FHV-1?

Answer 2

-topical with trifluridine -nucleoside analogue
-systemic with famciclovir - nucelotide analogue

Question 3

What antivirals would you give for FCV?

Answer 3

systemic
ribavirin toxic to cats
-feline interferon - immunomodulator /antiviral activity

Question 4

What antiviral would you give for feline chronic gingivostomatitis ?

Answer 4

systemic
feline interferon gamma - immunomodulator/ antiviral activity

Question 5

What antiviral would you use for canine parvovirus ?

Answer 5

-feline interferon gamma - immunomodulatory /antiviral activity

Question 6

What antiviral would you use for bird herpes virus ?

Answer 6

-aciclovir - nucleoside analogue

Question 7

Briefly describe Azoles with examples .

Answer 7

group of antifungals that inhibit ergosterol synthesis in fungal cells ( which is cytochrome P450 dependant )
e.g itraconazole

Question 8

Briefly describe Allylamines with examples .

Answer 8

group of antifungals that inhibit synthesis of ergosterol by inhibiting an enzyme
e.g terbinafine

Question 9

Briefly describe polyenes with examples .

Answer 9

group of antifungals that bind to sterols ( ergosterol) in fungal cell membrane.
e.g amphotericin B

Question 10

Briefly describe pyrimidine analogues with examples.

Answer 10

for example 5 fluorocytosine inhibits DNA and RNA synthesis in the fungal cell

Question 11

Give an example of cellular toxins - antifungal

Answer 11

silver sulfadiazine

Question 12

What antifungal should you not use in cats ?

Answer 12

terbinafine