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Pathopharmacology I > Wk 2 Carbapenems > Flashcards

Wk 2 Carbapenems Flashcards

1
Q

What is unique about carbapenems?

A

They are the broadest spectrum class of all antibiotics

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2
Q

What is the MOA of carbapenems?

A

Inhibit the cell wall and are bactericidal

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3
Q

When are carbapenems used?

A

Typically last resort antibiotics

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4
Q

What is the most concerning adverse effect of carbapanem drugs?

A

drug-induced seizure (not very common)

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5
Q

How are ALL carbapenems administered?

A

IV and over 60 minutes

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6
Q

What patient might carbapenems be contraindicated for?

A

Patients with epilepsy

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7
Q

What are the two carbapenems?

A

Imipenem/cilastin

Meropenem

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8
Q

Imipenem/cilastin can penetrate the…

A

blood brain barrier and meninges

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9
Q

What is important to watch for concerning imipenem/cilastin?

A

Seizures, especially in the elderly or those on other meds that may cause seizures

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10
Q

Imipenem/cilastin is very resistant to __ __

A

beta lactamase

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11
Q

Imipenem/cilastin is used for __ infections

A

complicated

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12
Q

Meropenem has a little less coverage than…

A

imipenem/cilastin

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13
Q

Meropenem is still very broad spectrum and works on what types of organisms?

A

gram-negative, gram-positive, and anaerobes

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14
Q

Meropenem doesn’t degrade in the __

A

kidneys

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15
Q

Meropenem has less __ activity than imipenem/cilastin

A

seizure

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16
Q

What are the two most common side effects of meropenem?

A

rash and diarrhea

17
Q

What carbapenem drug has less spectrum, but you only have to give once per day?

A

ertapenem

18
Q

What carbapenem is the newest and has even less seizure activity?

A

doripenem

19
Q

Doripenem is not for the treatment of __

A

pneumonia

20
Q

What type of bacteria is a growing public health concern?

A

Carbapenem-resistant enterobacteriaceae (CRE)

21
Q

What is the mortality rate of those who acquire CRE?

A

50% in some studies

Pathopharmacology I (33 decks)

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