Wk 2 Carbapenems Flashcards
What is unique about carbapenems?
They are the broadest spectrum class of all antibiotics
What is the MOA of carbapenems?
Inhibit the cell wall and are bactericidal
When are carbapenems used?
Typically last resort antibiotics
What is the most concerning adverse effect of carbapanem drugs?
drug-induced seizure (not very common)
How are ALL carbapenems administered?
IV and over 60 minutes
What patient might carbapenems be contraindicated for?
Patients with epilepsy
What are the two carbapenems?
Imipenem/cilastin
Meropenem
Imipenem/cilastin can penetrate the…
blood brain barrier and meninges
What is important to watch for concerning imipenem/cilastin?
Seizures, especially in the elderly or those on other meds that may cause seizures
Imipenem/cilastin is very resistant to __ __
beta lactamase
Imipenem/cilastin is used for __ infections
complicated
Meropenem has a little less coverage than…
imipenem/cilastin
Meropenem is still very broad spectrum and works on what types of organisms?
gram-negative, gram-positive, and anaerobes
Meropenem doesn’t degrade in the __
kidneys
Meropenem has less __ activity than imipenem/cilastin
seizure
What are the two most common side effects of meropenem?
rash and diarrhea
What carbapenem drug has less spectrum, but you only have to give once per day?
ertapenem
What carbapenem is the newest and has even less seizure activity?
doripenem
Doripenem is not for the treatment of __
pneumonia
What type of bacteria is a growing public health concern?
Carbapenem-resistant enterobacteriaceae (CRE)
What is the mortality rate of those who acquire CRE?
50% in some studies
