wk 14, lec 1 Flashcards
non STI infections
epididymtitis
orchitis
balanitis
chylamydia cause and sx
chylamydia trachmoatis
often symptomatic
urethritis- urethra discharge, dysuria
epipydymitis- scrotal pain and swell
rectal infection
gonorrhea cause and sx
neisseria gonorrhoea
urethritis; dysuria and discharge
epipdidymitis
chancroid cause and sx
haemophilus ducreyi
genital ulcers (chancroids)
inguinal lymphadenopathy
systemic sx: fever, malaise
condyloma latum
cause and sx
secondary syphilis (treponema pallidum)
genital lesions that are highly infections
systemic; fever, malaise, lymphadenopathy
human papilloma virus (HPV)
genital warts (condyloma acuminatum) from low risk HPV
Cervical Abnormalities, Other Anogenital Cancers.
Oropharyngeal lesions
high risk cause cancer
vaccine!
syphlis cause and stages
treponema pallidum
primary syphilis: painless ulcers (chancers)
secondary: chancre heals and then get rash and lesions and lymphadenopathy
latent: asymptomatic
tertiary: (if untreated) destructive lesions in many organs, CV, CNS, skin…
trichomoniasis cause and sx
trichomonas vaginalis
urethritis, prostatic, epipdicymtiis, dysuria, pruritis
Lymphogranuloma Venereum (LGV)
cause and sx and stages
chlamydia trachomatis serotypes L1-3
invade lymph –> systemic spread
primary: ulcer (chancre) at site
secondary: inguinal or femoral adenopathy, fever and malaise
tertiary: fibrosis and scarring of lymphs, genital elephantiasis
Herpes Simplex Virus (HSV)
primary infection: oral or genital ulcer, fever, maliase
recurrent: vesicles and ulcers
then have latent phase in between; lifelong infection latent in sensory ganglia (trigeminal or sacral)
epipdidymitis
from bacterial infection mostly coming from urethra or bladder
edema, infalmmed,
acute: unilateral scrotal pain, fever, dysuria, positive prehns sign (pain relief with scrotal elevation)
chronic: scrotal pain, swelling, sx wax and wain, fertility impacted
preens signs (relief of scrotal pain) in epipdydmitis vs orchitis
epidydmtis: postive
orchitis: negative
orchitis
inflamed one or both testicals usually from bacterial or viral infection (common to be secondary to epididymitis)
acute: unilateral or bilateral testicle pain, erythema, pain radiation to back or ab, fever, malaise, neagtive prehn’s sign
chronic: testicular pain and enlargement for months
balanitis
inflamed glans penis ; infectious or non infectious (i.e. poor hygiene, uncircumcised, allergy)
itch, burn, dysuria, pain during sex, white cheesy (smegma) under foreskin, ulcers, vesicles –> chronic could be scarring or phimosis (tighten foreskin)
congenital vs non congenital hypogonadism tx
Congenital cases may require both LH and FSH (for spermatogenesis) while
acquired cases post-puberty respond to LH alone
primary hypogonadism characteritiscs
low T and high gonadotropins (LH and FSH)
congenital or acquired
congenital: klinefelter sx, androgen insensitivity, autoimmune etc.
acquired: radiation, chemo, orchitis, meds
secondary hypogonadism
congenital hypogonadotrophic hypogonadism, kallmann syndrome
acquired: more common; meds (steroids, opioids), hyperprolactinemia, hypothalamus/ pituitary tumors
hypogoand sx
ED, low sperm, infertile, less muscle more fat, decrease hair, low BMD, depressed, cognitive decline, metabolism (T2D, dyslipidemia), CV (heart fail, stroke)
andropause/ late onset hypogonad
age related testosterone decline
Lower Urinary
Tract Symptoms (LUTS) contributing factors
Bladder dysfunction (overactive bladder)
Bladder outlet obstruction (i.e. benign prostatic hyperplasia)
Neurogenic causes (i.e. SCI, MS)
common cause of LUTS in men
BPH is a common cause of LUTS, leading to
urinary flow obstruction due to prostate enlargement
LUTS sx
Storage Symptoms: urgency, frequency, nocturia (increased urination at night), and urgency incontinence (leakage associated with urgency)
Voiding Symptoms: weak urinary stream, hesitancy (difficulty initiating urination), intermittency (stopping and
starting during urination), and incomplete emptying of
bladder
Postmicturition Symptoms: Post-void dribbling and the sensation of incomplete emptying
Benign Prostatic Hyperplasia (BPH)
enlargement of transition zone in prostate gland
hormonal changes
overgrowth of prostatic epithelial
and stromal cells, leading to formation of
nodules –> mechanical obstruction of urethra)
hormonal influence of BPH
testosterone –> DHT via 5-alpha reductase
stimulates prostate growth
aging can increase DHT levels and make prostate sensitive to androgens –> BPH