KEY NOTES WK 3 Flashcards
atopic dermatitis comorbid with
allergic asthma and allergic rhinitis
sx of atopic dermatitis
pruritis (itch), eczematous dermatiits
facial and extensors in infants
flexural in older
Ig_ and atopic dermatitis
IgE
pathogensis of atopic dermatitis
skin barrier defects- filagrin genes
altered immune, cytokines, t cells
xerosis
filaggrin defieicny sx in atopic dermatitis
ichthyosis vulgaris, keratosis pilaris, and hyperlinear palms.
increases transepidermal water loss
Th_ in atopic dermatitis and Ig_
Th2, IgE, eosinophilia
also Th1
exogenous things that can worse atopic dermatitis
scratching, proteases from dust mites, staph aureus
genes in atopic dermatitis and what complex is it involved in
Filaggrin gene is found on chromosome 1q21 (minority of patents have FLG null mutation, its usually immune mediated reduction in epidermal differentiation)
which is involved in epidermal differentiation complex
acute vs chronic lesions of atopic dermatitis
acute: epidermal spongiosis (edema), T cell with CLA, mast cells, dendritic APCs (langerhans)
chronic: lichenified, hyperkeratosis, minimal spongiosis, more IgE langerhans, macrophages, fully granulated mast cells
what immune cell is absent in atopic dermatitis
neutrophils
2 key cytokines causing atopic dermatitis inflammation and causing a Th_
TSLP and IL-33 (Th2)
also IL22 IL17 IL4 and Il13
also Th1 cytokines INFy
IL5 for eosinophils
Chemokines: CTACK, CCR4, CCL17,
FUCK ETC…..
severity of atopic dermatitis correlates with
evels of thymus and activation-regulated cytokine (TARC)
which cytokines down regulate filaggrin expression in atopic dermatitis
TSLp, IL4, IL13
pruritis in atopic dermatitis because
allergen induced release of histamine
T cell cytokines: IL-31, stress induced neuropeptides (substance P and CGRP), proteases , eicosanoids (from arachidonic acid), eosinophil-derived proteins (major basic protein and eosinophil derived neurotoxin)
hypersensitivity rxn in allergic contact dermatitis
type IV (delayed)
steps of allergic contact dermatitis
sensitization (hapten binds skin and forms complex)
need subsequent exposure to get inflammatory response
gold standard test for allergic contact dermatitis
patch testing
examples of allergic contact dermatiis
nickle, cosmetics, gragnace, textiles, rubber gloves, glue
allergic contact dermatitis sx
pruritic, eczematous, edema, erythema, vesicle or papule then can be lichenification and scaling if chronic
geometric, linear or focal pattern
2 phases of allergic contact dermaitis
- sensitization phase: initial contact with allergen to develop immunologic memory, need sufficient exposure of sensitizing chemical
- elicitation phase; re-exposure triggers inflammatory rxn to minute quantities of allergen
how do haptens play a role in allergic contact dermatitis
hapten protein complex forms = antigen –> trigger immune response
keratinocytes release GM-CSF, TNFa, IL1, IL8, IL18 upon hapten exposure
langerhan and dendritic cells uptake antigen and express on HLA for T cells which get skin homing antigens
T cells become memory so then next exposure will react
elicitation phase of allergic contact dermatitis
Inducible Skin-Associated Lymphoid Tissue (iSALT)
effect T cell recruitment (APCs on langerhans and dermal dendritic cells)
irritant dermatitis differs from allergic contact dermatitis
ACD need complete avoidance
ACD need sensitization phase
irritant predisposes to ACD
treat irritant dermatitis
emollients
hardening= disappearance of sx